Pagano, Livio Salmanton-García, Jon Marchesi, Francesco Blennow, Ola Gomes da Silva, Maria Glenthøj, Andreas van Doesum, Jaap Bilgin, Yavuz M López-García, Alberto Itri, Federico
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Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult patients with HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were incl...
Bender Ignacio, Rachel A Wohl, David A Arends, Rosalin Pilla Reddy, Venkatesh Mu, Ying Javan, Arzhang Cyrus Hughes, Michael D Eron, Joseph J Currier, Judith S Smith, Davey
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AZD7442 (Evusheld) is a combination of two human anti-severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs), tixagevimab (AZD8895) and cilgavimab (AZD1061). Route of administration is an important consideration to improve treatment access. We assessed pharmacokinetics (PKs) of AZD7442 absorption following 600 mg ...
Price, Morgan N Arkin, Adam P
A protein's function depends on functional residues that determine its binding specificity or its catalytic activity, but these residues are typically not considered when annotating a protein's function. To help biologists investigate the functional residues of proteins, we developed two interactive web-based tools, SitesBLAST and Sites on a Tree. ...
Santos, Lucianna H Kronenberger, Thales Almeida, Renata G Silva, Elany B Rocha, Rafael EO Oliveira, Joyce C Barreto, Luiza V Skinner, Danielle Fajtová, Pavla Giardini, Miriam A
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The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (Mpro) and papain-like protease (PLpro) are attractive drug targets among coronaviruses due to their essential role in processing the polyproteins translated from the viral RNA. In this study, we virtually scree...
Koenig, Kristi L Beÿ, Christian K Marty, Aileen M
Monkeypox 2022, a zoonotic virus similar to smallpox, presented as a rapidly escalating human outbreak with community transmission outside endemic regions of Africa. In just over one month of detection, confirmed cases escalated to over 3300, with reports of patients in at least 43 non-African nations. Mechanisms of transmission in animals and the ...
Miljkovic, Miloš D Tuia, Jordan E Olivier, Timothée Haslam, Alyson Prasad, Vinay
This cross-sectional study estimates all US Food and Drug Administration anticancer approvals in recent years and evaluates if an association exists between their cost and efficacy.
Valasek, Chad J Streuli, Samantha A Pines, Heather A Mittal, Maria Luisa Strathdee, Steffanie A Vera, Carlos F Harvey-Vera, Alicia Bazzi, Angela R
BackgroundPeople who inject drugs (PWID) face increased risk of SARS-CoV-2 acquisition and severe disease, yet COVID-19 vaccine uptake has been suboptimal. To inform vaccination interventions tailored for the needs of this population, we explored COVID-19 vaccination acceptability and experiences among PWID in San Diego County, USA.MethodsFrom Sept...
Pomraning, Kyle R Dai, Ziyu Munoz, Nathalie Kim, Young-Mo Gao, Yuqian Deng, Shuang Lemmon, Teresa Swita, Marie S Zucker, Jeremy D Kim, Joonhoon
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The global regulator LaeA controls secondary metabolism in diverse Aspergillus species. Here we explored its role in regulation of itaconic acid production in Aspergillus pseudoterreus. To understand its role in regulating metabolism, we deleted and overexpressed laeA, and assessed the transcriptome, proteome, and secreted metabolome prior to and d...
Kenneally, Ryan Lawrence, Quentin Brydon, Ella Wan, Kenneth H Mao, Jian-Hua Verma, Subhash C Khazaieli, Amir Celniker, Susan E Snijders, Antoine M
SARS-CoV-2 spread rapidly, causing millions of deaths across the globe. As a result, demand for medical supplies and personal protective equipment (PPE) surged and supplies dwindled. Separate entirely, hospital-acquired infections have become commonplace and challenging to treat. To explore the potential of novel sterilization techniques, this stud...
Shmeleva, Evgeniya V Syafiq, Danial Moldoveanu, Ana L Ferguson, Brian J Smith, Geoffrey L
Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene N1L (vΔN1) results in smaller skin lesions than infection with wild-type virus (WT VACV), but the impact of N1 deletion on the local microbiota as well as the innate and cel...