Single-cell analysis enters the multiomics age
Published in Nature
A rapidly growing collection of software tools is helping researchers to analyse multiple huge ‘-omics’ data sets.
Hi–C interaction graph analysis reveals the impact of histone modifications in chromatin shape
Published in Applied Network Science
Chromosome conformation capture experiments such as Hi–C map the three-dimensional spatial organization of genomes in a genome-wide scale. Even though Hi–C interactions are not biased towards any of the histone modifications, previous analysis has revealed denser interactions around many histone modifications. Nevertheless, simultaneous effects of ...
ARPEGGIO: Automated Reproducible Polyploid EpiGenetic GuIdance workflOw
Published in BMC Genomics
BackgroundWhole genome duplication (WGD) events are common in the evolutionary history of many living organisms. For decades, researchers have been trying to understand the genetic and epigenetic impact of WGD and its underlying molecular mechanisms. Particular attention was given to allopolyploid study systems, species resulting from an hybridizat...
Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers
Published in Current Oncology Reports
Purpose of ReviewBiological age is the concept of using biophysiological measures to more accurately determine an individual’s age-related risk of adverse outcomes. Grading of the degree of frailty and measuring biomarkers are distinct methods of measuring biological age. This review compares these strategies for estimating biological age for clini...
Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes
...Published in Environmental Health
BackgroundArsenic (As) exposure through drinking water is a global public health concern. Epigenetic dysregulation including changes in DNA methylation (DNAm), may be involved in arsenic toxicity. Epigenome-wide association studies (EWAS) of arsenic exposure have been restricted to single populations and comparison across EWAS has been limited by m...
5-aza-2′-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human ut...
Published in Reproductive Biology and Endocrinology
BackgroundUterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-aza-CdR), have been suggested to treat tumors in which DNA methylation is altered. We aimed to evaluate whether DNA methylation rev...
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Published in Clinical Epigenetics
Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4 (H3K4me3) located after first exons and around transcription start sites. This epigenetic mark is typically restricted to narrow regions at the 5`end of the gene body, though a small subset of genes have a broad H3K4me3 domain which extensively covers the codi...
Assessment and pathophysiology of microvascular disease: recent progress and clinical implications.
...Published in European heart journal
The development of novel, non-invasive techniques and standardization of protocols to assess microvascular dysfunction have elucidated the key role of microvascular changes in the evolution of cardiovascular (CV) damage, and their capacity to predict an increased risk of adverse events. These technical advances parallel with the development of nove...
Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits & ndash; A systematic ...
status: published
Diagnosis and treatment of lymphomas in the era of epigenetics.
Published in Blood reviews
Lymphomas represent a heterogeneous group of cancers characterized by clonal lymphoproliferation. Over the past decades, frequent epigenetic dysregulations have been identified in hematologic malignancies including lymphomas. Many of these impairments occur in genes with established roles and well-known functions in the regulation and maintenance o...
