Classical Hodgkin’s Lymphoma in the Era of Immune Checkpoint Inhibition
PD-L1 inhibitor treatment, together with a part about angiogenesis, extracellular vesicles, and microbiome in HL pathogenesis.
Cancers in Humans: A Lifelong Search for Contributions of Infectious Agents, Autobiographic Notes
Published in Annual Review of Virology
This review briefly covers periods of my early life; experiences during World War II; my school education; and my period as a medical student in Bonn, Hamburg, and Düsseldorf. Mainly emphasized is my scientific career after finishing my medical internship and periods as a postdoc at the Institute for Microbiology in Düsseldorf and the Virus Laborat...
ABC of viral infections in hematology: focus on herpesviruses
Published in Acta Haematologica Polonica
Viruses are a form of life that possess genes but do not have a cellular structure. Viruses do not have their own metabolism, and they require a host cell to make new products; therefore, they cannot naturally reproduce outside a host cell. The objective of this paper is to present the basic practical clinical roles of viruses in patients with hema...
Two dose levels of rabbit antithymocyte globulin as graft-versus-host disease prophylaxis in haploidentical stem cell tr...
...Published in BMC Medicine
BackgroundThe optimal dose of rabbit antithymocyte globulin (ATG, ImtixSangstat) minimizing infections without increasing graft-versus-host disease (GVHD) is unknown in T cell-replete, G-CSF-primed haploidentical hematopoietic stem cell transplantation (haplo-HSCT).MethodsFour hundred and eight patients were enrolled in this multicenter study to ev...
Does the Walloon Piétrain pig breed require preservation measures?
Piétrain pigs are used worldwide as terminal sires, and they are not expected to require preservation measures. However, the number of pure Piétrain breeders is dwindling everywhere and also in Wallonia (southern Belgium), the region where the breed is originated from. As a first step, the objective of this study was to assess the genetic diversity...
Does the Epstein–Barr Virus Play a Role in the Pathogenesis of Graves’ Disease?
disease.
Epstein–Barr Virus and Innate Immunity: Friends or Foes?
B signaling and induces pro-inflammatory cytokines. Through differential modulation of the proviral and antiviral roles of caspases and other host factors at different stages of infection, EBV usurps cellular programs for death and inflammation to its own benefits. The outcome of EBV infection is governed by a delicate interplay between innate immu...
Conserved Features of the T Cell Receptor Repertoire Contribute to the Persistence of EBV-Specific CD8 T Cells
Epstein-Barr Virus (EBV) is a ubiquitous human virus linked to several diseases, including cancers. CD8 T cells are important for controlling EBV replication. Generation and maintenance of virus-specific CD8 T cells is dependent on specific interaction between MHC-peptide complexes on the infected cell and the CD8 T cell receptor (TCR). Several lin...
Detection of Epstein-Barr Virus Infection in Non-Small Cell Lung Cancer
...
Previous investigations proposed a link between the Epstein-Barr virus (EBV) and lung cancer (LC), but the results are highly controversial largely due to the insufficient sample size and the inherent limitation of the traditional viral screening methods such as PCR. Unlike PCR, current next-generation sequencing (NGS) utilizes an unbiased method f...
Early herpes and TTV DNAemia in septic shock patients: a pilot study
...Published in Intensive Care Medicine Experimental
BackgroundSeptic shock patients exhibit an increased incidence of viral reactivation. Precise timing of such reactivation—as an early marker of immune suppression, or as a consequence of the later—is not known precisely. Here, using a fully designed nucleic acid extraction automated procedure together with tailored commercial PCR kits, we focused o...
