We aimed to synthesize the evidence from randomized controlled trials (RCTs) that determined the efficacy of adding omega-3 supplementation to the continuous sertraline therapy in adults with depression. Meta-analyses were performed using random effects. We used the Revised Cochrane risk of bias tool for randomized trials version 2.0. to assess the...
Prostaglandins, leukotrienes, and essential fatty acids
Previous studies have suggested that omega-3 polyunsaturated fatty acids (n-3 PUFA) can favorably influence cardiac autonomic tone. However, data regarding n-3 PUFA status and heart rate recovery (HRR) in healthy adults are sparse. To examine the association between n-3 PUFA status and HRR. Participants included 13,912 patients who underwent a comp...
• Covid-19 disease is responsible for cytokine storm and systemic inflammation. • Omega-3 PUFA are precursors of specialized pro-resolving lipid mediators. • Omega-3 PUFA could modulate the Covid-19 anti-inflammatory response. • Clinical trials should evaluate the effect of omega-3 PUFA in Covid-19 patients.
Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(医学) / 甲第22827号 / 医博第4666号 / 新制||医||1047(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 井上 治久, 教授 髙橋 良輔, 教授 Shohab YOUSSEFIAN / 学位規則第4条第1項該当
Journal of the International Society of Sports Nutrition
BackgroundLong-chain n-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may alter oxidative status and immune function after exercise. The aim of this pilot study was to determine the probable association between n-3 supplementation and physical exercise, observing the variations in markers of oxida...
Current Diabetes Reports
Purpose of ReviewEpidemiological studies have long suggested the cardiovascular benefits of omega-3 fatty acids (OM3FAs). However, until recently, clinical trials using OM3FAs have been largely negative with respect to their cardioprotective effects. In this review, we aim to summarize key clinical trials, examine the clinical benefits of eicosapen...
American Journal of Preventive Cardiology
• Hypertriglyceridemia is associated with atherogenesis & cardiovascular event risk. • Most triglyceride treatment cardiovascular outcomes trials have been negative. • However, icosapent ethyl significantly reduced cardiovascular events in REDUCE-IT. • Effects of icosapent ethyl beyond triglyceride reduction may play a role.
Bioprocess and biosystems engineering
Dissolved oxygen and pH are critical factors influencing cell growth and metabolism. In our previous work, we constructed the recombinant strain Mortierella alpina CCFM698, which has the ability to produce EPA at room temperature. However, our experiments showed that the dissolved oxygen produced by the aeration and agitation of the fermenter was i...
Journal of Atherosclerosis and Thrombosis
Aims: The ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) is related to major adverse events and death in cardiovascular diseases. The association between long-term prognosis of ischemic stroke and EPA/AA ratio has not been clarified. Methods: Acute ischemic stroke patients who had undergone blood examinations for polyunsaturated fatt...
Iranian Journal of Basic Medical Sciences
Objective(s): Adipose tissue is one of the most important endocrine organs that liberates many metabolic mediators such as hormones, cytokines, and chemokines. Different types of fatty acids have key roles in adipogenesis. The aim of this study was to evaluate the effects of two essential fatty acids, including Arachidonic acid (AA) and Eicosapenta...