Štiavnická, Miriama Chaulot-Talmon, Aurélie Perrier, Jean-Philippe Hošek, Petr Kenny, David A. Lonergan, Patrick Kiefer, Hélène Fair, Sean
Published in
BMC Genomics
Background Despite a multifactorial approach being taken for the evaluation of bull semen quality in many animal breeding centres worldwide, reliable prediction of bull fertility is still a challenge. Recently, attention has turned to molecular mechanisms, which could uncover potential biomarkers of fertility. One of these mechanisms is DNA methyla...
Uddin, Md Sahab Mamun, Abdullah Al Alghamdi, Badrah S Tewari, Devesh Jeandet, Philippe Sarwar, Md Shahid Ashraf, Ghulam Md
Published in
Seminars in cancer biology
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be mild and slowly aggravated, although other symptoms might demonstrate it as an acute ailment. However, the precise mechanisms of the development of GBM remain unknown. Due to the ...
Ahmad, Shama Manzoor, Shajer Siddiqui, Simmone Mariappan, Nithya Zafar, Iram Ahmad, Aamir Ahmad, Aftab
Published in
Seminars in cancer biology
Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associated mortality that has affected millions of individuals worldwide. Inflammation and pulmonary manifes...
Burton, Nicholas O Greer, Eric L
Published in
Seminars in cell & developmental biology
Inherited epigenetic information has been observed to regulate a variety of complex organismal phenotypes across diverse taxa of life. This continually expanding body of literature suggests that epigenetic inheritance plays a significant, and potentially fundamental, role in inheritance. Despite the important role these types of effects play in bio...
Sukocheva, Olga A Lukina, Elena Friedemann, Markus Menschikowski, Mario Hagelgans, Albert Aliev, Gjumrakch
Published in
Seminars in cancer biology
Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regulation patterns. During TAM/SERM...
Nema, Juhi Joshi, Nikita Sundrani, Deepali Joshi, Sadhana
Published in
Placenta
Studies have shown that the maternal nutrition during critical periods of development not only influences fetal growth but also plays a significant role in determining the risk of chronic disease in later life through developmental 'programming'. The placenta acts as a tool for 'programming' as it has the ability to adapt according to the maternal ...
Özdemir, Isa Steiner, Florian A
Published in
Seminars in cell & developmental biology
Epigenetic inheritance refers to the transmission of phenotypes across generations without affecting the genomic DNA sequence. Even though it has been documented in many species in fungi, animals and plants, the mechanisms underlying epigenetic inheritance are not fully uncovered. Epialleles, the heritable units of epigenetic information, can take ...
Lauko, Adam Lo, Alice Ahluwalia, Manmeet S Lathia, Justin D
Published in
Seminars in cancer biology
Brain tumors remain one of the most difficult tumors to treat and, depending on the diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common malignant glioma and has a dismal prognosis, with only about 5% of patients alive five years after diagnosis. While advances in targeted therapies and immunotherapies are rapidl...
Bartlett, Thomas E. Evans, Iona Jones, Allison Barrett, James E. Haran, Shaun Reisel, Daniel Papaikonomou, Kiriaki Jones, Louise Herzog, Chiara Pashayan, Nora
...
Published in
Genome Medicine
Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. We suggest that targeting progesterone signalling could be a...
Turkmendag, Ilke Liaw, Ying-Qi
Published in
Medicine, Health Care, and Philosophy
This paper examines the construction of maternal responsibility in transgenerational epigenetics and its implications for pregnant women. Transgenerational epigenetics is suggesting a link between maternal behaviour and lifestyle during pregnancy and the subsequent well-being of their children. For example, poor prenatal diet and exposure to matern...
