Kahler, Jan Pascal; Aloi, Vincenzo Davide; Aliaga, Julia Miedes; Kerselaers, Sara; Voets, Thomas; Vriens, Joris; 35360; Verhelst, Steven HL; 100754; Barniol-Xicota, Marta;
TRPM3 is an ion channel that is highly expressed in nociceptive neurons and plays a key role in pain perception. In the presence of the endogenous TRPM3 ligand, pregnenolone sulfate (PS), the antifungal compound clotrimazole (Clt) augments Ca2+ signaling and opens a non-canonical pore, permeable to Na+, which aggravates TRPM3-induced pain. To date,...
Li, Xiaoji Sun, Leiming Huang, Jiemei Zeng, Fanze
Published in
Sensors (Basel, Switzerland)
In underwater wireless optical communication (UWOC), a vortex beam carrying orbital angular momentum has a spatial spiral phase distribution, which provides spatial freedom for UWOC and, as a new information modulation dimension resource, it can greatly improve channel capacity and spectral efficiency. In a case of the disturbance of a vortex beam ...
Van Thillo, Toon; 125381; Van Deuren, Vincent; 111168; Dedecker, Peter; 46850;
Genetically-encoded biosensors provide the all-optical and non-invasive visualization of dynamic biochemical events within living systems, which has allowed the discovery of profound new insights. Twenty-five years of biosensor development has steadily improved their performance and has provided us with an ever increasing biosensor repertoire. In t...
Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; de Kok, Theo M; Nawrot, Tim S; 34994;
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status: published
Chou, Jonathan Egusa, Emily A. Wang, Sinan Badura, Michelle L. Lee, Fei Bidkar, Anil P. Zhu, Jun Shenoy, Tanushree Trepka, Kai Robinson, Troy M.
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Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3 (DLL3) is expressed in de novo and t-SCNC and is associated with reduced survival. We develop a PET...
Huang, Shouguang Maierhofer, Tobias Hashimoto, Kenji Xu, Xiangyu Karimi, Sohail M. Müller, Heike Geringer, Michael A. Wang, Yi Kudla, Jörg De Smet, Ive
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Guard cells control the opening of stomatal pores in the leaf surface, with the use of a network of protein kinases and phosphatases. Loss of function of the CBL-interacting protein kinase 23 (CIPK23) was previously shown to decrease the stomatal conductance, but the molecular mechanisms underlying this response still need to be clarified. CIPK23 w...
Anders, Chantal Hoengenaert, Lennart Boerjan, Wout
The high economic value of wood requires intensive breeding towards multipurpose biomass. However, long breeding cycles hamper the fast development of novel tree varieties that have improved biomass properties, are tolerant to biotic and abiotic stresses, and resilient to climate change. To speed up domestication, the integration of conventional br...
Lunardi, Francesca; Abbrescia, Daniela Isabel; Vedovelli, Luca; Pezzuto, Federica; Fortarezza, Francesco; Comacchio, Giovanni Maria; Guzzardo, Vincenza; Ferrigno, Pia; Loy, Monica; Giraudo, Chiara;
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Chronic rejection (CR) is the main culprit for reduced survival and quality of life in patients undergoing lung transplantation (Ltx). High-throughput approaches have been used to unveil the molecular pathways of CR, mainly in the blood and/or in bronchoalveolar lavage. We hypothesized that a distinct molecular signature characterizes the biopsies ...
Soutar, Marc PM; Melandri, Daniela; O'Callaghan, Benjamin; Annuario, Emily; Monaghan, Amy E; Welsh, Natalie J; D'Sa, Karishma; Guelfi, Sebastian; Zhang, David; Pittman, Alan;
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Parkinson's disease is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies has considerably advanced our understanding of the Parkinson's disease genetic risk. Understanding the functional significance of the risk loci is now a critical step towards translating these genetic advan...
Kang, Wonok Ju, Chanyang Joo, Jaesoon Lee, Jiho Shon, Young-Min Park, Sung-Min
Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here, in a rat model, we report a sequential narrow-fi...