Published in Expert review of vaccines
Infectious disease emergencies like the 2013-2016 Ebola epidemic and the 2009 influenza and current SARS-CoV-2 pandemics illustrate that vaccines are now given to diverse populations with preexisting pathologies requiring pharmacological management. Many natural biomolecules (steroid hormones, fatty acids, vitamins) and ~60% of prescribed medicatio...
Published in Drug metabolism reviews
The 12th International Society for the Study of Xenobiotics (ISSX) meeting, held in Portland, OR, USA from July 28 to 31, 2019, was attended by diverse members of the pharmaceutical sciences community. The ISSX New Investigators Group provides learning and professional growth opportunities for student and early career members of ISSX. To share meet...
Published in Journal of Crohn's & colitis
The gut microbiota plays an important role in the metabolization and modulation of several types of drugs. With this study we aimed to review the literature about microbial drug metabolism of medication prescribed in inflammatory bowel disease practice. A systematic literature search was performed in Embase and PubMed from inception to October 2019...
Published in Expert opinion on drug metabolism & toxicology
Introduction: There is considerable variability in the rates and extent of drug metabolism between patients due to physiological, genetic, pharmacologic, environmental and nutritional factors such as fasting. This variability in drug metabolism may result in treatment failure or, conversely, in increased side effects or toxicity. Preclinical studie...
The use of metal-based drugs is increasingly gaining importance in medicine and renownedconferences such as the International Symposium on Bioorganometallic Chemistry (ISBOMC)are excellent opportunities for scientists in the field to exchange ideas and present theirresearch on this topic. We decided to dedicate one of our group’s presentations at I...
Published in Current pharmaceutical design
Drug hypersensitivity reactions (DHRs) represent a major burden on the healthcare system since their diagnostic and management are complex. As they can be influenced by individual genetic background, it is conceivable that the identification of variants in genes potentially involved could be used in genetic testing for the prevention of adverse eff...
Published in EPRA International Journal of Multidisciplinary Research (IJMR)
Drug discovery and development involve the utilization of in vitro and in vivo experimental models. Different models, ranging from test-tube experiments to cell cultures, animals, healthy human subjects, and even small numbers of patients that are involved in clinical trials, are used at different stages of drug discovery and development for determ...
Drugs and other xenobiotic compounds exhibit different transformations upon entering the human body, most often starting with an oxidative reaction involving P450 enzymes. Hence, the effectiveness and half-life, and even the toxicity of these drugs is determined in part to their metabolism. Thus, it is imperative to produce better models, either ex...
AIM: The aim of this study was to study potential cytochrome P450 (CYP) induction by dicloxacillin. METHODS: We performed an open‐label, randomized, two‐phase, five‐drug clinical pharmacokinetic cocktail crossover study in 12 healthy men with and without pretreatment with 1 g dicloxacillin three times daily for 10 days. Plasma and urine were collec...
Published in Journal of clinical pharmacology
The objective of this study was to evaluate the predictive performances of allometric models and a physiologically based pharmacokinetic model (PBPK) to predict clearance of glucuronidated drugs in neonates (≤ 3 months of age). From the literature, clearance values for 9 drugs (glucuronidated) for neonates and adults were obtained. Three allometric...
