Xu, Liyan Wang, Yan
Published in
Acta neurologica Belgica
Genetic variants of ABCB1 may affect intestinal absorption of aspirin (ASA). However, it is unclear whether ABCB1 polymorphisms and DNA methylation are associated with ASA efficacy for ischemic stroke. Our aims is to investigate the association between ABCB1 polymorphisms and methylation status on the antiplatelet effects of ASA in Chinese Han isch...
Zhang, Yang Xiao, Ying Li, Gui-Chen Gong, Feng-Yan Zhang, Xiao-Na Hou, Kun
Published in
Seminars in cancer biology
Gliomas are aggressive brain tumors with high mortality rate. Over the past several years, non-coding RNAs, specifically the long non-coding RNAs (lncRNAs), have emerged as biomarkers of considerable interest. Emerging data reveals distinct patterns of expressions of several lncRNAs in the glioma tissues, relative to their expression in normal brai...
Neganova, Margarita E Klochkov, Sergey G Aleksandrova, Yulia R Aliev, Gjumrakch
Published in
Seminars in cancer biology
Epigenetic changes associated with histone modifications play an important role in the emergence and maintenance of the phenotype of various cancer types. In contrast to direct mutations in the main DNA sequence, these changes are reversible, which makes the development of inhibitors of enzymes of post-translational histone modifications one of the...
Villagómez-Aranda, A L Feregrino-Pérez, A A García-Ortega, L F González-Chavira, M M Torres-Pacheco, I Guevara-González, R G
Published in
Plant cell reports
Plants are continuously exposed to stress conditions, such that they have developed sophisticated and elegant survival strategies, which are reflected in their phenotypic plasticity, priming capacity, and memory acquisition. Epigenetic mechanisms play a critical role in modulating gene expression and stress responses, allowing malleability, reversi...
Palomba, Maria Lia Cartron, Guillaume Popplewell, Leslie Ribrag, Vincent Westin, Jason Huw, Ling-Yuh Agarwal, Shefali Shivhare, Mahesh Hong, Wan-Jen Raval, Aparna
...
Published in
Clinical lymphoma, myeloma & leukemia
The combination of atezolizumab, a monoclonal antibody that targets programmed death-ligand 1 (PD-L1) and inhibits the interaction between PD-L1 and its receptors, and tazemetostat, an EZH2 inhibitor, may lead to selective epigenetic reprogramming, alter the tumor microenvironment, and provide additive or synergistic response to patients with relap...
Huang, Chia-Hung Chang, Man-Chen Lai, Yung-Chun Lin, Chun-Yen Hsu, Cho-Hsien Tseng, Bo-Yuan Hsiao, Chuhsing Kate Lu, Tzu-Pin Yu, Sung-Liang Hsieh, Sung-Tsang
...
Published in
Clinical Epigenetics
Background Despite the brain’s high demand for energy, research on its epigenetics focuses on nuclear methylation, and much of the mitochondrial DNA methylation remains seldom investigated. With a focus on the nucleus accumbens (NAcc) and the prefrontal cortex (PFC), we aimed to identify the mitochondrial methylation signatures for (1) distinguishi...
Fallet, Manon Montagnani, Caroline Petton, Bruno Dantan, Luc de Lorgeril, Julien Comarmond, Sébastien Chaparro, Cristian Toulza, Eve Boitard, Simon Escoubas, Jean-Michel
...
Published in
Microbiome
Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas , the role of the environmental microbial community on immune system maturation — and, importantly, protecti...
Schröder, Rieke Illert, Anna-Lena Erbes, Thalia Flotho, Christian Lübbert, Michael Duque-Afonso, Jesús
Published in
Epigenetics
The stage and molecular pathology-dependent prognosis of breast cancer, the limited treatment options for triple-negative carcinomas, as well as the development of resistance to therapies illustrate the need for improved early diagnosis and the development of new therapeutic approaches. Increasing data suggests that some answers to these challenges...
Khatami, Fatemeh Gorji, Alireza Khoshchehreh, Mahdi Mashhadi, Rahil Pishkuhi, Mahin Ahmadi Khajavi, Alireza Shabestari, Alireza Namazi Aghamir, Seyed Mohammad Kazem
Published in
BMC Medical Genomics
Objectives Recurrent Kidney stone formation is a main medical problem imposing a significant burden on both healthcare and the economy worldwide. Environmental and genetic factors have been linked to a bigger risk of kidney stone formation. We aim to assess the role of methylation on recurrent stone formation in three target genes. Methods We aimed...
Srivastava, Arpna Banerjee, Jyotirmoy Dubey, Vivek Tripathi, Manjari Chandra, P Sarat Sharma, M C Lalwani, Sanjeev Siraj, Fouzia Doddamani, Ramesh Dixit, Aparna Banerjee
...
Published in
Cellular and molecular neurobiology
Histone deacetylases (HDACs) have been described to have both neurotoxic and neuroprotective roles, and partly, depend on its sub-cellular distribution. HDAC inhibitors have a long history of use in the treatment of various neurological disorders including epilepsy. Key role of HDACs in GABAergic neurotransmission, synaptogenesis, synaptic plastici...
