Mishra, Jay S. te Riele, Gigi M. Qi, Qian-Rong Lechuga, Thomas J. Gopalakrishnan, Kathirvel Chen, Dong-bao Kumar, Sathish
Published in
Hypertension (Dallas, Tex. : 1979)
The pregnancy-augmented uterine artery AT2R expression is stimulated by estrogens via endothelium-dependent gene transcription involving the enhanced expression of ERβ and its direct interaction with βEREs in AT2R promoter. This mechanism sheds new light on understanding the complex interactions of elevated estrogens and angiotensin II in pregnancy...
Di Rocco, Giuliana Baldari, Silvia Gentile, Antonietta Capogrossi, Maurizio Toietta, Gabriele
Published in
Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Di Rocco, Giuliana Baldari, Silvia Gentile, Antonietta Maurizio, Capogrossi Gabriele Toietta
Published in
Stem Cell Research & Therapy
Background: Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after transplantation. Several strategies have been applied to increase transplanted cell survival but only with limited success. The endopl...
Santoro, Massimo Mattia
Published in
Seminars in cell & developmental biology
Formation and maturation of a functional vascular network is a process called angiogenesis. This is a crucial biological event in all vertebrates. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Reactive oxygen species (ROS) and their metabolism are proving t...
Suarez-Martinez, Ariana D. Bierschenk, Susanne Huang, Katie Kaplan, Dana Bayer, Carolyn L. Meadows, Stryder M. Sperandio, Markus Murfee, Walter L.
Published in
Journal of Vascular Research
Background: The development of models that incorporate intact microvascular networks enables the investigation of multicellular dynamics during angiogenesis. Our laboratory introduced the rat mesentery culture model as such a tool, which would be enhanced with mouse tissue. Since mouse mesentery is avascular, an alternative is mouse mesometrium, th...
Brzica, Hrvoje Abdullahi, Wazir Reilly, Bianca G. Ronaldson, Patrick T.
Published in
Journal of Visualized Experiments : JoVE
The blood-brain barrier (BBB) is a dynamic barrier tissue that responds to various pathophysiological and pharmacological stimuli. Such changes resulting from these stimuli can greatly modulate drug delivery to the brain and, by extension, cause considerable challenges in the treatment of central nervous system (CNS) diseases. Many BBB changes that...
Gardner, Andrew W Montgomery, Polly S Zhao, Yan D Ungvari, Zoltan Csiszar, Anna Sonntag, William E
Published in
Angiology
We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance...
Appukuttan, Binoy Ashander, Liam M. Ma, Yuefang Smith, Justine R.
Published in
Gene reports
Background Human retinal endothelial cells are employed increasingly for investigations of retinal vascular diseases. Analysis of gene expression response to disease-associated stimuli by reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) is common. However, most reported work does not follow the minimum information fo...
Nakatani, Satoru Murakami, Akira
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology
Hanini, Amel Massoudi, Mohamed El Gavard, Julie Kacem, Kamel Souad Ammar Souilem, Ouajdi
Published in
Environmental Toxicology and Pharmacology
The increasing use of engineered nanomaterials in commercial manufacturing and consumer products presents an important toxicological concern. Superparamagnetic zinc-cobalt ferrite nanoparticles (SFN) emerge as a promising tool for early cancer diagnostics and targeted therapy. However, toxicity and biological activities of SFN should be evaluated i...
