Raj, Resal
Published in
Biochemistry and biophysics reports
The ORF1ab of Severe Acute Respiratory Syndrome, SARS Corona Virus, SARS-CoV-2 genome is processed into 15 non-structural proteins, NSPs by proteases and each NSP has a specific role in the life cycle and pathogenicity of the virus. This research analyzes possible drugs for these proteins as targets in computational drug designing using already ava...
Ben Nessib, Dorra Maatallah, Kaouther Ferjani, Hanene Kaffel, Dhia Hamdi, Wafa
Published in
Clinical rheumatology
Ramadan, the ninth month of the Muslim lunar calendar, is a period of intermittent fasting alternated with moments of refeeding. The last decades have seen a growing number of reports that examine the potential effect of Ramadan intermittent fasting (RIF) on chronic musculoskeletal disorders. In this paper, we reviewed data that assessed the relati...
Gill, Dipender Georgakis, Marios K. Walker, Venexia M. Schmidt, A. Floriaan Gkatzionis, Apostolos Freitag, Daniel F. Finan, Chris Hingorani, Aroon D. Howson, Joanna M.M. Burgess, Stephen
...
Published in
Wellcome Open Research
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that encode drug targets can be used in Mendelian randomization analyses to offer insight into mechanism-based efficacy and adverse e...
Fuertes, Ricardo Belo, Elsa Merendeiro, Cristiana Curado, Adriana Gautier, Diana Neto, Ana Taylor, Hannah
Published in
Harm Reduction Journal
Four emergency shelters were instituted in Lisbon during COVID-19, and are still in operation. Between March and August 2020, they served over 600 people. The shelters host a diverse population, including people experiencing homelessness, foreigners, LGBTI + people, those with reduced mobility, couples, those with pets, and People Who Use Drugs, in...
Kaul, Laurine Süss, Regine Zannettino, Andrew Richter, Katharina
Published in
iScience
Drugs; Microbiology
Roberson, Zackery R Goodpaster, John V
Published in
Talanta
Gas Chromatography-Vacuum UV Spectroscopy (GC-VUV) has seen increased attention in many areas, however, a statistical optimization of VUV method parameters has not been published. This article presents the first statistical optimization of parameters influencing analytes such as cocaine in the VUV flow-cell. Flow-cell temperature, make-up gas press...
Hashemzaei, Mahmoud Afshari, Mahdi Koohkan, Zahra Bazi, Ali Rezaee, Ramin Tabrizian, Kaveh
Published in
BMC Medical Education
BackgroundSelf-medication is defined as using medicinal products to treat the disorders or symptoms diagnosed by oneself. Although informed self-medication is one of the ways to reduce health care costs, inappropriate self-treatment can pose various risks including drug side effects, recurrence of symptoms, drug resistance, etc. The purpose of this...
LEITE, C. R. ASCOLI, F. O. OLIVEIRA, J. de FERNANDES, D. A. de M. FONSECA, J. F. da BRANDÃO, F. Z.
Abstract: This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2....
Swalve, N. DeFoster, R. Konoplyanko, Maksim
Published in
SN Social Sciences
Perceptions of illicit drugs may relate to factors such as media coverage and demographic variables, yet little is known about the relative importance of these factors, even though perceptions of harm are strongly associated with increased use. This study explores young adults’ beliefs about illicit drugs and investigates several variables that may...
Zhang, Jiuping Cheng, Xin Zhang, Huihui Xu, Ping Jin, Peiying Ke, Xiaoyan
Published in
BMC Psychiatry
BackgroundThere is limited evidence on the use of antipsychotics in patients with early-onset schizophrenia, which lags significantly behind the studies on adult patients’ medication and has a large disparity from actual clinical needs. Hence, this study aims to analyse the status of the drug use and its changes for patients with early-onset schizo...
