Published in Frontiers in Ophthalmology
Background Recent studies reported a link between high salt diet (HSD) and clinical exacerbation in mouse models of autoimmune diseases, mainly through the induction of pathogenic Th17 cells and/or HSD-induced dysbiosis. However, the topic remains controversial and not fully understood. Purpose In this study, we investigated the effects of HSD on t...
Published in International immunopharmacology
Extensive research has revealed the favorable effects of celastrol (CEL) against various diseases, but the role of CEL in autoimmune uveitis remains unexplored. We first assessed the prophylactical and therapeutical effects of CEL on autoimmune uveitis via rat experimental autoimmune uveitis model. After network pharmacology, functional enrichment ...
Published in International immunopharmacology
Purinergic ligand-gated ion channel 7 receptor (P2X7R) is a purine type P2 receptor that is expressed on a variety of immune cells. Recent studies have shown that P2X7R signaling is required to trigger an immune response, and P2X7R antagonist-oxidized ATP (oxATP) effectively blocks P2X7R activation. In this study, we investigated the effect of phas...
Published in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
There is no consensus concerning the appropriate use of androgen deprivation therapy (ADT) during primary and postoperative external-beam radiotherapy (EBRT) in the management of prostate cancer (PCa). Thus, the European Society for Radiotherapy and Oncology (ESTRO) Advisory Committee for Radiation Oncology Practice (ACROP) guidelines seeks to pres...
L’Arabie saoudite et les Émirats arabes unis ont fait évoluer leur politique étrangère en cherchant une autonomie accrue répondant aux priorités de leurs intérêts nationaux. La recherche de multi-partenariats plus équilibrés est en cours tant avec la Russie et la Chine, obligeant les États-Unis et l’UE à mieux prendre en compte les besoins des pays...
Biochar aging may affect the interactions of biochar with water and thus its performance as soil amendment; yet the specific mechanisms underlying these effects are poorly understood. By means of FTIR, N2 adsorption, Hg intrusion porosimetry, thermogravimetric analysis, 13C solid state nuclear magnetic resonance (NMR) and 1H NMR relaxometry, we inv...
35ème colloque de l'Association Internationale de Climatologie - AIC 2022, TOULOUSE, FRANCE, 06-/07/2022 - 09/07/2022
Published in Frontiers in Immunology
Background Behcet’s disease (BD) is a chronic immune disease that involves multiple systems. As the pathogenesis of BD is not clear, and new treatments are needed, we used bioinformatics to identify potential drugs and validated them in mouse models. Methods Behcet’s disease-related target genes and proteins were screened in the PubMed and UVEOGENE...
Although runoff from trafficked urban areas is recognized as a potentially significant pathway of micropollutants, runoff pollution remains poorly documented, except for relatively few historical pollutants such as some metals and hydrocarbons. Therefore, in this work, road and parking lot runoff from four sites with contrasting traffic levels were...
Published in Frontiers in Immunology
Experimental autoimmune uveitis (EAU), a model of human uveitis, is an organ-specific, T cell-mediated autoimmune disease. Autoreactive T cells can penetrate the blood-retinal barrier, which is a physical defense composed of tight junction-linked retinal pigment epithelial (RPE) cells. RPE cells serve as antigen-presenting cells (APCs) in the eye s...
