Leducq, Valentin Jary, Aude Bridier-Nahmias, Antoine Daniel, Lena Zafilaza, Karen Damond, Florence Goldstein, Valérie Duval, Audrey Blanquart, François Calvez, Vincent
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Published in
Scientific reports
France went through three deadly epidemic waves due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing major public health and socioeconomic issues. We proposed to study the course of the pandemic along 2020 from the outlook of two major Parisian hospitals earliest involved in the fight against COVID-19. Genome sequencing ...
Kwan, Albert K. Piazza, Gary A. Keeton, Adam B. Leite, Caio A.
Published in
Journal of Experimental & Clinical Cancer Research
The RAS oncogene is both the most frequently mutated oncogene in human cancer and the first confirmed human oncogene to be discovered in 1982. After decades of research, in 2013, the Shokat lab achieved a seminal breakthrough by showing that the activated KRAS isozyme caused by the G12C mutation in the KRAS gene can be directly inhibited via a newl...
Garcia-Montoya, Leticia Nam, Jacqueline L. Duquenne, Laurence Villota-Eraso, Catalina Di Matteo, Andrea Hartley, Collette Mankia, Kulveer Emery, Paul
Published in
Arthritis Research & Therapy
BackgroundMusculoskeletal (MSK) symptoms are among the commonest reasons for primary care assessments; however, few individuals will be diagnosed with an inflammatory arthritis (IA) within the following year. The purpose of this study was to investigate, in individuals with new MSK symptoms, the association between patient factors and risk of progr...
Adam, David
Published in
Nature
Countries have reported some five million COVID-19 deaths in two years, but global excess deaths are estimated at double or even quadruple that figure. Credit: Andre Coelho/GettyRelatives of a deceased person mourn during a mass burial of COVID-19 victims at the Parque Taruma cemetery in Manaus, Brazil.
Sadecki, Emily Weaver, Amy Zhao, Yulian Stewart, Elizabeth A. Ainsworth, Alessandra J.
Published in
Reproductive Health
This study aimed to assemble a historic cohort of women with primary infertility and age-matched control women. The cohort included 1001 women with primary infertility diagnosed between 1980 and 1999 and 1001 age-matched controls from the same community and era. This cohort demonstrated baseline differences between the primary infertility and contr...
Park, Jimyung You, Seng Chan Cho, Jaehyeong Park, Chan Hyuk Shin, Woon Geon Park, Rae Woong In Seo, Seung
Published in
BMC Pharmacology and Toxicology
BackgroundThis study aimed to evaluate incidence risk and adverse clinical outcomes in COVID-19 disease among short-term users of acid-suppressants in South Korea.MethodsThis retrospective cohort study, conducted using a nationwide claims database for South Korea, used data from patients with COVID-19 tested between January 1 and May 15, 2020. Pati...
McCartney, Daniel L. Hillary, Robert F. Conole, Eleanor L. S. Banos, Daniel Trejo Gadd, Danni A. Walker, Rosie M. Nangle, Cliff Flaig, Robin Campbell, Archie Murray, Alison D.
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Published in
Genome Biology
BackgroundBlood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia.ResultsUsing blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of th...
Halili, Rrezart Bunjaku, Jeta Gashi, Bujar Hoxha, Teuta Kamberi, Agron Hoti, Nexhmedin Agahi, Riaz Basha, Vlora Berisha, Visar Hoxha, Ilir
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Published in
BMC Infectious Diseases
Primary healthcare workers have a prevalence of 17.47% for SARS-CoV-2 antibodies Almost half of those surveyed had either tested positive by PCR or had antibodiesWe did not find a significant association with adherence to protective measuresInfected family members significantly increased the odds of seropositivity
Goettler, David Niekler, Patricia Liese, Johannes G. Streng, Andrea
Published in
BMC Public Health
IntroductionDetailed and up-to-date data on the epidemiology and healthcare costs of Influenza are fundamental for public health decision-making. We analyzed inpatient data on Influenza-associated hospitalizations (IAH), selected complications and risk factors, and their related direct costs for Germany during ten consecutive years.MethodsWe conduc...
Visaria, Aayush Lo, David Maniar, Pranay Dave, Bhoomi Joshi, Parag
Published in
Clinical Hypertension
BackgroundWe sought to determine the association between appendicular adiposity and hypertension, with the purpose of better understanding the role of body fat distribution on blood pressure (BP).MethodsWe included 7411 adults aged 20 to 59 who were not taking antihypertensives and without cardiovascular disease from the 2011 to 2018 National Healt...
