Schindele, Alexandra Holm, Anna Kraft, Sofie Nylander, Karin Allard, Annika Olofsson, Katarina
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease in which inflammatory responses to exogenic stressors, such as viral infections, has been recognised. The role of viruses in CRSwNP pathogenesis is unclear. Aims/objectives: We aimed to characterise Epstein-Barr virus (EBV), human papillomavirus (HPV), human cytomegal...
Faraidun, Hemin Tassery, Herve Tardivo, Delphine Lan, Romain
Periodontitis is the inflammation of the supporting structures around the dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On the other hand, oral cavity is a rich reservoir for viruses since it contains a wide variety of cell types that can be targeted by viruses. Traditionall...
Published in
Frontiers in Oncology
Introduction Epstein-Barr virus (EBV) infection has been linked to cervical cancer (CC), but few have described the clinical and outcome features of patients with CC and EBV infection. Methods We conducted a single-center matched cohort study on 94 patients with CC. Real-time Polymerase chain reaction (RT-PCR) was used to detect EBNA-1 (Epstein-Bar...
Satoskar, Monika A. Lordo, Matthew R. Jones, Daniel M. Nowacki, Nicholas B. Brammer, Jonathan E. Reneau, John C. Voorhees, Timothy J.
Published in
Frontiers in Hematology
Introduction Diffuse large B-cell lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma that accounts for approximately a quarter of all lymphomas in the United States. It is rare to have co-occurring T cell lymphoma with DLBCL as they often develop following treatment of DLBCL rather than concomitantly. Case presentation We report a 71-ye...
Wang, Yaohao Yu, Jingwen Pei, Yonggang
Published in
Frontiers in Microbiology
Epstein-Barr virus (EBV) infects more than 90% of the human population worldwide and establishes lifelong infection in hosts by switching between latent and lytic infection. EBV latency can be reactivated under appropriate conditions, leading to expression of the viral lytic genes and production of infectious progeny viruses. EBV reactivation invol...
Yan, Sijia Ming, Xi Zhu, Xiaojian Xiao, Yi
Published in
Frontiers in Immunology
Chronic active Epstein-Barr Virus disease is a kind of Epstein-Barr Virus associated T/NK cell lymphoproliferative disease. At present, there is still a lack of standard therapeutic regimen for its treatment, but its basic treatment principles include controlling inflammatory response, anti-tumor proliferation, and immune reconstitution. Hematopoie...
Ovchinnikova, Leyla A. Eliseev, Igor E. Dzhelad, Samir S. Simaniv, Taras O. Klimina, Ksenia M. Ivanova, Maria Ilina, Elena N. Zakharova, Maria N. Illarioshkin, Sergey N. Rubtsov, Yury P.
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Published in
Frontiers in Immunology
Background Multiple sclerosis (MS) is a neuroinflammatory disease triggered by a combination of genetic traits and external factors. Autoimmune nature of MS is proven by the identification of pathogenic T cells, but the role of autoantibody-producing B cells is less clear. A comprehensive understanding of the development of neuroinflammation and th...
Ishiguro, Kenji Ishikawa, Kazuhiro Matsuo, Takahiro Mori, Nobuyoshi
Published in
Internal medicine (Tokyo, Japan)
Sialadenitis has rarely been reported in patients with infectious mononucleosis (IM). Our patient was a 22-year-old man who presented with bilateral swelling of the parotid and submandibular glands, a fever, malaise, and splenomegaly. Laboratory tests revealed an increased percentage of atypical lymphocytes in the leukocyte fraction. Serological te...
Li, Yuyu Sun, Mingming Wei, Shihui Xu, Quangang Zhou, Huanfen
Published in
Frontiers in Immunology
Background Bilateral optic neuritis associated with optic disc swelling is a common feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, extensive deep retinal haemorrhages have not been described in the context of MOG-associated optic neuritis. Here, we report a case of infectious mononucleosis with marked b...
Zhen, James Chen, Jia Huang, Haigen Liao, Shiqing Liu, Shiheng Yuan, Yan Sun, Ren Longnecker, Richard Wu, Ting-Ting Zhou, Z. Hong
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Published in
Journal of Virology
Discovered in 1964, Epstein-Barr virus (EBV) is the first identified human oncogenic virus and the founding member of the gammaherpesvirus subfamily. In 1994, another cancer-causing virus was discovered in lesions of AIDS patients and later named Kaposi’s sarcoma-associated herpesvirus (KSHV), the second human gammaherpesvirus. Despite the historic...
