Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
...
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
...
The discovery and development of inhaled therapeutics for migraine
Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents
Screening drugs for myocardial disease in vivo with zebrafish: an expert update
Screening drugs for myocardial disease in vivo with zebrafish: an expert update
Screening drugs for myocardial disease in vivo with zebrafish: an expert update
The use of mechanistic evidence in drug approval.
AHRC grant number AH/M005917/1 Leverhulme Trust grant number RPG-2014-181
The use of mechanistic evidence in drug approval.
AHRC grant number AH/M005917/1 Leverhulme Trust grant number RPG-2014-181
Decompositions of Free Energies in Molecular Simulation
This thesis describes advances in methods to measure free energy changes in simulations of molecular systems. In each case the free energy is decomposed into local environments which reveal insights about the complex systems being studied. Free energy is a fundamental quantity that can be used to predict whether changes in state are physically favo...
