Mbanefo, Evaristus C. Yan, Ming Kang, Minkyung Alhakeem, Sahar A. Jittayasothorn, Yingyos Yu, Cheng-Rong Parihar, Ashutosh Singh, Sunanda Egwuagu, Charles E.
Published in
Frontiers in Immunology
STAT3 activates transcription of genes that regulate cell growth, differentiation, and survival of mammalian cells. Genetic deletion of Stat3 in T cells has been shown to abrogate Th17 differentiation, suggesting that STAT3 is a potential therapeutic target for Th17-mediated diseases. However, a major impediment to therapeutic targeting of intracel...
sihan, wu rui, ma zhong, yajie chen, zilin zhou, hongyan zhou, minyi chong, waipo chen, jun
Human uveitis is an autoimmune disease of the central nervous system that is characterized by ocular inflammation with the involvement of uveitogenic Th1 and Th17 responses. In experimental autoimmune uveitis (EAU), the animal model for human uveitis, both responses are proven to be critical in disease development. Therefore, targeting both Th1 and...
Bradley, Lydia J. Ward, Amy Hsue, Madeleine C. Y. Liu, Jian Copland, David A. Dick, Andrew D. Nicholson, Lindsay B.
Published in
Frontiers in Immunology
Ocular inflammation imposes a high medical burden on patients and substantial costs on the health-care systems that mange these often chronic and debilitating diseases. Many clinical phenotypes are recognized and classifying the severity of inflammation in an eye with uveitis is an ongoing challenge. With the widespread application of optical coher...
Gasperi, Johnny TRAMOY, Romain Dris, Rachid Blot, Denis TASSIN, Bruno
Les rivières sont censées être les principales voies de transfert des plastiques des terres vers l'océan (Lebreton et al., 2017 ; Schmidt et al., 2017). Cependant, il existe encore un manque important de connaissances sur la façon dont les déchets fluviaux, y compris les macroplastiques, sont transférés vers l'Océan. Les mesures quantitatives des é...
LE VERN, Mickael sediki, ouardia RAZAKAMANANTSOA, Andry Murzyn, Frédéric LARRARTE, Frédérique INSENGA, Pascal Gotteland, Philippe
Dust emission is a major issue in general but even more for civil engineering professionals. This is particularly important on earthmoving sites with truck traffic on compacted soils. Suspended dust causes many troubles, including visibility mitigation, which leads to safety risks. To prevent the lift of particles, soils are watered abundantly. Whe...
Egwuagu, Charles E. Alhakeem, Sahar A. Mbanefo, Evaristus C.
Published in
Frontiers in Immunology
The profound impact that vision loss has on human activities and quality of life necessitates understanding the etiology of potentially blinding diseases and their clinical management. The unique anatomic features of the eye and its sequestration from peripheral immune system also provides a framework for studying other diseases in immune privilege...
SAILLIO, Mickael Sabeur, Hassen Vincent, Julien ZITOUN, Bruno
In case of fire in a structure, concrete undergoes internal transformations that can alter its durability. It is also important to take into account the effect of the cooling regime after temperature exposure on the phase assemblage of the cementitious matrix. An experimental investigation was carried out to investigate the changes of a cement past...
eskandarpour, malihe nunn, miles a. weston-davies, wynne calder, virginia l.
Retinal vascular diseases have distinct, complex and multifactorial pathogeneses yet share several key pathophysiological aspects including inflammation, vascular permeability and neovascularisation. In non-infectious posterior uveitis (NIU), retinal vasculitis involves vessel leakage leading to retinal enlargement, exudation, and macular oedema. N...
Hu, Jianping Yi, Shenglan Wang, Chaokui Zhang, Yiting Tang, Jihong Huang, Xinyue Yang, Lu Yang, Jinglu Li, Hong
Published in
Frontiers in Immunology
A20 is a negative regulator of inflammation and immunity and plays a role in several autoimmune and inflammatory diseases. Here, we demonstrate that A20 overexpression significantly ameliorates severity of EAU by inhibiting the infiltration of Th1 and Th17 cells, and by protecting integrity of the blood retinal barrier. In vitro studies showed that...
Li, Pengfei FENG, Chunhui LIU, Hongchuan ZHAOC, Yong Li, Zhen XIONG, Haocheng
To efficiently reduce the secondary lining external water pressure on underwater tunnels, the feasibility of a novel bottom-up drainage and water pressure reduction system for reducing has been validated by conducting laboratory evaluations. Critical factors of underwater tunnels, including the surrounding environment, lining, bottom drainage syste...
