Iwahori, Toshiyuki Miura, Katsuyuki Ueshima, Hirotsugu Tanaka-Mizuno, Sachiko Chan, Queenie Arima, Hisatomi Dyer, Alan R Elliott, Paul Stamler, Jeremiah
Published in
Hypertension research : official journal of the Japanese Society of Hypertension
The Na/K ratio may be more strongly related to blood pressure and cardiovascular disease than sodium or potassium. The casual urine Na/K ratio can provide prompt on-site feedback, and with repeated measurements, may provide useful individual estimates of the 24-h ratio. The World Health Organization has published guidelines for sodium and potassium...
Costas Rodriguez, Marta Van Campenhout, Sanne Hastuti, Agustina Ari Murti Budi Devisscher, Lindsey Van Vlierberghe, Hans Vanhaecke, Frank
Patients with chronic liver disease from different aetiologies show a light serum Cu isotopic composition compared to the reference population, with the enrichment in the Cu-63 isotope correlating with the severity of the disease. However, the mechanisms underlying Cu isotope fractionation at the onset and during progression of the disease are stil...
Coussement, Louis Bolca, Selin Van Criekinge, Wim Trooskens, Geert Mensaert, Klaas Poels, Katrien Roche, Nathalie Blondeel, Phillip Godderis, Lode Depypere, Herman
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Upon soy consumption, isoflavone metabolites attain bioactive concentrations in breast tissue possibly affecting health. Though in vitro epigenetic activity of soy metabolites has been described, the in vivo impact on the epigenome is largely unknown. Therefore, in this case-control study, the breast glandular tissue DNA methylome was explored in w...
Wen, X Zhou, L Stamler, J Chan, Q Van Horn, L Daviglus, ML Dyer, AR Elliott, P Ueshima, H Miura, K
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OBJECTIVE: The present study aims to compare 24-h dietary recalls with 24-h urine collections for the estimation of sodium intake at both population and individual levels in China, Japan, the United Kingdom (UK), and the United States of America (USA), using data from the International Study of Macro- and Micro-nutrients and Blood Pressure (INTERMA...
Pazoki, Raha Dehghan, Abbas Evangelou, Evangelos Warren, Helen Gao, He Caulfield, Mark Elliott, Paul Tzoulaki, Ioanna
Published in
Circulation
High blood pressure (BP) is a major risk factor for cardiovascular diseases (CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors contribute to elevated BP levels. We aimed to investigate the extent to which lifestyle factors could offset the effect of an adverse BP genetic profile and its effect on CVD risk. W...
Neal, BC Yin, X Tian, M Li, Z Petersen, K Komatsu, Y Feng, X Wu, Y
Objectives: Measurement of mean population sodium and potassium intake typically using laboratory -based assays which can add significant logistical burden and costs. A valid field-based measurement method would be a significant advance. In this study, we used 166 24 -hour urine collection samples to compare estimates of sodium, potassium content a...
Vanmassenhove, Jill Lameire, Norbert
This paper discusses the diagnostic and therapeutic approach to the problem of a young woman presenting with recurrent kidney stones. In the clinical work-up, a hypokalaemic normal anion gap metabolic acidosis was found. The diagnostic tests to solve this common clinical problem and some therapeutic recommendations are discussed. Question on hypoka...
Van Meulebroek, Lieven De Clercq, Nathalie Vanden Bussche, Julie Devreese, Mathias Fichant, Eric Delahaut, Philippe Croubels, Siska Vanhaecke, Lynn
Background: In Europe, synthetic corticosteroids are not allowed in animal breeding for growth-promoting purposes. Nevertheless, a high prevalence of non-compliant urine samples was recently reported for prednisolone, however, without any indication of unauthorized use. Within this context, 20 beta-dihydroprednisolone and the prednisolone/cortisol ...
Broekaert, Nathan Devreese, Mathias van Bergen, Thomas Schauvliege, Stijn De Boevre, Marthe De Saeger, Sarah Vanhaecke, Lynn Berthiller, Franz Michlmayr, Herbert Malachová, Alexandra
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Crossover animal trials were performed with intravenous and oral administration of deoxynivalenol-3-β-D-glucoside (DON3G) and deoxynivalenol (DON) to broiler chickens and pigs. Systemic plasma concentrations of DON, DON3G and de-epoxy-DON were quantified using liquid chromatography-tandem mass spectrometry. Liquid chromatography coupled to high-res...
Wauters, Jella Van Meulebroek, Lieven Fichant, E Delahaut, P Vanhaecke, Lynn
Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18...
