Williams, Alexander T Muller, Cynthia R Govender, Krianthan Navati, Mahantesh S Friedman, Adam J Friedman, Joel M Cabrales, Pedro
Amelioration of immune overactivity during sepsis is key to restoring hemodynamics, microvascular blood flow, and tissue oxygenation, and in preventing multi-organ dysfunction syndrome. The systemic inflammatory response syndrome that results from sepsis ultimately leads to degradation of the endothelial glycocalyx and subsequently increased vascul...
Spinler, Kyle Bajaj, Jeevisha Ito, Takahiro Zimdahl, Bryan Hamilton, Michael Ahmadi, Armin Koechlein, Claire S Lytle, Nikki Kwon, Hyog Young Anower-E-Khuda, Ferdous
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Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understanding how they are regulated. Here, we show that a knock-in reporter mouse for the stem cell gene Musas...
Choi, Yeon Sik Hsueh, Yuan-Yu Koo, Jahyun Yang, Quansan Avila, Raudel Hu, Buwei Xie, Zhaoqian Lee, Geumbee Ning, Zheng Liu, Claire
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Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimatel...
McQuade, Amanda Kang, You Jung Hasselmann, Jonathan Jairaman, Amit Sotelo, Alexandra Coburn, Morgan Shabestari, Sepideh Kiani Chadarevian, Jean Paul Fote, Gianna Tu, Christina H
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The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine this question, we profile microglia differentiated from...
Ren, Shuling Gaykalova, Daria A Guo, Theresa Favorov, Alexander V Fertig, Elana J Tamayo, Pablo Callejas-Valera, Juan Luis Allevato, Mike Gilardi, Mara Santos, Jessica
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The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype with increase in expression of E2...
Sarin, Vishesh Yu, Katharine Ferguson, Ian D Gugliemini, Olivia Nix, Matthew A Hann, Byron Sirota, Marina Wiita, Arun P
Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor cells in patients. Here, we employ a recently described method of transcriptional correlation profiling to compare similarity of 66 MM cell lines to 779 newly diagnosed MM patient tumors. We ...
Bengoa-Vergniory, Nora Faggiani, Emilie Ramos-Gonzalez, Paula Kirkiz, Ecem Connor-Robson, Natalie Brown, Liam V Siddique, Ibrar Li, Zizheng Vingill, Siv Cioroch, Milena
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Parkinson's disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of proteins undergoing amyloidogenic processes. Here we report that the molecular tweezer CLR01 decreas...
Lu, Ake T Narayan, Pritika Grant, Matthew J Langfelder, Peter Wang, Nan Kwak, Seung Wilkinson, Hilary Chen, Richard Z Chen, Jian Simon Bawden, C
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Although Huntington's disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EW...
Peng, David H Rodriguez, Bertha Leticia Diao, Lixia Chen, Limo Wang, Jing Byers, Lauren A Wei, Ying Chapman, Harold A Yamauchi, Mitsuo Behrens, Carmen
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Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade. Additionally, elevated collagen correlates with decreased total CD8+ T cells and increased exhausted CD8+ T cell subpopulations in murine and ...
Feng, Guoping Jensen, Frances E Greely, Henry T Okano, Hideyuki Treue, Stefan Roberts, Angela C Fox, James G Caddick, Sarah Poo, Mu-Ming Newsome, William T
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The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. The complex circuit formation and experience-dependent refinement of the human brain are very difficult to model in vitro, ...