Celična terapija s CAR-T se je v preteklih letih izkazala za eno najobetavnejših novih terapij za zdravljenje malignih obolenj. Zaradi uporabe bolniku lastnih (avtolognih) celic, ki predstavljajo spremenljiv dejavnik, se pojavlja potreba po in vitro testiranju aktivnosti celic CAR-T pred vnosom v pacienta. V magistrski nalogi smo s pomočjo elektrop...
Published in BMC Veterinary Research
BackgroundGroup A rotaviruses (RVA) are zoonotic pathogens responsible for acute enteritis in human and neonatal ruminants. This research aimed to determine the prevalence of RVA in ruminants (cattle, sheep, and goats) and investigate the circulating RVA genotypes in these animals in Kuwait. We conducted a cross-sectional study to detect RVA in rum...
Published in Frontiers in Immunology
Type 1 diabetes (T1D) is an autoimmune disorder with unambiguous involvement of both innate and adaptive immune mechanisms in the destruction of pancreatic beta cells. Recent evidence demonstrated that neutrophils infiltrate the pancreas prior to disease onset and therein extrude neutrophil extracellular traps (NETs), web-like structures of DNA and...
Namen tega dela je bila optimizacija zaznave jajčnega proteina ovalbumina s testom ELISA v modelnih vzorcih proteinskih barv dveh bakrovih pigmentov – malahita in pigmenta verdigris. Gre za prvo poglobljeno in sistematično raziskavo v dediščinski znanosti, v kateri smo s spremljanjem koncentracije bakrovih ionov iz pigmentov barv poskušali razumeti...
Published in International health
Hydatid disease or cystic echinococcosis (CE) is caused by the larval stages of the cestode parasite Echinococcus granulosus. The objectives of this study were to estimate the prevalence of seropositivity and to identify the risk factors associated with the disease among humans in Khartoum State, Central Sudan. A cross-sectional study was conducted...
Published in Environmental science and pollution research international
Aflatoxins are one of the major environmental contaminants in animal feed and pose a potential threat to human health due to their secretion in the milk of lactating animals. The present study was conducted with the objectives to determine the occurrence of aflatoxins (B1, B2, G1, and G2) in dairy animal concentrate feed and to evaluate the effect ...
Published in British journal of biomedical science
Background: The objective of this study was to evaluate the performance characteristics of early commercial SARS-CoV-2 antibody assays in mild and asymptomatic subjects to enable the selection of suitable immunoassays for routine diagnostic use.Methods: We used serum samples from a pre-COVID era patient cohort (n = 50, pre-December 2019), designate...
Published in Journal of Clinical Virology
Background Most COVID-19 patients experience non-severe illness. The presence of SARS-CoV-2 antibodies suggest possible protection against re-infections in prior SARS-CoV-2 infected individuals. Objectives The aims of this prospective observational study were to longitudinally assess the antibody response during the first 4–6 months after polymeras...
Published in International Journal of General Medicine
Background Hepatitis B virus is a public health problem in the world. It is a major cause of chronic hepatitis, cirrhosis, and hepatic cellular carcinoma. The presence of a confirmed HBsAg result is indicative of ongoing HBV infection. This study aims to assess the sero-prevalence and associated factors of the hepatitis B virus among pregnant women...
Published in BMC Infectious Diseases
BackgroundDespite high childhood immunization coverage, sporadic cases of diphtheria have been reported in Malaysia in recent years. This study aims to evaluate the seroprevalence of diphtheria among the Malaysian population.MethodsA total of 3317 respondents age 2 years old to 60 years old were recruited in this study from August to November 2017....
