Brown, Nolan J Wilson, Bayard Lien, Brian V Himstead, Alexander Tafreshi, Ali R Shahrestani, Shane Birkenbeuel, Jack Tran, Katelynn Horton, David Paladugu, Anushka
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Published in
Neurosurgical review
The history of academic research on ependymoma is expansive. This review summarizes its history with a bibliometric analysis of the 100 most cited articles on ependymoma. In March 2020, we queried the Web of Science database to identify the most cited articles on ependymoma using the terms "ependymoma" or "ependymal tumors," yielding 3145 publicati...
Jecko, Vincent Roblot, Paul Mongardi, Lorenzo Ollivier, Morgan Piccoli, Natalia Delgado Charleux, Thomas Wavasseur, Thomas Gimbert, Edouard Liguoro, Dominique Chotard, Guillaume
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Published in
Neurospine
Objective Spinal cord tumors constitute a small part of spinal surgery owing to their rarity. This retrospective study describes their current management. Methods Forty-eight patients were treated for an intramedullary tumor between 2014 and 2020 at a single institution. Patients’ files were retrospectively studied. We detailed clinical status acco...
Ishikawa, Kazuki Ishii, Masaki Yaguchi, Takashi Katada, Toshiaki Ichinose, Koji Ohata, Shinya
Published in
Biochemical and biophysical research communications
Nuclear factor-kappa B (NF-κB) signaling is an intracellular signaling pathway involved in inflammatory responses and the pathogenesis of various cancers, including ependymoma, which is a rare and chemotherapy-resistant glioma. Several isoforms of fusion proteins that consist of a nuclear protein, zinc finger translocation associated (ZFTA), and RE...
Batchu, Sai Patel, Karan Yu, Siyuan Mohamed, Aleem T Karsy, Michael
Published in
Gene
Ependymomas are biologically diverse tumors with five major genomic subgroups. However, intratumor heterogeneity continues to be poorly understood. The present study characterized the metabolic landscapes of ependymoma subgroups at the single-cell level. Expression profiles from 11,200 ependymoma single cells derived from the five major subgroups a...
Wheeler, Austin Metrock, Katie Li, Rong Singh, Sumit
Published in
Radiology Case Reports
We report a case of multifocal cystic meningioangiomatosis (MA), an exceptionally uncommon diagnosis even in patients with type 2 neurofibromatosis (NF2). A 2-year-old male with personal as well as family history of genetically-confirmed NF2 presented with incidental findings of MA after imaging for closed-head injury. Computed tomography and magne...
Grady, Clare Melnick, Kaitlyn Porche, Ken Dastmalchi, Farhad Hoh, Daniel J. Rahman, Maryam Ghiaseddin, Ashley
Published in
Neurospine
Spinal cord gliomas are rare entities that often have limited surgical options. Immunotherapy has shown promise in intracranial gliomas with some research suggesting benefit for spinal cord gliomas. A focused review of immunotherapies that have been investigated in spinal cord gliomas was performed. The primary methods of immunotherapy investigated...
Yeh, Karen W He, Di Hansen, Johnni Carpenter, Catherine L Ritz, Beate Olsen, Jorn Heck, Julia E
BackgroundHead trauma has been associated with increased brain tumor risk in adults. Instrument assisted delivery can be a cause of head trauma in newborns. The goal of this study was to determine if instrument-assisted deliveries influenced the odds of childhood brain tumors in Denmark.MethodsWe conducted a matched case-control study of childhood ...
Shatara, Margaret Schieffer, Kathleen M. Klawinski, Darren Thomas, Diana L. Pierson, Christopher R. Sribnick, Eric A. Jones, Jeremy Rodriguez, Diana P. Deeg, Carol Hamelberg, Elizabeth
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Published in
Acta Neuropathologica Communications
Primary spinal cord tumors contribute to ≤ 10% of central nervous system tumors in individuals of pediatric or adolescent age. Among intramedullary tumors, spinal ependymomas make up ~ 30% of this rare tumor population. A twelve-year-old male presented with an intradural, extramedullary mass occupying the dorsal spinal canal from C6 through T2. Gro...
Lim, Ka Young Lee, Kwanghoon Shim, Yumi Park, Jin Woo Kim, Hyunhee Kang, Jeongwan Won, Jae Kyung Kim, Seung-Ki Phi, Ji Hoon Park, Chul-Kee
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Published in
Brain Tumor Pathology
Although ependymomas (EPNs) have similar histopathology, they are heterogeneous tumors with diverse immunophenotypes, genetics, epigenetics, and different clinical behavior according to anatomical locations. We reclassified 141 primary EPNs from a single institute with immunohistochemistry (IHC) and next-generation sequencing (NGS). Supratentorial ...
Dibs, Khaled Prasad, Rahul Neal Madan, Kajal Liu, Kevin Jiang, Will Ghose, Jayeeta Blakaj, Dukagjin M. Palmer, Joshua D. Kobalka, Peter Prevedello, Daniel M.
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Published in
Surgical Neurology International
Background: Ependymoma is an uncommon tumor accounting for approximately 1.9% of all adult central nervous system tumors. Ependymomas at the cerebellopontine angle (CPA) are even more rare and only previously described in isolated case reports. Typically, acoustic neuromas and meningiomas represent the bulk of adult CPA tumors. Diagnosis can be cha...
