Kilpatrick, Ryan D Chiuve, Stephanie E Leslie, William D Wegrzyn, Lani R Gao, Wei Yang, Hongbo Soliman, Ahmed M Snabes, Michael C Koenigsberg, Sarah Zhong, Jia
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Published in
JBMR Plus
Elagolix, a gonadotrophin‐releasing hormone antagonist, is used in premenopausal women with endometriosis. There is a risk of bone loss with elagolix, but the long‐term effects of BMD loss later in life cannot be directly assessed and has not been quantified. To address this gap in knowledge, this study indirectly estimated the impact of elagolix o...
Phelan, Catherine M Kuchenbaecker, Karoline B Tyrer, Jonathan P Kar, Siddhartha P Lawrenson, Kate Winham, Stacey J Dennis, Joe Pirie, Ailith Riggan, Marjorie J Chornokur, Ganna
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Published in
Nature genetics
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11...
Hollestelle, Antoinette van der Baan, Frederieke H Berchuck, Andrew Johnatty, Sharon E Aben, Katja K Agnarsson, Bjarni A Aittomäki, Kristiina Alducci, Elisa Andrulis, Irene L Anton-Culver, Hoda
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Published in
Gynecologic oncology
Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehen...
Ramos, Ivana Maria de Luna Podgaec, Sérgio Abrão, Mauricio Simões Oliveira, Ricardo de Baracat, Edmund Chada
OBJETIVO: Avaliar as concentrações séricas de CA-125 e CD-23 solúvel e correlacioná-los com sintomas clínicos, localização e estádio da endometriose pélvica e classificação histológica da doença. MÉTODOS: Amostras de sangue foram coletadas de 44 mulheres com endometriose e 58 sem endometriose durante os primeiros três dias (1ª amostra) e durante o ...
Reis, Fernando M. Luisi, Stefano Abrao, Mauricio S. Rocha, Ana Luiza L. Vigano, Paola Rezende, Carolina P. Florio, Pasquale Petraglia, Felice
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
Podgaec, Sérgio Rizzo, Luiz Vicente Cordeiro Fernandes, Luiz Flavio Baracat, Edmund Chada Abrão, Mauricio Simões
Problem To evaluate CD4+CD25highFoxp3+ cells and IL-6, IL-10, IL-17, and TGF-beta in the peritoneal fluid of women with endometriosis. Method of study A total of ninety-eight patients were studied: endometriosis (n = 70) and control (n = 28). First, peritoneal fluid lymphocytes were isolated, and CD4+CD25high cells were identified using flow cytome...
Silveira, Cassia G. T. Abrao, Mauricio S. Coudry, Renata A. Soares, Fernando A. Drigo, Sandra A. Domingues, Maria A. C. Rogatto, Silvia R.
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Podgaec, Sergio de Oliveira, Ricardo Manoel Carnevale Marin, Maria Lucia Baracat, Edmund Chadad Abrao, Mauricio Simoes
Sao Paulo State Foundation for the Support of Research [05/01218-3]
Podgaec, Sérgio Rizzo, Luiz Vicente Cordeiro Fernandes, Luiz Flavio Baracat, Edmund Chada Abrão, Mauricio Simões
Problem To evaluate CD4+CD25highFoxp3+ cells and IL-6, IL-10, IL-17, and TGF-beta in the peritoneal fluid of women with endometriosis. Method of study A total of ninety-eight patients were studied: endometriosis (n = 70) and control (n = 28). First, peritoneal fluid lymphocytes were isolated, and CD4+CD25high cells were identified using flow cytome...
Ramos, Ivana Maria de Luna Podgaec, Sérgio Abrão, Mauricio Simões Oliveira, Ricardo de Baracat, Edmund Chada
OBJETIVO: Avaliar as concentrações séricas de CA-125 e CD-23 solúvel e correlacioná-los com sintomas clínicos, localização e estádio da endometriose pélvica e classificação histológica da doença. MÉTODOS: Amostras de sangue foram coletadas de 44 mulheres com endometriose e 58 sem endometriose durante os primeiros três dias (1ª amostra) e durante o ...
