PURPOSE: Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women with pathologically confirmed ovarian carcinoma was conducted to examine the association betwee...
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
CXCL12 is abundantly expressed in reticular cells associated with the perivascular niches of the bone marrow (BM) and is indispensable for B lymphopoiesis. Cxcl12 promotes osteoclastogenesis and has been implicated in pathologic bone resorption. We had shown earlier that estrogen receptor α deletion in osteoprogenitors and estrogen deficiency in mi...
Published in Western journal of nursing research
Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high...
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA. Methods: The frequencies of monocyte subpopulations in the peripheral blood o...
Published in JBMR plus
Production of sphingosine-1-phosphate (S1P) is linked to 17β-estradiol (E2) activity in many estrogen-responsive cells; in bone development, the role of S1P is unclear. We studied effects of S1P on proliferation and differentiation of human osteoblasts (hOB). Ten nM E2, 1 μM S1P, or 1 μM of the S1P receptor 1 (S1PR1) agonist SEW2871 increased hOB p...
Published in Journal of Bone and Mineral Research
Estrogens play an important role in bone growth and maturation as well as in the regulation of bone turnover in adult s . Although the effects of 17β‐estradiol (E2) are well documented in long bones and vertebrae, little is known regarding its action in the mandible. E2 actions could be mediated by estrogen receptor (ER) α or β. ERs act primarily a...
The diagnosis of cryptorchidism in horses is often a challenge. Based on the history, clinical and rectal examinations and ultrasonography, a definitive diagnosis is not always possible. Various endocrinological diagnostic assays, such as the determination of testosterone, androstenedione, estrogens, urinary steroids and the anti-Mullerian hormone,...
This review article reflects the presentations and subsequent discussions during a think tank at the 5th International Consultation on Incontinence Research Society’s annual meeting, held in Bristol, UK (September 22–24, 2014). It reviews the current state of knowledge on the role of hormones in lower urinary tract dysfunction (LUTD) and overactive...
Published in Andrologia
Transwomen (TW) can now turn to cryopreserve spermatozoa before gender reassignment (GR). The objective is to assess semen quality of TW and evaluate adequacy for assisted reproduction technology (ART). Pre-freezing (PF) and post-thaw (PT) semen parameters of 2 and PF data of 27 TW who were referred for sperm banking in Cleveland Clinic/USA and Ghe...
Published in Water Environment Research
A review of the literature published in 2013 on topics relating to the fate of emerging environmental pollutants during wastewater treatment is presented. This review is divided into the following sections: emerging biological agents, estrogens, metals, nanomaterials, nutrients, persistent organic pollutants, pharmaceuticals and personal care produ...
