Danneels, Pierre Hamel, Jean-François Picard, Léa Rezig, Schéhérazade Martinet, Pauline Lorleac'h, Aurélien Talarmin, Jean-Philippe Buzelé, Rodolphe Guimard, Thomas Le Moal, Gwenaël
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Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other infective endocarditis. The role of the treatment on its occurrence remains poorly understood. The aim of this study was to investigate whether the antibiotic regimen could impact the risk of relapse in EFIE. This was a multicenter retr...
Verdezoto Unda, Stella Damaris Estrella, Bertha Robles Aguirre, Renato Samuel
Acute lymphoblastic leukemia is the most common childhood neoplasia. Current treatments allow more than 80% disease-free survival for five years. In 2000, a chemotherapy protocol called Berlin-Frankfurt-Münster intercontinental lymphoblastic leukemia (ALLIC BFM) was tested. The investigative process was carried out using the PRISMA methodology. Thi...
Lozada Martinez, Iván David Domínguez Alvarado, Gonzalo Andrés Torres Pérez, Fernando Johanna Cruz Rodríguez, Leidy Gamboa Perdomo, María Camila Reales Hernández, Karen Elena Hurtado Quiros, Luisa Fernanda Alirio Galindo Ruiz, Lesmer
Asthma is a chronic inflammatory disease of the respiratory tract which causes high health costs, substantially affects the quality of life and, depending on certain associated risk factors, reduces the functional capacity of the sufferer. By 2019, asthma affected 262 million people (4.3 % of the world’s population) and caused 461,000 deaths. It is...
Zhang, Ziyang Fan, Qiwen Luo, Xujun Lou, Kevin Weiss, William A Shokat, Kevan M
On-target-off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates1,2. In diseases of the central nervous system, drugs with brain-restricted pharmacology are highly desirable. Here we report a strategy to achieve inhibition of mammalian target of rapamycin (mTOR) while sparing m...
Ravi, Karthik Meng, George Roberts, Holly J Schepers, Allison Franson, Andrea Koschmann, Carl Marini, Bernard L Flynn, Allen
Published in
Studies in health technology and informatics
This paper offers a case study to demonstrate how a complex scoring model tool called CNS-TAP, originally created by a neuro-oncology team at one institution, was upgraded and made accessible to a wider audience. In the Results and Discussion, many issues of web app design, development, and sustainability are covered. Overall, we chart a path to ex...
Tawbi, Hussein A Robert, Caroline Brase, Jan C Gusenleitner, Daniel Gasal, Eduard Garrett, James Savchenko, Alexander Görgün, Güllü Flaherty, Keith T Ribas, Antoni
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BackgroundThe randomized phase 3 COMBI-i trial did not meet its primary endpoint of improved progression-free survival (PFS) with spartalizumab plus dabrafenib and trametinib (sparta-DabTram) vs placebo plus dabrafenib and trametinib (placebo-DabTram) in the overall population of patients with unresectable/metastatic BRAF V600-mutant melanoma. This...
Mathad, Jyoti S Savic, Rada Britto, Paula Jayachandran, Priya Wiesner, Lubbe Montepiedra, Grace Norman, Jennifer Zhang, Nan Townley, Ellen Chakhtoura, Nahida
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BackgroundPregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis prevention in adults and children, including those with HIV, but 3HP has not been evaluated in pregnancy.MethodsIMPAACT 2001 was a phase I/II trial evaluating the pharmacoki...
Villain, Nicolas
Research on disease-modifying treatments for Alzheimer's disease has resulted in a series of failures over the past 20 years. However, in the last three years, four molecules have shown significant effects on clinical endpoints in phase II or III clinical trials (i.e., slowing of cognitive decline). Among these four molecules, 3 are anti-amyloid im...
Bezu, Lucillia Chuang, Alejandra Wu Sauvat, Allan Humeau, Juliette Xie, Wei Cerrato, Giulia Liu, Peng Zhao, Liwei Zhang, Shuai Le Naour, Julie
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Background: Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery. Here, we investigated the anticancer effects of six local anesthetics used in clinical practice. Results: In vitro, local anesthetics induced signs of cancer cell stress in...
Sadigursky, David Magnavita, Victor Filardi Stolze Sá, Cloud Kennedy Couto DE Monteiro, Henrique DE Sousa Braghiroli, Oddone Freitas Melro Matos, Marcos Antônio Almeida
Published in
Acta ortopedica brasileira
Dor, rigidez articular e qualidade de vida (domínio físico) melhoram com a inclusão do UC-II por 90 dias ao arsenal terapêutico na OA do joelho em indivíduos de 60 a 80 anos. Nível de Evidência II, Estudo Prospectivo Comparativo.
