Fu, Wenyan Sun, Hefen Zhao, Yang Chen, Mengting Yang, Lipeng Yang, Xueli Jin, Wei
Published in
Molecular immunology
The overexpression of EGFR often occurs in TNBC, and the anti-EGFR receptor antibody cetuximab is used widely to treat metastatic cancer in the clinic. However, EGFR-targeted therapies have been developed for TNBC without clinical success. In this study, we show that impaired EGFR degradation is crucial for resistance to cetuximab, which depends on...
Hetmanski, Joseph H R Schwartz, Jean-Marc Caswell, Patrick T
Published in
Small GTPases
Precise spatiotemporal dynamics of Rho GTPases are essential for efficient cell migration. Manipulating Rac1 and RhoA signaling is thus a potential intervention strategy to abrogate harmful cell invasion and subsequent metastasis; however GTPase signaling can be extremely complicated due to crosstalk and the multitude of upstream regulators and dow...
Cheng, Chao Deng, Li Li, Rongxiu
Published in
Cellular Physiology and Biochemistry
Background/Aims: The abnormally activated EGFR promotes tumor growth, invasion and metastasis. Current therapeutics targeting EGFR have markedly improved the clinical outcome, but they are limited in use due to transient efficacy, frequent administration, high cost and significant toxicity. Methods: We rationally designed a multiepitope immunogen a...
You, Hui Meng, Kun Wang, Zhao-Yi
Published in
Steroids
Hepatocellular carcinoma (HCC) is the common primary liver cancer and the third leading cause of cancer related mortality worldwide. It is generally thought that the estrogen-signaling pathway is not related to the development and progression of human HCC. However, accumulating evidences indicate the existence of a rapid estrogen signaling in HCC c...
Jebali, Ahlem Dumaz, Nicolas
AbstractThe importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been known for many years but the central role of RICTOR (rapamycin-insensitive companion of mTOR) in this pathway is only starting to emerge. RICTOR is critical for mTO...
Vogel, Viola
Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in guiding developmental processes, tissue homeostasis, and aging has long been underestimated. How ECM orchestrates the deterioration of healthy to pathological tissues, including fibrosis and cancer, also remains poorly understood. Inquiring how alterations in...
Pandey, Manoj Kannepali, Krishna Kiran Dixit, Ruhi Kumar, Mohan
Published in
World journal of surgical oncology
The result of the present study shows significant downgrading of the oral cancers with neoadjuvant chemotherapy suggesting its utility in borderline operable cases. However, the response of chemotherapy does not appear to be related to the expression of EGFR, Her-2-Neu, and GADD45 protein or presence of HPV. Bone involvement, perineural invasion, a...
Gong, Xiaohui Du, Xianjin Xu, Yong Zheng, Wenze
Published in
Cellular Physiology and Biochemistry
Background/Aims: LINC00037 has previously been reported to be up-regulated in clear cell renal cell carcinoma (ccRCC), however, the underlying mechanism remained unknown. In this study, we designed to investigate the functional role of LINC00037 in ccRCC Methods: LINC00037 knockdown and re-expressing 786-O and A498 cells were established. CCK8 assa...
Zhang, Fan Ma, Xin Li, Hongzhao Zhang, Yu Li, Xintao Chen, Luyao Guo, Gang Gao, Yu Gu, Liangyou Xie, Yongpeng
...
Published in
International journal of cancer
Forkhead box K2 (FOXK2) belongs to the forkhead box transcription factor family. Recent studies have revealed that FOXK2 plays essential roles in cancer cell proliferation and survival. However, the biological function of FOXK2 in renal cell carcinoma remains unexplored. In our study, we demonstrated that FOXK2 mRNA and protein levels were decrease...
Frankel, Diane Nanni-Metellus, Isabelle Robaglia-Schlupp, Andrée Tomasini, Pascale Guinde, Julien Barlesi, Fabrice Astoul, Philippe Ouafik, L’Houcine Amatore, Florent Secq, Véronique
...
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Background: In lung adenocarcinoma, molecular profiling of actionable genes has become essential to set up targeted therapies. However, the feasibility and the relevance of molecular profiling from the cerebrospinal fluid (CSF) in the context of meningeal metastasis have been poorly assessed. Methods: We selected patients with stage IV lung adenoca...
