Hashimoto, Kenji
Published in
European archives of psychiatry and clinical neuroscience
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected individuals has conferred the viral spread with the status of global pandemic. However, there are no prophylactic or therapeutic drugs available on the market to treat COVID-19, althou...
Huang, Yang Ye, Zi Yin, Yujing Ma, Tianju Zhang, Qi Shang, Kun Chen, Wenqian Li, Zhaohui
Published in
Biochemical and biophysical research communications
Oxidative stress and endoplasmic reticulum (ER) stress are the key contributing factors for cataract progression. In our previous studies, we demonstrated that the nuclear factor erythroid 2-like-2 (Nrf-2)/heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis protects lens epithelial cells (LECs) against oxidants and ER stress. In the present study, tr...
Shi, Yingying Wang, Sijie Wu, Jialu Jin, Xizhi You, Jian
Published in
Journal of controlled release : official journal of the Controlled Release Society
Modern drug delivery system (DDS) exerts its unique superiority as to enhancing drug efficacy while reducing their toxicity, which relies heavily on an accurate route of delivery. Based on the fact that most drugs have their own specific target of action, increasing attention is paid to developing strategies for targeting certain tissues, cell line...
Zhao, Wei Liu, Jia-Xin Guo, Fang Liu, Xin-Guang
Published in
Mechanisms of ageing and development
Saccharomyces cerevisiae MED2/YDL005C is a subunit of the mediator complex (Mediator), which is responsible for tightly controlling the transcription of protein-coding genes by mediating the interaction of RNA polymerase II with gene-specific transcription factors. Although a high-throughput analysis in yeast showed that the MED2 protein exhibits a...
Fraternale, Alessandra Zara, Carolina Di Mambro, Tomas Manuali, Elisabetta Genovese, Domenica Anna Galluzzi, Luca Diotallevi, Aurora Pompa, Andrea De Marchis, Francesca Ambrogini, Patrizia
...
Published in
Biochimica et biophysica acta. Molecular basis of disease
Excessive production of immunoglobulins (Ig) causes endoplasmic reticulum (ER) stress and triggers the unfolded protein response (UPR). Hypergammaglobulinemia and lymphadenopathy are hallmarks of murine AIDS that develops in mice infected with the LP-BM5 murine leukemia retrovirus complex. In these mice, Th2 polarization and aberrant humoral respon...
Niwa, Maho
Published in
Biochimica et biophysica acta. Molecular cell research
The generation of new cells is one of the most fundamental aspects of cell biology. Proper regulation of the cell cycle is critical for human health, as underscored by many diseases associated with errors in cell cycle regulation, including both cancer and hereditary diseases. A large body of work has identified regulatory mechanisms and checkpoint...
Vance, Jean E.
Published in
Biology Direct
This article supplements a recent Perspective by Scorrano et al. in Nature Communications [10 [ (1)]:1287] in which the properties and functions of inter-organelle membrane contact sites were summarized. It is now clear that inter-organelle membrane contact sites are widespread in eukaryotic cells and that diverse pairs of organelles can be linked ...
Ren, Qun Brenner, Rebecca Boothby, Thomas C. Zhang, Zhaojie
Published in
BMC Microbiology
BackgroundAnhydrobiotes, such as the yeast Saccharomyces cerevisiae, are capable of surviving almost total loss of water. Desiccation tolerance requires an interplay of multiple events, including preserving the protein function and membrane integrity, preventing and mitigating oxidative stress, maintaining certain level of energy required for cellu...
Shokeen, Kamal Srivathsan, Ariktha Kumar, Sachin
Published in
Virus research
Newcastle disease is a severe clinical manifestation of avian species caused by Newcastle disease virus (NDV). Although several vaccination strategies are available to protect poultry against NDV infection, even then, outbreaks have been reported in the vaccinated birds. The lack of therapeutics against NDV makes the need for effective anti-viral d...
Chow-Shi-Yée, Mélanie Grondin, Melanie Ouellet, Francois Averill-Bates, Diana A
Published in
Cell stress & chaperones
Cryopreservation is used for long-term storage of cells and tissues. Cryoprotectants such as dimethyl disulfoxide (DMSO) are used to protect cells against freeze-thaw damage. Despite the use of cryoprotectants, hepatocytes are sensitive to stresses imposed by freeze and thaw processes, which cause physical damage, loss of functionality, or cell dea...
