Ding, Bi-Yue Xie, Xiu-Cheng Shang, Feng Smagghe, Guy Niu, Jin-Zhi Wang, Jin-Jun
Published in
Insect science
Carotenoids are involved in many essential physiological functions and are produced from geranylgeranyl pyrophosphate through synthase, desaturase, and cyclase activities. In the pea aphid (Acyrthosiphon pisum), the duplication of carotenoid biosynthetic genes, including carotenoid synthases/cyclases (ApCscA-C) and desaturases (ApCdeA-D), through h...
Van Hove, Lisette Hoste, Esther
Published in
The Journal of investigative dermatology
Fibroblasts have emerged as a dominant component of the tumor microenvironment, but despite the surging interest in the activation of fibroblasts and their role in cancer, they remain an elusive and complex cell type. In this perspective, we discuss the phenotypic plasticity of cancer-associated fibroblasts (CAFs) in melanoma and nonmelanoma skin c...
Højland, Allan Thomas Tavernier, Lisse J M Schrauwen, Isabelle Sommen, Manou Topsakal, Vedat Schatteman, Isabelle Dhooge, Ingeborg Huber, Alex Zanetti, Diego Kunst, Henricus P M
...
Published in
Human genetics
In this study, we investigated the association of ACAN variants with otosclerosis, a frequent cause of hearing loss among young adults. We sequenced the coding, 5'-UTR and 3'-UTR regions of ACAN in 1497 unrelated otosclerosis cases and 1437 matched controls from six different subpopulations. The association between variants in ACAN and the disease ...
Wohlmuth, Christoph; Djedovic, Vladimir; Kjaer, Susanne K; Jensen, Allan; Glasspool, Rosalind; Roxburgh, Patricia; DeFazio, Anna; Johnatty, Sharon E; Webb, Penelope M; Modugno, Francesmary;
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OBJECTIVE: Studies on low-grade serous ovarian cancer (LGSC) are limited by a low number of cases. The aim of this study was to define the prognostic significance of age, stage, and CA-125 levels on survival in a multi-institutional cohort of women with pathologically confirmed LGSC. METHODS: Women with LGSC were identified from the collaborative O...
Liu, D Yang, QZC Asim, M Krell, J Frampton, A
Extracellular vesicles (EVs) are important for intercellular signalling in multi-cellular organ-isms. However, the role of mature transfer RNAs (tRNAs) and tRNA fragments in EVs has yet to be characterised. This systematic review aimed to identify up-to-date literature on tRNAs pre-sent within human EVs and explores their potential clinical signifi...
DiFrisco, James; 75358; Wagner, Guenter P;
status: published
Bae, Sungjun Lim, Hyun-Kyoung Jeong, Yoonyi Kim, Seong-Gi Park, Sung-Min Shon, Young-Min Suh, Minah
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has been widely used as an effective treatment for refractory temporal lobe epilepsy. Despite its promising clinical outcome, the exact mechanism of how ANT-DBS alleviates seizure severity has not been fully understood, especially at the cellular level. To assess effects of ...
Salazar-Tortosa, Diego F Pascual-Gamarra, José M Labayen, Idoia Rupérez, Azahara I Censi, Laura Béghin, Laurent Michels, Nathalie González-Gross, Marcela Manios, Yannis Lambrinou, Christina-Paulina
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Published in
Pediatric research
The aim of this study was to investigate the association of endothelial lipase gene (LIPG) polymorphisms with cardiovascular disease (CVD) risk factors in adolescents and their interaction with physical activity. Six polymorphisms of LIPG were genotyped in 1057 European adolescents (12-18 years old) enrolled in the Healthy Lifestyle in Europe by Nu...
Iantcheva, Anelia Zhiponova, Miroslava Revalska, Miglena Heyman, Jefri Dincheva, Ivayla Badjakov, Ilian De Geyter, Nathan Boycheva, Irina Goormachtig, Sofie De Veylder, Lieven
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Published in
Protoplasma
The F-box domain is a conserved structural protein motif that most frequently interacts with the SKP1 protein, the core of the SCFs (SKP1-CULLIN-F-box protein ligase) E3 ubiquitin protein ligases. As part of the SCF complexes, the various F-box proteins recruit substrates for degradation through ubiquitination. In this study, we functionally charac...
Geysen, Astrid; Goffin, Karolien; 50420; Van Weehaeghe, Donatienne; Van Laere, Koen; 40740; Deroose, Christophe M; 40937;
ABSTRACT: Two women were referred for an 18F-PSMA-1007 PET/CT in follow-up of an adenoid cystic tumor of the subglottic region and the bronchus, respectively. Only limited tracer uptake was seen in the region of local recurrence and in the region of known metastases. Unexpectedly, an incidental finding consisting of a high tracer uptake at a corpus...
