BackgroundGiven the established fact that obesity interferes with male reproductive functions, the present study aimed to evaluate sperm production in the testis and storage in the epididymis in a glutamate-induced model of obesity.MethodsMale rats were treated neonatally with monosodium glutamate (MSG) at doses of 4 mg/kg subcutaneously, or with s...
Perobelli, Juliana ElaineAlves, Thais ReginaToledo, Fabiola Choqueta deFernandez, Carla Dal BiancoFranci, Janete Aparecida AnselmoKlinefelter, Gary R.Kempinas, Wilma De Grava
National Council for Scientific and Technological Development (CNPq) [501339/2010-8]
Perobelli, Juliana ElaineAlves, Thais ReginaToledo, Fabiola Choqueta deFernandez, Carla Dal BiancoFranci, Janete Aparecida AnselmoKlinefelter, Gary R.Kempinas, Wilma De Grava
National Council for Scientific and Technological Development (CNPq) [501339/2010-8]
Perobelli, Juliana ElaineAlves, Thais ReginaToledo, Fabiola Choqueta deFernandez, Carla Dal BiancoFranci, Janete Aparecida AnselmoKlinefelter, Gary R.Kempinas, Wilma De Grava
National Council for Scientific and Technological Development (CNPq) [501339/2010-8]
Perobelli, Juliana ElaineAlves, Thais ReginaToledo, Fabiola Choqueta deFernandez, Carla Dal BiancoFranci, Janete Aparecida AnselmoKlinefelter, Gary R.Kempinas, Wilma De Grava
National Council for Scientific and Technological Development (CNPq) [501339/2010-8]
Fertilin alpha (ADAM-1) and beta (ADAM-2) are integral membrane proteins of the ADAM family that form a fertilin complex involved in key steps of the sperm-oocyte membrane interaction. In the present work, we analyzed the presence of ADAM-1 and ADAM-2 mRNAs, the spermatozoa proteins' processing and their sub-cellular localization in epididymal samp...
Belleannée, ClémenceLabas, ValérieTeixeira-Gomes, Ana PaulaGatti, Jean-LucDacheux, Jean-LouisDacheux, Françoise
The epididymis plays a major role in the acquisition of sperm fertility. In order to shed light on specific features of epididymal function in mammalian species, we characterized the luminal proteins (luminal proteome) and secreted proteins (secretome) in the bovine epididymis. We identified 172 different luminal proteins in 9 distinct epididymal r...
In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between several mammals could be an informat...
