Is political radicalization a product of increased issue position polarization, by which left and right-wing attitudes become ever more extreme? We argue that this is not the best explanation. Indeed, radical left and right supporters are not so much "left" or "right" in terms of their ideological attitudes. Instead, we argue that political cynicis...
The authors examined the contrasting factors behind the distinct increases in hot days (HDs, daytime hot extremes) and warm nights (WNs, nighttime hot extremes) over land in the Northern Hemisphere during the boreal summers (June to August) of 1980?2018. While the occurrence of HDs has increased gradually since 1980, that of WNs increased abruptly ...
Published in Cancer medicine
Prognosis of recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) remains poor. The addition of cetuximab, to platinum and fluorouracil chemotherapy (EXTREME regimen) has been shown to improve patients' outcomes in first-line settings. We conducted a retrospective, multicenter study, including HNSCC that progressed after a fi...
Orography is known to affect local meteorological conditions by inducing orographic rainfall and a rain shadow i.e. reduced rainfall on the mountain's leeside with respect to the windward side. Therefore it has a strong effect on the local population and agriculture. Recent work highlights the ambiguities in the definition and difficulties in quant...
Sint Maarten is a Caribbean island that is located in one of the six tropical zones were hurricanes may develop each year. The island deals with a limited resilient housing stock due to the lack of building regulations and affordable materials and contractors. This results in a community that needs to rebuild the housing stock every time a hurrican...
Introduction : le pronostic des carcinomes épidermoïdes récidivants ou métastatiques (R/M) de la tête et du cou (CETEC) reste médiocre. Il a été démontré que l'ajout de cetuximab, un inhibiteur de l'EGFR, à la chimiothérapie par platine et fluorouracile (régime EXTREME) améliore la survie sans progression (SSP), la survie globale (SG) et le taux de...
Published in Science (New York, N.Y.)
Increased concentrations of atmospheric greenhouse gases have led to a global mean surface temperature 1.0°C higher than during the pre-industrial period. We expand on the recent IPCC Special Report on global warming of 1.5°C and review the additional risks associated with higher levels of warming, each having major implications for multiple geogra...
Published in Frontiers in Oncology
The addition of cetuximab to platinum-based chemotherapy (cisplatin or carboplatin plus 5-fluorouracil [5-FU]), followed by maintenance cetuximab until disease progression (EXTREME), resulted in the first regimen to yield significantly improved survival outcomes in the first-line treatment of patients with recurrent and/or metastatic squamous cell ...
Published in Oncotarget
The EXTREME protocol is the standard of care for recurrent or metastatic head and neck squamous-cell carcinoma (R/M HNSCC) in first line. Beyond the first-line except immunotherapy, poor efficacy was reported by second-line chemotherapy. Re-challenge strategies based on a repetition of the first line with platinum and cetuximab regimens might have ...
Published in Annals of oncology : official journal of the European Society for Medical Oncology
B490 (EudraCT# 2011-002564-24) is a randomized, phase 2b, noninferiority study investigating the efficacy and safety of first-line cetuximab plus cisplatin with/without paclitaxel (CetCis versus CetCisPac) in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). Eligible patients had confirmed R/M SCCHN...
