The changing landscape of scientific communication at EASD
status: published
Response to Letter to the Editor From Sumi et al: "Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compa...
status: published
Enhanced endosomal signaling and desensitization of GLP-1R versus GIPR in pancreatic beta cells
The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of type 2 diabetes (T2D) and obesity. They are expressed in pancreatic beta cells where they potentiate insulin release in response to food intake. Despite GIP being the ...
Women in diabetes research: we can do better. Reply to Bonnefond A [letter]
status: accepted
American Indian Alaska Native (AIAN) adolescents and obesity: the influence of social determinants of health, mental hea...
...
ObjectiveTo explore the prevalence of obesity among American Indian and Alaska Native (AIAN) adolescents aged 12-19 years in association with social determinants of health (SDOH), and mental health and substance use disorders.MethodsGuided by the World Health Organization's Social Determinants of Health Framework, we examined data from the Indian H...
Physiological functions and potential clinical applications of motilin
Motilin is a gastrointestinal hormone secreted by the duodenum. This peptide regulates a characteristic gastrointestinal contraction pattern, called the migrating motor complex, during the fasting state. Motilin also affects the pressure of the lower esophageal sphincter, gastric motility and gastric accommodation in the gastrointestinal tract. Fur...
High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench
...
Monogenic high bone mass (HBM) disorders are characterized by an increased amount of bone in general, or at specific sites in the skeleton. Here, we describe 59 HBM disorders with 50 known disease-causing genes from the literature, and we provide an overview of the signaling pathways and mechanisms involved in the pathogenesis of these disorders. B...
ERα/ERβ-directed CBS transcription mediates E2β-stimulated hUAEC H2S production.
Elevated endogenous estrogens stimulate human uterine artery endothelial cell (hUAEC) hydrogen sulfide (H2S) production by selectively upregulating the expression of H2S synthesizing enzyme cystathionine β-synthase (CBS), but the underlying mechanisms are underdetermined. We hypothesized that CBS transcription mediates estrogen-stimulated pregnancy...
Hyperglycaemia following immune checkpoint inhibitor therapy-Incidence, aetiology and assessment
Aims We systematically studied the presence of hyperglycaemia during treatment with Immune Checkpoint Inhibitors (ICPI) for cancer, in those with and without diabetes at baseline, and determined the cause of new-onset hyperglycaemia, Methods Retrospective review of electronic records of those receiving an ICPI for melanoma, lung or renal cancer. Re...
Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins.
...
Microproteins (MPs) are a potentially rich source of uncharacterized metabolic regulators. Here, we use ribosome profiling (Ribo-seq) to curate 3,877 unannotated MP-encoding small ORFs (smORFs) in primary brown, white, and beige mouse adipocytes. Of these, we validated 85 MPs by proteomics, including 33 circulating MPs in mouse plasma. Analyses of ...
