Tabuloc, Christine Carlson, Curtis Ganjisaffar, Fatemeh Truong, Cindy Chen, Ching-Hsuan Lewald, Kyle Hidalgo, Sergio Nicola, Nicole Jones, Cera Sial, Ashfaq
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Drosophila suzukii lay eggs in soft-skinned, ripening fruits, making this insect a serious threat to berry production. Since its 2008 introduction into North America, growers have used insecticides, such as pyrethroids and spinosads, as the primary approach for D. suzukii management, resulting in development of insecticide resistance in this pest. ...
Kalantar-Zadeh, Kamyar Ficociello, Linda Zhou, Meijiao Anger, Michael
BACKGROUND: Hyperphosphatemia is associated with increased morbidity and mortality in patients with end-stage kidney disease (ESKD). Whereas clinical and observational studies have demonstrated the effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus (sP) in ESKD, data on the real-world impact of switching to SO in patient...
Dayyani, Farshid Balangue, Jasmine Valerin, Jennifer Keating, Matthew J Zell, Jason A Taylor, Thomas H Cho, May T
IntroductionThis study determined the safety and recommended phase 2 dose (RP2D) of the multikinase inhibitor cabozantinib in combination with trifluridine/tipiracil (FTD/TPI) in refractory metastatic colorectal carcinoma (mCRC).Patients and methodsSingle institution investigator-initiated phase 1 study using 3+3 design. Eligible mCRC patients had ...
Roh, Michelle Zongo, Issaka Haro, Alassane Huang, Liusheng Somé, Anyirékun Yerbanga, Rakiswendé Conrad, Melissa Wallender, Erika Legac, Jennifer Aweeka, Francesca
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BACKGROUND: Despite scale-up of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine (SP-AQ) in children 3-59 months of age in Burkina Faso, malaria incidence remains high, raising concerns regarding SMC effectiveness and selection of drug resistance. Using a case-control design, we determined associations between S...
Cho, Minhee Oh, Eunsook Ahn, Byungjin Yoon, MoonTae
Published in
Translational and clinical pharmacology
While previous studies have examined the dose-response characteristics of certain antihypertensive drugs alone or in combination, response surface analysis for combination therapies involving angiotensin receptor blockers (ARBs) and either amlodipine (AML) or hydrochlorothiazide (HCT) has not been explored, particularly in the context of low-dose c...
Zhang, Haoting Ek, Carl Henrik Rattray, Magnus Milo, Marta
Funder: Wellcome Cambridge Trust Scholarship / Funder: Health Data Research UK / MOTIVATION: There exists a range of different quantification frameworks to estimate the synergistic effect of drug combinations. The diversity and disagreement in estimates make it challenging to determine which combinations from a large drug screening should be procee...
Zhang, Haoting Ek, Carl Henrik Rattray, Magnus Milo, Marta
Acknowledgements: The authors thank Mateja Jamnik, Pietro Liò, Krishna Bulusu, Paul Metcalfe, and Elizaveta Semenova for their valuable comments and suggestions. This work was performed using resources provided by the CSD3 operated by the University of Cambridge Research Computing Service. / Funder: Health Data Research UK; DOI: https://doi.org/10....
Gross, Sean M Mohammadi, Farnaz Sanchez-Aguila, Crystal Zhan, Paulina J Liby, Tiera A Dane, Mark A Meyer, Aaron S Heiser, Laura M
Identifying effective therapeutic treatment strategies is a major challenge to improving outcomes for patients with breast cancer. To gain a comprehensive understanding of how clinically relevant anti-cancer agents modulate cell cycle progression, here we use genetically engineered breast cancer cell lines to track drug-induced changes in cell numb...
Du, Zhanwei Wang, Lin Bai, Yuan Liu, Yunhu Lau, Eric HY Galvani, Alison P Krug, Robert M Cowling, Benjamin John Meyers, Lauren A
Peer reviewed: True / Acknowledgements: Individual patient-informed consent was not required in this study using anonymized data. Financial support was provided by the AIR@InnoHK Programme from Innovation and Technology Commission of the Government of the Hong Kong Special Administrative Region, Health and Medical Research Fund Research Fellowship ...
Prager, Gerald W.; Taieb, Julien; Fakih, Marwan; Ciardiello, Fortunato; Van Cutsem, Eric; Elez, Elena; Cruz, Felipe M.; Wyrwicz, Lucjan; Stroyakovskiy, Daniil; Papai, Zsuzsanna;
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BACKGROUND: In a previous phase 3 trial, treatment with trifluridine-tipiracil (FTD-TPI) prolonged overall survival among patients with metastatic colorectal cancer. Preliminary data from single-group and randomized phase 2 trials suggest that treatment with FTD-TPI in addition to bevacizumab has the potential to extend survival. METHODS: We random...