Koscielny, Alicja Liszewska, Ewa Machnicka, Katarzyna Wezyk, Michalina Kotulska, Katarzyna Jaworski, Jacek
Published in
Cellular & Molecular Biology Letters
BackgroundMammalian/mechanistic target of rapamycin (mTOR) complexes are essential for cell proliferation, growth, differentiation, and survival. mTORC1 hyperactivation occurs in the tuberous sclerosis complex (TSC). mTORC1 localizes to the surface of lysosomes, where Rheb activates it. However, mTOR was also found on the endoplasmic reticulum (ER)...
McGrath, Eoghan P Centonze, Federica G Chevet, Eric Avril, Tony Lafont, Elodie
Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR) and aims at restoring ER homeostasis. However, if...
Santos, Herbert J Nozaki, Tomoyoshi
Published in
Parasitology international
A key characteristic of eukaryotic cells is the presence of organelles with discrete boundaries and functions. Such subcellular compartmentalization into organelles necessitates platforms for communication and material exchange between each other which often involves vesicular trafficking and associated processes. Another way is via the close appos...
Xia, Shengkai Duan, Wenzhe Liu, Wenwen Zhang, Xinri Wang, Qi
Published in
Journal of Translational Medicine
Glucose-regulating protein 78 (GRP78) is a molecular chaperone in the endoplasmic reticulum (ER) that promotes folding and assembly of proteins, controls the quality of proteins, and regulates ER stress signaling through Ca2+ binding to the ER. In tumors, GRP78 is often upregulated, acting as a central stress sensor that senses and adapts to change...
Gao, Yuan Xiong, Juan Chu, Qing-Zhu Ji, Wei-Ke
Published in
Journal of cell science
Membrane contact sites (MCSs) between endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While recent studies show that synaptotagmin-like mitochondrial-lipid-binding (SMP) domain-containing protein PDZD8...
Fessart, Delphine de Barbeyrac, Claire Boutin, Ines Grenier, Thomas Richard, Elodie Begueret, Hughes Bernard, David Chevet, Eric Robert, Jacques Delom, Frederic
...
The human Anterior GRadient 2 (AGR2) protein is an Endoplasmic Reticulum (ER)-resident protein which belongs to the Protein-Disulfide Isomerase (PDI) superfamily and is involved to productive protein folding in the ER. As such AGR2, often found overexpressed in adenocarcinomas, contributes to tumour development by enhancing ER proteostasis. We prev...
Persaud, Avinash K. Nair, Sreenath Rahman, Md Fazlur Raj, Radhika Weadick, Brenna Nayak, Debasis McElroy, Craig Shanmugam, Muruganandan Knoblaugh, Sue Cheng, Xiaolin
...
Published in
Nature Communications
Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid transport in erythroid progenitors leading to ER stress, and anaemia.
O'Keefe, Sarah Roboti, Peristera Duah, Kwabena B. Zong, Guanghui Schneider, Hayden Shi, Wei Q. High, Stephen
Published in
Journal of Cell Science
Summary: Ipomoeassin-F blocks the Sec61-dependent translocation of SARS-CoV-2 proteins into and across the endoplasmic reticulum, highlighting the potential of Sec61 inhibitors as antiviral agents.
Bruno, Sierra R. Anathy, Vikas
Published in
Histochemistry and Cell Biology
It has long been appreciated that the endoplasmic reticulum (ER) and mitochondria, organelles important for regular cell function and survival, also play key roles in pathogenesis of various lung diseases, including asthma, fibrosis, and infections. Alterations in processes regulated within these organelles, including but not limited to protein fol...
Zhang, Jing Yu, Xinru Zhang, Chaojun Zhang, Qiong Sun, Ying Zhu, Heqin Tang, Canming
Published in
Journal of hazardous materials
Verticillium wilt caused by Verticillium dahliae Kleb. is a major disease in cotton. We found that pectin lyase can enhance cotton resistance to Verticillium wilt and induce cell apoptosis of V. dahliae strain Vd080. The biocontrol effect of pectin lyase on Vd080 reached 61.9%. Pectin lyase increased ERG4 (Delta (24 (24 (1)))-sterol reductase) expr...
