In the context of climate change plants have to cope with adverse conditions, among whichwater scarcity is a major threat for their survival. Thus, the regulatory processes of plants toface drought may differ depending on their ecological preferences. The European white oakcomplex is mainly formed by two species, Pedunculate (PO) and Sessile oak (S...
Published in Journal of biomolecular structure & dynamics
The identification of potential epigenetic targets for a known bioactive compound is essential and promising as more and more epigenetic drugs are used in cancer clinical treatment and the availability of chemogenomic data related to epigenetics increases. In this study, we introduce a novel epigenetic target identification strategy (ETI-Strategy) ...
Objectif : l’étiologie des MIH n’étant pas entièrement élucidée et les études scientifiques récemment publiées avançant de plus en plus que les facteurs génétiques et/ou épigénétiques sont en lien avec cette maladie, l’objectif de cette étude est de déterminer l’association existant entre ces facteurs et la MIH. Matériel et méthode : il s’agit d’un...
Abstract Background In plants, epigenetic stress memory has so far been found to be largely transient. Here, we wanted to assess the heritability of heat stress-induced epigenetic and transcriptomic changes following woodland strawberry ( Fragaria vesca ) reproduction. Strawberry is an ideal model to study epigenetic inheritance because it presents...
Agroecological transitions of the current agrifood systems unfold against a backdrop of mounting pressure from climate change (encompassing heatwaves, droughts, emergence of new pathogens, …). To improve the sustainability of our agricultural systems in the context of climate change, it is essential to understand how individuals can adapt to enviro...
This thesis explores the use of biological clocks, studied at the molecular level, inunderstanding and predicting animal traits that change over time. In particular, thethesis focuses on two biological clocks: the circadian clock and the epigenetic clock.The study aimed to shed light on how these clocks, along with specific genesassociated with the...
Published in Journal of molecular neuroscience : MN
Protein acetylation, which is dynamically maintained by histone acetyltransferases (HATs) and deacetylases (HDACs), might play essential roles in hippocampal exercise physiology. However, whether HATs/HDACs are imbalanced during the recovery phase following acute exercise has not been determined. Groups of exercised mice with different recovery per...
Published in Environmental research
Human beings are routinely exposed to chronic and low dose of Bisphenols (BPs) due to their widely pervasiveness in the environment. BPs hold similar chemical structures to 17β-estradiol (E2) and thyroid hormone, thus posing threats to human health by rendering the endocrine system dysfunctional. Among BPs, Bisphenol-A (BPA) is the best-known and e...
Le métabolisme énergétique et l'épigénétique sont hautement interconnectés, le métabolisme fournissant les composés nécessaires pour les réactions épigénétiques, et ces modifications épigénétiques régulant à leur tour l'expression des gènes en fonction des besoins énergétiques de la cellule. Cette interaction est cruciale pour le fonctionnement nor...
Published in The Science of the total environment
Adaptation to environmental stressors is an essential property of plants that allows them, despite an immobile lifestyle, to survive in a changeable environment. The chain of successive events culminating in the final radiobiological reaction begins with the absorption of energy of ionizing radiation in the cell. Starting from stochastic acts of mo...
