Hung, Wen-Yueh Chang, Jer-Hwa Cheng, Yu Chen, Chi-Kuan Chen, Ji-Qing Hua, Kuo-Tai Cheng, Chao-Wen Hsiao, Michael Chung, Chi-Li Lee, Wei-Jiunn
...
Published in
Cellular Physiology and Biochemistry
Background/Aims: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy is a clinical option for non-small cell lung cancer (NSCLC) harboring activating EGFR mutations or for cancer with wild-type (WT) EGFR when chemotherapy has failed. MET receptor activation or MET gene amplification was reported to be a major mechanism o...
Garbar, Christian Mascaux, Corinne Giustiniani, Jérôme Salesse, Stéphanie Debelle, Laurent Antonicelli, Frank Merrouche, Yacine Bensussan, Armand
Triple-negative breast carcinoma (TN) is a heterogeneous cancer type expressing EGFR in 75% of cases. MUC1 is a large type I sialylated glycoprotein comprising two subunits (α and β chains, also called respectively MUC1-VNTR and MUC1-CT), which was found to regulate EGFR activity through endocytic internalisation. Endocytosis and autophagy use the ...
Garbar, Christian Mascaux, Corinne Giustiniani, Jérôme Salesse, Stéphanie Debelle, Laurent Antonicelli, Frank Merrouche, Yacine Bensussan, Armand
Triple-negative breast carcinoma (TN) is a heterogeneous cancer type expressing EGFR in 75% of cases. MUC1 is a large type I sialylated glycoprotein comprising two subunits (α and β chains, also called respectively MUC1-VNTR and MUC1-CT), which was found to regulate EGFR activity through endocytic internalisation. Endocytosis and autophagy use the ...
Fu, Wenyan Sun, Hefen Zhao, Yang Chen, Mengting Yang, Lipeng Yang, Xueli Jin, Wei
Published in
Molecular immunology
The overexpression of EGFR often occurs in TNBC, and the anti-EGFR receptor antibody cetuximab is used widely to treat metastatic cancer in the clinic. However, EGFR-targeted therapies have been developed for TNBC without clinical success. In this study, we show that impaired EGFR degradation is crucial for resistance to cetuximab, which depends on...
Hetmanski, Joseph H R Schwartz, Jean-Marc Caswell, Patrick T
Published in
Small GTPases
Precise spatiotemporal dynamics of Rho GTPases are essential for efficient cell migration. Manipulating Rac1 and RhoA signaling is thus a potential intervention strategy to abrogate harmful cell invasion and subsequent metastasis; however GTPase signaling can be extremely complicated due to crosstalk and the multitude of upstream regulators and dow...
Cheng, Chao Deng, Li Li, Rongxiu
Published in
Cellular Physiology and Biochemistry
Background/Aims: The abnormally activated EGFR promotes tumor growth, invasion and metastasis. Current therapeutics targeting EGFR have markedly improved the clinical outcome, but they are limited in use due to transient efficacy, frequent administration, high cost and significant toxicity. Methods: We rationally designed a multiepitope immunogen a...
You, Hui Meng, Kun Wang, Zhao-Yi
Published in
Steroids
Hepatocellular carcinoma (HCC) is the common primary liver cancer and the third leading cause of cancer related mortality worldwide. It is generally thought that the estrogen-signaling pathway is not related to the development and progression of human HCC. However, accumulating evidences indicate the existence of a rapid estrogen signaling in HCC c...
Jebali, Ahlem Dumaz, Nicolas
AbstractThe importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been known for many years but the central role of RICTOR (rapamycin-insensitive companion of mTOR) in this pathway is only starting to emerge. RICTOR is critical for mTO...
Jebali, Ahlem Dumaz, Nicolas
AbstractThe importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been known for many years but the central role of RICTOR (rapamycin-insensitive companion of mTOR) in this pathway is only starting to emerge. RICTOR is critical for mTO...
Jebali, Ahlem Dumaz, Nicolas
AbstractThe importance of the network defined by phosphatidylinositol-3-kinase (PI3K), AKT and mammalian target of rapamycin (mTOR) downstream of Receptor Tyrosine Kinase (RTK) has been known for many years but the central role of RICTOR (rapamycin-insensitive companion of mTOR) in this pathway is only starting to emerge. RICTOR is critical for mTO...
