Targeting C-terminal Helical bundle of NCOVID19 Envelope (E) protein
Published in International Journal of Biological Macromolecules
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Mutational insights into the envelope protein of SARS-CoV-2
Published in Gene Reports
The ongoing mutations in the structural proteins of SARS-CoV-2 are the major impediment for prevention and control of the COVID-19 disease. Presently we focused on evolution of the envelope (E) protein, one of the most enigmatic and less studied protein among the four structural proteins (S, E, M and N) associated with multitude of immunopathologic...
Structural and antigenic investigation of Usutu virus envelope protein domain III.
Published in Virology
The mosquito-borne flavivirus Usutu virus (USUV) has recently emerged in birds and humans in Europe. Symptoms of a USUV infection resemble those of West Nile virus (WNV); further, the close antigenic relationship of domain III (DIII) of the USUV and WNV envelope (E) proteins has prevented the development of a reliable serological test to distinguis...
SARS-CoV2 envelope protein: non-synonymous mutations and its consequences.
Published in Genomics
In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) ...
Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model.
...Published in Virologica Sinica
Zika virus (ZIKV) is emerging as a significant pathogen worldwide and may cause severe neurological disorders such as fetal microcephaly and Guillain-Barre syndrome. No drug or listed vaccines are currently available for preventing ZIKV infection. As a major target of neutralizing, ZIKV envelop (E) protein usually used for vaccine development. Neve...
Enhanced effect of modified Zika virus E antigen on the immunogenicity of DNA vaccine.
Published in Virology
It has been reported worldwide that the Zika virus (ZIKV) could be transmitted through placentas and sexual contact. ZIKV can also cause Guillain-Barre syndrome, microcephaly and neurological abnormalities. However, there are no approved vaccines available. We constructed six DNA vaccine candidates and tested the immunogenicity. Tandem repeated env...
Strong homology between SARS-CoV-2 envelope protein and a Mycobacterium sp. antigen allows rapid diagnosis of Mycobacter...
Published in Annals of diagnostic pathology
The vaccine BCG has been reported to offer protection against SARS-CoV-2 infection. It has been hypothesized this is based on nonspecific enhancement of innate immunity. This study addressed whether there is strong homology between a SARS-CoV-2 capsid protein and a Mycobacterium bovis protein that would allow for stronger, more specific immune prot...
The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection
...Published in Journal of Neuroinflammation
BackgroundTick-borne encephalitis virus (TBEV) is considered to be the medically most important arthropod-borne virus in Europe. The symptoms of an infection range from subclinical to mild flu-like disease to lethal encephalitis. The exact determinants of disease severity are not known; however, the virulence of the strain as well as the immune sta...
Molecular phylogeny and missense mutations of envelope proteins across coronaviruses.
Published in Genomics
Envelope (E) protein is one of the structural viroporins (76-109 amino acids) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were...
Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pat...
...Published in Microbes and Infection
The Envelope (E) protein of SARS-CoV-2 is the most enigmatic protein among the four structural ones. Most of its current knowledge is based on the direct comparison to the SARS E protein, initially mistakenly undervalued and subsequently proved to be a key factor in the ER-Golgi localization and in tight junction disruption. We compared the genomic...
