Published in Dysphagia
Sialorrhoea in Parkinson's disease (PD) is an often neglected yet key non-motor symptom with impact on patient quality of life. However, previous studies have shown a broad range of prevalence figures. To assess prevalence of drooling in PD and its relationship to quality of life, we performed a retrospective analysis of 728 consecutive PD patients...
Published in BMC Pediatrics
BackgroundDrooling is common in children with neurological disorders, but its management is very challenging, Scopolamine transdermal patch (STP) appears to be useful in controlling drooling, although it is not approved for this indication and there are limited clinical studies about its effectiveness. This study aimed (1) to assess the impact of S...
Published in Chinese Journal of Contemporary Pediatrics
目的 观察咀嚼功能训练（FuCT）对脑瘫儿童咀嚼功能、舌尖推力严重程度、流涎严重程度及流涎频率的影响。 方法 前瞻性选择2019年1月至2020年1月诊断为口腔运动功能障碍的脑瘫儿童48例为研究对象，随机分为FuCT组（ n =24）和口腔运动训练组（ n =24）。每组均接受12周训练，评估两组儿童咀嚼功能、舌尖推力严重程度、流涎严重程度和流涎频率的变化情况。 结果 两组儿童训练前咀嚼功能、舌尖推力严重程度、流涎严重程度及流涎频率比较差异无统计学意义（ P > 0.05）。训练12周后，FuCT组咀嚼功能、舌尖推力严重程度、流涎严重程度均有改善（ P 0.05）；口腔运动训练组咀嚼功能、舌尖推力严重程度、流涎严重程度及流涎频率均无明显改善（ P > 0.05）。训练12周后，FuCT组舌...
Published in Clinical neurology and neurosurgery
The aim of the present study was to determine the relationships of drooling with motor symptoms and nigrostriatal neuron loss in drug-naïve patients with Parkinson's disease (PD). We therefore examined the relationships of drooling with motor symptoms and striatal dopamine transporter (DAT) binding measured by [123-Iodine]-fluoropropyl-2beta-carbom...
Published in Journal of Neurology
Background Drooling is dependent on various clinical variables. However, while drooling proves refractory to two-duct ligation in 40% of patients, predictors for treatment success are sparse and to date there is little evidence why some respond well while others are non-responders. We aim to find predictors for treatment success and study the effec...
Published in Clinics in geriatric medicine
This article reviews the most common gastrointestinal (GI) problems that occur in patients with Parkinson disease, including weight loss, drooling, dysphagia, delayed gastric emptying, constipation, and defecatory dysfunction. Appropriate workup and treatment options are reviewed in detail in order to provide clinicians with a comprehensive and pra...
Published in Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Drooling is a common symptom of neurodegenerative diseases. We aimed to explore the frequency of drooling and its relationship to clinical features in a relatively large cohort of Chinese patients with multiple system atrophy (MSA). We conducted a cross-sectional survey of 143 patients with MSA. Patients with drooling were identified as those with ...
Published in Neurology and therapy
Botulinum neurotoxin (BoNT) is considered the treatment of choice for various symptoms and diseases such as focal dystonia and focal spasticity. The effects of BoNT on the salivary glands have also been known for years, but their use was limited because of a lack of approval studies. Now the indication of sialorrhea is approved in some countries fo...
Published in Journal of neural transmission (Vienna, Austria : 1996)
Hypersalivation describes a relatively excessive salivary flow, which wets the patient himself and his surroundings. It may result because of insufficient oro-motor function, dysphagia, decreased central control and coordination. This update presents recent changes and innovation in the treatment of hypersalivation. Multidisciplinary diagnostic and...
Published in Pilot and Feasibility Studies
BackgroundClozapine-induced hypersalivation (CIH) is a common side effect of clozapine treatment and is disliked by clozapine patients, potentially threatening adherence to clozapine treatment. We proposed a trial of alternative medications, hyoscine and glycopyrrolate, for the treatment of CIH and the primary objective of the feasibility study was...
