Ihezie, Stephanie A. Mathew, Iny Elizebeth McBride, Devin W. Dienel, Ari Blackburn, Spiros L. Thankamani Pandit, Peeyush Kumar
Published in
Fluids and Barriers of the CNS
The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transporters, and limited endocytosis which combine to protect the brain from toxins and maintains brain homeostasis. Blood–brain barrier (BBB) leak...
Post, Robert M. Altshuler, Lori L. Kupka, Ralph McElroy, Susan L. Frye, Mark A. Grunze, Heinz Suppes, Trisha Keck, Paul E. Jr Nolen, Willem A.
Published in
International Journal of Bipolar Disorders
BackgroundThe Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as Europe). When funding was discontinued, the international group of investigators continued to work together as the Bipolar Collabo...
Hua, S Gu, M Wang, Y Ban, D Ji, H
Published in
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Colorectal cancer (CRC) represents an important neoplasm with high mortality. Although PD-L1/PD-1 system-based immunotherapy has benefits for a certain type of CRC, many efforts should be made to enhance the responses to anti-PD-1/PD-L1 drugs. DNA methylation has been critically implicated in the regulation of tumor immunity. Here, we examined the ...
Zhou, Shumin Feng, Shenglei Qin, Weibing Wang, Xiaoli Tang, Yunge Yuan, Shuiqiao
Published in
Stem cell reviews and reports
Spermatogonial stem cells(SSCs)are the ultimate germline stem cells with the potential of self-renewal and differentiation, and a dynamic balance of SSCs play an essential role in spermatogenesis. During the gene expression process, genomic DNA and nuclear protein, working together, contribute to SSC homeostasis. Recently, emerging studies have sho...
Wang, Weijing Li, Weilong Jiang, Wenjie Lin, Haijun Wu, Yili Wen, Yanhua Xu, Chunsheng Tian, Xiaocao Li, Shuxia Tan, Qihua
...
Published in
Journal of psychiatric research
Cognitive ability plays an important role in mental and physical well-beings in the increasingly ageing populations. Here, based on a sample of 30 cognitive function-discordant monozygotic twin pairs, we aimed to detect specific epigenetic variants potentially related to cognitive function by conducting an epigenome-wide association study (EWAS). A...
Connacher, Jessica Josling, Gabrielle A. Orchard, Lindsey M. Reader, Janette Llinás, Manuel Birkholtz, Lyn-Marié
Published in
Epigenetics & Chromatin
BackgroundThe Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological changes from commitment to maturity, directed by an equally extensive control program. However, the processes tha...
Sarno, Federica Benincasa, Giuditta List, Markus Barabasi, Albert-Lazlo Baumbach, Jan Ciardiello, Fortunato Filetti, Sebastiano Glass, Kimberly Loscalzo, Joseph Marchese, Cinzia
...
Published in
Clinical Epigenetics
Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach re...
Lodewijk, Iris Nunes, Sandra P. Henrique, Rui Jerónimo, Carmen Dueñas, Marta Paramio, Jesús M.
Published in
Clinical Epigenetics
BackgroundEpigenetic alterations are known contributors to cancer development and aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks are present in cells of the tumor microenvironment, including lymphocytes and tumor-associated macrophages, which are often overlooked but known to be a contributing factor to a favor...
Seddon, Annika R. Liau, Yusmiati Pace, Paul E. Miller, Allison L. Das, Andrew B. Kennedy, Martin A. Hampton, Mark B. Stevens, Aaron J.
Published in
Epigenetics & Chromatin
BackgroundEnvironmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by sublethal doses of hydrogen peroxide (H2O2). However, site-specific changes in DNA methylation and the reversibility of any changes have no...
Han, Jinming Fan, Yueshan Zhou, Kai Blomgren, Klas Harris, Robert A.
Published in
Journal of Neuroinflammation
There are inherent structural and functional differences in the central nervous systems (CNS) of females and males. It has been gradually established that these sex-specific differences are due to a spectrum of genetic, epigenetic, and hormonal factors which actively contribute to the differential incidences, disease courses, and even outcomes of C...