Isa, Mustafa Alhaji Mohammed, Mohammed Mustapha
Published in
Network Modeling Analysis in Health Informatics and Bioinformatics
The UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) catalyzes the final steps of the UDP-N-acetylmuramic acid (UDPMurNAc) formation in the peptidoglycan biosynthesis pathway. The absence of this pathway in mammals made it an attractive target for drug development in Mycobacterium tuberculosis (MTB). In this study, the crystal structure of MurB...
dos Santos, Elias Silva de Azevedo Santos Ferreira, Joalene dos Santos, Jacson Nunes Chinalia, Fábio Alexandre Matos, Josilene Lima Coqueiro, Gustavo Ramos-de-Souza, Elias de Almeida, Paulo Fernando
Published in
Journal of Molecular Modeling
Sulphate-reducing bacteria are commonly associated with biological causes of oil well souring. Biosulphetogenesis can directly affect oil quality and storage due to the accumulation of sulphides. In addition, these microorganisms can create bio-incrustation that can clog pipes. Sulphite reductase (SIR) is the enzyme responsible for converting ion s...
Mureed, Shumaila Naz, Sadia Haider, Ali Raza, Ali Ul-Hamid, Anwar Haider, Junaid Ikram, Muhammad Ghaffar, Rabia Irshad, Muneeb Ghaffar, Abdul
...
Published in
Nanoscale Research Letters
The present study is concerned with evaluating the influence of various concentrations of Ag within Cu:Ag bimetallic nanoparticles developed for use as a promising anti-bacterial agent against antibiotic-resistant bacteria. Here, Cu:Ag bimetallic nanoparticles with various concentration ratios (2.5, 5.0, 7.5, and 10 wt%) of Ag in fixed amount of Cu...
Rani, Shradha Kumari, Priya Poddar, Raju Chattopadhyay, Soham
Published in
Journal of Genetic Engineering and Biotechnology
BackgroundLipases (EC 3.1.1.3) catalyze the hydrolysis of oil into free fatty acids and glycerol forming the 3rd largest group of commercialized enzymes. Plant lipases grab attention recently because of their specificity, less production and purified cost, and easy availability. In silico approach is the first step to identify different genes codin...
Shoman, Mai E Aboelez, Moustafa O Shaykhon, Montaser Sh A Ahmed, Sanaa A Abuo-Rahma, Gamal El-Din A Elhady, Omar M
Published in
Molecular diversity
Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a-h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14-19% compared to control group....
Bahmani, Asrin Tanzadehpanah, Hamid Hosseinpour Moghadam, Neda Saidijam, Massoud
Published in
Molecular diversity
In cancer disease, which is one of the problems of today's human societies, the expression of some tyrosine kinase receptors that are effective in the growth and proliferation of cancerous cells rises. Therefore, it is essential to develop and propose new drugs to target the receptors. Performing modeling calculations such as QSAR and docking makes...
Ullah, Md. Asad Johora, Fatema Tuz Sarkar, Bishajit Araf, Yusha Ahmed, Nafisa Nahar, Abida Nurun Akter, Tanzina
Published in
Egyptian Journal of Medical Human Genetics
BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative age-related dementia that results in memory loss of elderly people. Many hypotheses have been formally articulated till now to decipher the pathogenesis of this disease. According to the compelling amyloidogenic hypothesis, β-secretase is a key regulatory enzyme in AD development...
Lenfant, Louis Kim, Soodong Aminsharifi, Alireza Sawczyn, Guilherme Kaouk, Jihad
Published in
World journal of urology
To compare the range of motion and ergonomic characteristics of single-port robotic instruments in the setting of the "floating" versus "flat" docking technique using the GelPOINT® system. The basic principle of the floating docking technique resides in the GelSeal cap and trocar (s) being 8 cm off the skin level with the Alexis® acting as a condui...
Pacureanu, Liliana Avram, Sorin Crisan, Luminita
Published in
Journal of biomolecular structure & dynamics
Interaction signatures of drug candidates are characteristic to off-target (neutral) and antitarget (negative) effects, inferring reduced efficiency, side-effects and high attrition rate. Today's retroactive scaled-down virtual screening (VS) experiments relying on benchmarking datasets are extensively involved to assess ligand enrichment in the re...
Jin, Zhe Zhang, Chao Liu, Miao Jiao, Simeng Zhao, Jing Liu, Xiaoping Lin, Huangquan Chi-Cheong Wan, David Hu, Chun
Published in
Journal of biomolecular structure & dynamics
The acetylcholinesterase inhibitors play a critical role in the drug therapy for Alzheimer's disease. In this study, twenty-nine novel 3-aryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were synthesized and assayed for their human acetylcholinesterase (hAChE) inhibitory activities. Inhibitory ratio values of seventeen compounds were above 55...
