Zhu, Anran Jiang, Yingyu Pan, Longxiang Li, Jiale Huang, Yao Shi, Minghui Di, Liuqing Wang, Lei Wang, Ruoning
Published in
Journal of controlled release : official journal of the Controlled Release Society
Ischemic stroke (IS), accounting for 87 % of stroke incidences, constitutes a paramount health challenge owing to neurological impairments and irreversible tissue damage arising from cerebral ischemia. Chief among therapeutic obstacles are the restrictive penetration of the blood-brain barrier (BBB) and insufficient targeting precision, hindering t...
Taille, Thibault de La Sarfati, Pierre Aid, Rachida Fournier, Louise Pavon-Djavid, Graciela Chaubet, Frédéric Chauvierre, Cédric
Among cardiovascular diseases, thrombotic diseases such as ischemic heart disease and acute ischemic strokes are the most lethal, responsible by themselves for a quarter of worldwide deaths. While surgical treatments exist, they may not be used in all situations and systemic thrombolytic drug injection, such as recombinant tissue plasminogen activa...
a., hosseini s. baino, f. -w., kim h.
Carbon-based nanostructures have attracted significant attention over the past decades due to their unique physical properties, versatile functionalization chemistry, and biological compatibility. These nanomaterials can be categorized into graphene derivatives, fullerenes, nanotubes, nanodiamonds, and nanodots based on their morphologies. The uniq...
Fu, Qiuxia Liu, Yangjie Peng, Cao Muluh, Tobias Achu Anayyat, Umer Liang, Liu
Published in
Current drug delivery
Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants, intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic medicines have serious adverse effects, necessitating the develo...
kermani, f. gorgani, s. mollazadeh, s. baino, f. kargozar, s.
Hydroxyapatite (HAp) nanoparticles have recently achieved a unique position in cancer diagnosis and therapy (theranostics). In vitro experiments have shown that HAp nanoparticles can enter tumor cells and cause programmed cell death (apoptosis). To improve the anticancer effects of HAp nanoparticles, bioengineers and biomedical scientists incorpora...
nazarnezhad, s. gorgani, s. a., hosseini s. azari, z. baino, f.
Despite prominent progress in cancer detection and therapy, critical challenges still remain and need to be addressed. In this sense, several innovative biomaterials have been designed and produced using different types of biocompatible materials like metals, and polymers, as well as glasses and glass-ceramics. Currently, more precise treatments ca...
Wang, Jianjun Zhang, Tao Jiang, Yingqi Han, Wei Huang, Shimeng Zhao, Jihong Du, Xiru
Published in
Materials Science-Poland
Spinal cord injuries (SCIs) continue to pose a significant challenge in regenerative medicine and neuroscience, inflicting severe consequences on affected individuals. This study aims to evaluate the therapeutic efficacy of sports medicine along with gelatin electrospun scaffolds loaded with green tea extract (GTE) and seeded with bone marrow-deriv...
Dauba, Ambre Spitzlei, Claire Jourdain, Laurène Selingue, Erwan Denis, Caroline Ouldali, Malika Arteni, Ana-Andreea Truillet, Charles Larrat, Benoit Tsuruta, James
...
Low-boiling point perfluorocarbon nanodroplets (NDs) are valued as effective sonosensitive agents, encapsulating a liquid perfluorocarbon that would instantaneously vaporize at body temperature without the NDs shell. Those NDs have been explored for both therapeutic and diagnostic purposes. Here, phospholipid-shelled nanodroplets containing octaflu...
Eickner, Thomas Huling, Jennifer Oschatz, Stefan Lange, Helge Peil, Anita Undre, Nasrullah Stachs, Oliver Stahnke, Thomas Grabow, Niels Jünemann, Anselm
...
Published in
Current Directions in Biomedical Engineering
Antifibrotic treatment during glaucoma surgery leads to an improved outcome for patients. Drug delivery systems for placement under the subconjuctiva after surgery made of cyclodextrins and crosslinked with Epichlorohydin were loaded with Josamycin and tested in vivo. After subconjunctival application in three New Zealand White rabbits, blood sampl...
Chakraborty, Chiranjib Bhattacharya, Manojit Lee, Sang-Soo
Published in
Molecular biotechnology
In recent years, microneedle (MN) patches have emerged as an alternative technology for transdermal delivery of various drugs, therapeutics proteins, and vaccines. Therefore, there is an urgent need to understand the status of MN-based therapeutics. The article aims to illustrate the current status of microneedle array technology for therapeutic de...
