Liu, Lixian Xing, Liying Chen, Rongyuan Zhang, Jianing Huang, Yuye Huang, Lijuan Xie, Bingbing Ren, Xiangrong Wang, Shasha Kuang, Haiqing
...
Published in
Frontiers in Cell and Developmental Biology
The mitogen-inducible gene 6 (MIG6) is an adaptor protein widely expressed in vascular endothelial cells. However, it remains unknown thus far whether it plays a role in angiogenesis. Here, using comprehensive in vitro and in vivo model systems, we unveil a potent anti-angiogenic effect of MIG6 in retinal development and neovascularization and the ...
Chou, Chung-Hsing Modo, Michel
Published in
Brain research bulletin
Angiogenesis-mediated neovascularization correlates with recovery after intracerebral implantation of neural stem cells (NSCs) in stroke. To elucidate NSCs' mechanism of action, it is essential to understand how these interact with the brain's vasculature after implantation. Using an all-human endothelial cell (EC, D3 cell line) and NSC (STROC05 an...
Azimi, Mohammad S Motherwell, Jessica M Hodges, Nicholas A Rittenhouse, Garret R Majbour, Dima Porvasnik, Stacey L Schmidt, Christine E Murfee, Walter L
Published in
Microcirculation (New York, N.Y. : 1994)
Emerging areas of vascular biology focus on lymphatic/blood vessel mispatterning and the regulation of endothelial cell identity. However, a fundamental question remains unanswered: Can lymphatic vessels become blood vessels in adult tissues? Leveraging a novel tissue culture model, the objective of this study was to track lymphatic endothelial cel...
Mishra, Jay S. te Riele, Gigi M. Qi, Qian-Rong Lechuga, Thomas J. Gopalakrishnan, Kathirvel Chen, Dong-bao Kumar, Sathish
Published in
Hypertension (Dallas, Tex. : 1979)
The pregnancy-augmented uterine artery AT2R expression is stimulated by estrogens via endothelium-dependent gene transcription involving the enhanced expression of ERβ and its direct interaction with βEREs in AT2R promoter. This mechanism sheds new light on understanding the complex interactions of elevated estrogens and angiotensin II in pregnancy...
Di Rocco, Giuliana Baldari, Silvia Gentile, Antonietta Capogrossi, Maurizio Toietta, Gabriele
Published in
Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Di Rocco, Giuliana Baldari, Silvia Gentile, Antonietta Maurizio, Capogrossi Gabriele Toietta
Published in
Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Santoro, Massimo Mattia
Published in
Seminars in cell & developmental biology
Formation and maturation of a functional vascular network is a process called angiogenesis. This is a crucial biological event in all vertebrates. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Reactive oxygen species (ROS) and their metabolism are proving t...
Suarez-Martinez, Ariana D. Bierschenk, Susanne Huang, Katie Kaplan, Dana Bayer, Carolyn L. Meadows, Stryder M. Sperandio, Markus Murfee, Walter L.
Published in
Journal of Vascular Research
Background: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, th...
Brzica, Hrvoje Abdullahi, Wazir Reilly, Bianca G. Ronaldson, Patrick T.
Published in
Journal of Visualized Experiments : JoVE
The blood-brain barrier (BBB) is a dynamic barrier tissue that responds to various pathophysiological and pharmacological stimuli. Such changes resulting from these stimuli can greatly modulate drug delivery to the brain and, by extension, cause considerable challenges in the treatment of central nervous system (CNS) diseases. Many BBB changes that...
Gardner, Andrew W Montgomery, Polly S Zhao, Yan D Ungvari, Zoltan Csiszar, Anna Sonntag, William E
Published in
Angiology
We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance...
