Published in Egyptian Journal of Radiology and Nuclear Medicine
BackgroundPerianal fistulas are a common inflammatory condition of the anal canal and perianal tissue. The introduction of MRI in the evaluation of suspected perianal inflammation has greatly improved the surgical outcome of these patients as it allowed the direct visualization of anal sphincters, levator ani muscle, and the extent of the disease i...
This paper highlights a systematic bias in white matter tissue microstructure modelling via diffusion MRI that is due to the common, yet inaccurate, assumption that all brain tissues have a similar T2 response. We show that the concept of "signal fraction" is more appropriate to describe what have always been referred to as "volume fraction". This ...
Published in Neurosurgery
Moyamoya disease often leads to ischemic strokes visible on diffusion-weighted imaging (DWI) and T2-weighted magnetic resonance imaging (MRI) with subsequent cognitive impairment. In adults with moyamoya, apparent diffusion coefficient (ADC) is correlated with regions of steal phenomenon and executive dysfunction prior to white matter changes. To i...
Age-related differences in bimanual motor performance have been extensively documented, but their underlying neural mechanisms remain less clear. Studies applying diffusion MRI in the aging population have revealed evidence for age-related white matter variations in the corpus callosum (CC) which are related to bimanual motor performance. However, ...
Published in NeuroImage
Phase correction (PC) is a preprocessing technique that exploits the phase of images acquired in Magnetic Resonance Imaging (MRI) to obtain real-valued images containing tissue contrast with additive Gaussian noise, as opposed to magnitude images which follow a non-Gaussian distribution, e.g. Rician. PC finds its natural application to diffusion-we...
Published in Neuroimage
Probing microstructure with diffusion magnetic resonance imaging (dMRI) on a scale orders of magnitude below the imaging resolution relies on biophysical modelling of the signal response in the tissue. The vast majority of these biophysical models of diffusion in white matter assume that the measured dMRI signal is the sum of the signals emanating ...
Probing microstructure with diffusion magnetic resonance imaging (dMRI) on a scale orders of magnitude below the imaging resolution relies on biophysical modelling of the signal response in the tissue. The vast majority of these biophysical models of diffusion in white matter assume that the measured dMRI signal is the sum of the signals emanating ...
Published in Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Experiments on rodents have demonstrated that transecting the white matter fibre pathway linking the hippocampus with an array of cortical and subcortical structures - the fornix - impairs flexible navigational learning in the Morris Water Maze (MWM), as well as similar spatial learning tasks. While diffusion magnetic resonance imaging (dMRI) studi...
Published in Experimental Neurobiology
An important challenge in Parkinson’s disease (PD) based neuroscience and neuroimaging is mapping the neuronal connectivity of the basal ganglia to understand how the disease affects brain circuitry. However, a majority of diffusion tractography studies have shown difficulties in revealing connections between distant anatomic brain regions and visu...
Background: Imaging in the field of epilepsy has been a lasting challenge. In genetic generalised epilepsy (GGE) patients, conventional neuroimaging methods such as the MRI often appear normal and even in focal epilepsy (FE) an obvious structural abnormality is not always visualised. The objective of this exploratory case study is to identify white...
