Ku, Gwan Woo Kang, Yujin Yu, Seong-Lan Park, Joonghoon Park, Sejin Jeong, In Beom Kang, Min Woong Son, Ji Woong Kang, Jaeku
Published in
BMC Cancer
BackgroundlncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has been found to be significantly down-regulated in mesenchymal-like lung cancer cell lines and directly regulated EGFR. In this wor...
Li, Huilan Xing, Shan Xu, Jianhua He, Yi Lai, Yanzhen Wang, Yu Zhang, Ge Guo, Songhe Deng, Min Zeng, Musheng
...
Published in
Talanta
Tumor-derived extracellular vesicles (TEVs) have emerged as promising sources of diagnostic and prognostic biomarkers for nasopharyngeal carcinoma (NPC). However, the lack of high-sensitivity analytic methods for ultratrace membrane proteins on TEVs hamper their clinical application of TEVs. Herein, by combining aptamers that specifically bind to p...
Ma, Jia-Xin Xiao, Xiong Zhou, Kai-Fang Huang, Gang Ao, Bo Zhang, Ying Gao, Wen-Jun Lei, Ting Yang, Li Fan, Xue-Cheng
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Published in
Journal of ethnopharmacology
Ephedrae Herba (EH, Ephedra sinica Stapf.) and Armeniacae Semen Amarum (ASA, Prunus armeniaca L. var. ansu Maxim.) have been used to treat asthma, cold, fever, and cough in China for thousands of years. In this study, we aimed to investigate the optimal ratio of EH and ASA compatibility (EAC) to reduce airway injury in asthmatic rats and its possib...
Rahmani, Zahra Safari, Fatemeh
Published in
Tissue & cell
Human amniotic mesenchymal stromal cells (hAMSCs) are considered as a population of multipotent cells. The molecular events associated with mesenchymal stromal cell (MSC)/tumor cell interactions should be studied to identify the role of MSCs on suppressing or inducing the key signaling pathways of tumor cells. Thus, designing therapeutic approaches...
Sartages, Miriam Floridia, Ebel García-Colomer, Mar Iglesias, Cristina Macía, Manuel Peñas, Patricia Couraud, Pierre-Olivier Romero, Ignacio A Weksler, Babette Pombo, Celia M
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Published in
Biomedicines
Cerebral cavernous malformations (CCMs) are vascular malformations that can be the result of the deficiency of one of the CCM genes. Their only present treatment is surgical removal, which is not always possible, and an alternative pharmacological strategy to eliminate them is actively sought. We have studied the effect of the lack of one of the CC...
Santos, Stephany Richard, Kelsey Fisher, Melanie C Dealy, Caroline N Pierce, David M
Published in
Journal of the mechanical behavior of biomedical materials
We aimed to determine the longitudinal effects of low-energy (generally considered non-injurious) impact loading on (1) chondrocyte proliferation, (2) chondroprogenitor cell activity, and (3) EGFR signaling. In an in vitro study, we assessed 127 full-thickness, cylindrical osteochondral plugs of bovine cartilage undergoing either single, uniaxial u...
Verma, Saurav Vadlamani, Surya Prakash Shamim, Shamim Ahmed Barwad, Adarsh Rastogi, Sameer Raj, S. T. Arun
Published in
Clinical Sarcoma Research
BackgroundChordoma is a rare, slow growing and locally aggressive mesenchymal neoplasm with uncommon distant metastases. It is a chemo-resistant disease with surgery and radiotherapy being the mainstay in treatment of localized disease. In advanced disease imatinib has a role. We report a case of metastatic sacral chordoma with symptomatic and radi...
Jayathilake, Abilasha G. Veale, Margaret F. Luwor, Rodney Brain Nurgali, Kulmira Su, Xiao Q.
Published in
BMC Complementary Medicine and Therapies
BackgroundThe currently available treatments for colorectal cancer (CRC) are often associated with serious side-effects. Therefore, the development of a novel nutraceutical agent may provide an alternative complementary therapy for CRC. Overexpression of the epidermal growth factor receptor (EGFR) associates with a range of cancers while downregula...
Misiura, Magdalena Baszanowska, Weronika Ościłowska, Ilona Pałka, Jerzy Miltyk, Wojciech
Published in
International journal of molecular sciences
Recent reports have indicated prolidase (PEPD) as a ligand of the epidermal growth factor receptor (EGFR). Since this receptor is involved in the promotion of cell proliferation, growth, and migration, we aimed to investigate whether prolidase may participate in wound healing in vitro. All experiments were performed in prolidase-treated human kerat...
Le, Yi Gan, Yiyuan Fu, Yihong Liu, Jiamin Li, Wen Zou, Xue Zhou, Zhixu Wang, Zhenchao Ouyang, Guiping Yan, Longjia
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Published in
Journal of enzyme inhibition and medicinal chemistry
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results displayed that some of the compounds had good activit...