Morthorst, Jane E Holbech, Henrik De Crozé, Noémie Matthiessen, Peter LeBlanc, Gerald A
Published in
Integrated environmental assessment and management
This review examines the presence and evolution of thyroid-like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing. Although arthropods including crustaceans do...
Jaegers, Jeremy Michaux, Caroline Ducenne, Audrey Gismondi, Eric Joaquim-Justo, Célia
peer reviewed / Short-Chain Chlorinated Paraffins (SCCPs) are ubiquitous, persistent chemicals which toxicity and potential impacts to aquatic ecosystems have been overlooked for many years. This study aims at determining the impact of these chemicals on rotifers. As sexual reproduction is often more sensitive to toxicants than amictic reproduction...
Olker, Jennifer H Korte, Joseph J Haselman, Jonathan T Hornung, Michael W Degitz, Sigmund J
Published in
Aquatic toxicology (Amsterdam, Netherlands)
The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical disruption of proteins relevant to thyroid signaling pathways. Iodotyrosine deiodinase (IYD), the iodi...
Li, Xixi Gu, Wenwen Zhang, Baiyu Xin, Xiaying Kang, Qiao Yang, Min Chen, Bing Li, Yu
Published in
Environment international
This study explored the combined disruption mechanism of polychlorinated naphthalenes (PCNs) on the three key receptors (estrogen receptor, thyroid receptor, and adrenoceptor) of the human endocrine system. The intensity of PCN endocrine disruption on these receptors was first determined using a molecular docking method. A comprehensive index of PC...
Xu, Ruiyi Pan, Luqing Zhou, Yueyao Gao, Zhongyuan Miao, Jingjing Yang, Yingying Li, Dongyu
Published in
Environmental science and pollution research international
Reproductive toxicity induced by benzo[a]pyrene (B[a]P) exposure has received great ecotoxicological concerns. However, huge gaps on the molecular mechanism still exist in bivalves. In this study, reproduction-related indicators were investigated in female scallops Chlamys farreri during life cycle of proliferative, growth, mature, and spawn stages...
Ravichandran, Janani Karthikeyan, Bagavathy Shanmugam Samal, Areejit
Published in
The Science of the total environment
An adverse outcome pathway (AOP) is a compact representation of the available mechanistic information on observed adverse effects upon environmental exposure. Sharing of events across individual AOPs has led to the emergence of AOP networks. Since AOP networks are expected to be functional units of toxicity prediction, there is current interest in ...
Orton, Frances Mangan, Stephanie Newton, Laura Marianes, Alexis
Published in
Environmental science and pollution research international
Amphibians are threatened globally with at least 43% of species declining and the most important stressor being habitat loss or degradation. Amphibians inhabiting highly biodiverse tropical regions are disproportionately threatened; however, the effects of landscape alterations on amphibian health are virtually unknown. In this study, we utilised n...
Singh, Pushpa Metkari, Siddhanath M Bhartiya, Deepa
Published in
Stem cell reviews and reports
It is generally believed that ovarian hormones regulate uterine functions and their altered levels result in various uteropathies like non-receptive uterus, endometrial hyperplasia, adenomyosis, endometriosis, leiomyomas and cancer. Uterus harbors two populations of stem cells including pluripotent, very small embryonic-like stem cells (VSELs) and ...
Jaegers, Jeremy Ducenne, Audrey Michaux, Caroline Gismondi, Eric Joaquim-Justo, Célia
peer reviewed / Rotifers are ubiquitous aquatic organisms which form one of the most populous zooplankton classes. Their efficient grazing of phytoplankton and high reproduction and turnover rates enable rapid nutrient cycling which feeds the upper levels of the food chain, making them a vital element of aquatic ecosystems. Furthermore, their small...
Carstensen, Lale Beil, Stephan Börnick, Hilmar Stolte, Stefan
Published in
Journal of hazardous materials
Benzophenone-type UV filters (BPs) represent a very diverse group of chemicals that are used across a range of industrial sectors around the world. They are found within different environmental compartments (e.g. surface water, groundwater, wastewater, sediments and biota) at concentrations ranging from ng/L to mg/L. Some are known as endocrine dis...
