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Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.

Published in Biotechnology advances

In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marrow or peripheral blood. More recently, RBCs have b...

Delineating stages of erythropoiesis using imaging flow cytometry.

Published in Methods (San Diego, Calif.)

Adult humans need to make 2.5million red blood cells (RBCs) every second to maintain a steady state level of 25trillion circulating RBCs. Understanding normal erythropoiesis as well as diseases that afflict the erythron, such as genetic anemias, hyperproliferative disorders, and myelodysplastic syndromes, requires a robust method to delineate eryth...

Hフェリチンはトランスフェリン受容体1を介して閾値依存性にヒト赤芽球系細胞に優先的に取り込まれる

学位規則第4条第1項該当

Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective.

Published in Current topics in developmental biology

Complex developmental programs require orchestration of intrinsic and extrinsic signals to control cell proliferation, differentiation, and survival. Master regulatory transcription factors are vital components of the machinery that transduce these stimuli into cellular responses. This is exemplified by the GATA family of transcription factors that...

Hemangioblastic foci in human first trimester placenta: Distribution and gestational profile.

INTRODUCTION: The human placenta is a site of both hematopoiesis and vasculogenesis. There are reports of hemangioblastic foci (HAF) in the first trimester placenta, but little published information about their spatiotemporal incidence. METHODS: We have used semi-thin sections and whole mount staining techniques on archival early pregnancy hysterec...

Hemangioblastic foci in human first trimester placenta: Distribution and gestational profile.

INTRODUCTION: The human placenta is a site of both hematopoiesis and vasculogenesis. There are reports of hemangioblastic foci (HAF) in the first trimester placenta, but little published information about their spatiotemporal incidence. METHODS: We have used semi-thin sections and whole mount staining techniques on archival early pregnancy hysterec...

Hemangioblastic foci in human first trimester placenta: Distribution and gestational profile.

Published in Placenta

The human placenta is a site of both hematopoiesis and vasculogenesis. There are reports of hemangioblastic foci (HAF) in the first trimester placenta, but little published information about their spatiotemporal incidence. We have used semi-thin sections and whole mount staining techniques on archival early pregnancy hysterectomy material as well a...

The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling.

Published in Journal of cell science

Megakaryocyte and erythroid development are tightly controlled by a repertoire of cytokines, but it is not clear how cytokine-activated signaling pathways are controlled during development of these two lineages. Here, we identify that expression of DLX4, a transcription factor encoded by a homeobox gene, increases during megakaryopoiesis but decrea...