Bonnard, Benjamin Martínez-Martínez, Ernesto Fernández-Celis, Amaya Pieronne-Deperrois, Marie Do, Quoc-Tuan Ramos, Isbaal Rossignol, Patrick Zannad, Faiez Mulder, Paul Ouvrard-Pascaud, Antoine
...
Published in
Scientific Reports
Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences of cardiovascular and renal damage. We aimed to design chemical NGAL inhibitors and investigate its effects in experimental models of myocardial infarction (MI) and chronic kidney d...
Li, Xin Song, Yongcheng
Published in
Journal of Hematology & Oncology
Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a master regulator for transcription of important genes (e.g., Hox genes) for embryonic development and hematopoiesis. However, it is largely dispensable in matured cells. Dysregulation of MLL1 lea...
Kwon, Diana
Published in
Nature
A class of drugs that silence the effects of faulty genes could help tackle brain diseases — but a halted clinical trial has brought the field up short.
Rahman, Atikur Susmi, Tasmina Ferdous Yasmin, Farzana Bhattacharjee, Arittra Hossain, Mohammad Uzzal Das, Keshob Chandra Keya, Chaman Ara Salimullah, Md.
Published in
Network Modeling Analysis in Health Informatics and Bioinformatics
Dengue fever is the most widespread mosquito-borne viral disease caused by the four serotypes of Dengue virus that belong to the Genus Flavivirus (family Flaviviridae). The diversity of serotype makes the diseases fatal with the possibility to be infected four times and makes complications in the antiviral drug discovery process. In this study, we ...
Tielker, Nicolas Eberlein, Lukas Hessler, Gerhard Schmidt, K Friedemann Güssregen, Stefan Kast, Stefan M
Published in
Journal of computer-aided molecular design
Joint academic-industrial projects supporting drug discovery are frequently pursued to deploy and benchmark cutting-edge methodical developments from academia in a real-world industrial environment at different scales. The dimensionality of tasks ranges from small molecule physicochemical property assessment over protein-ligand interaction up to st...
Morawietz, Tobias Artrith, Nongnuch
Published in
Journal of computer-aided molecular design
Atomistic simulations have become an invaluable tool for industrial applications ranging from the optimization of protein-ligand interactions for drug discovery to the design of new materials for energy applications. Here we review recent advances in the use of machine learning (ML) methods for accelerated simulations based on a quantum mechanical ...
Bhatt, Lokesh Kumar Selokar, Ishant Raut, Dezaree Hussain, Tahir
Published in
Current Hypertension Reports
Purpose of ReviewDespite the availability of various medications and prescribing combination therapies, uncontrolled blood pressure and resistance are observed in more than 40% of patients. The purpose of this review is to discuss emerging novel approaches for the treatment of hypertension and propose future research and clinical directions.Recent ...
Pulla, Priyanka
Published in
Nature
Funding for translational research is boosted under joint initiatives to develop indigenous vaccines.
Song, Lan-Gui Xie, Qing-Xing Lao, Hui-Lin Lv, Zhi-Yue
Published in
Infectious Diseases of Poverty
BackgroundCoronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs). Although HCoV-specific drugs are still lacking, many potent targets for drug discovery are being explored, and many vigorously designed clinical trials are being carried out in an orderly manner....
Tiberi, Simon Vjecha, Michael J. Zumla, Adam Galvin, Jessica Migliori, Giovanni Battista Zumla, Alimuddin
Published in
International Journal of Infectious Diseases
The WHO 2020 global TB Report estimates that in 2019 there were an estimated 500,000 cases of multi-drug resistant TB (MDR-TB) of which only 186,772 MDR-TB cases were diagnosed, and positive treatment outcomes were achieved in 57% of them. These data highlight the need for accelerating and improving MDR-TB screening, diagnostic, treatment and patie...
