We studied the D3-type cyclin function during gynoecium development in Arabidopsis and how they are related to the hormone cytokinin and the transcription factor SPATULA. Growth throughout the life of plants is sustained by cell division and differentiation processes in meristematic tissues. In Arabidopsis, gynoecium development implies a multiphas...
We discuss the mathematical modelling of two of the main mechanisms that pushed forward the emergence of multicellularity: phenotype divergence in cell differentiation and between-cell cooperation. In line with the atavistic theory of cancer, this disease being specific of multicellular animals, we set special emphasis on how both mechanisms appear...
Published in IOP Conference Series: Earth and Environmental Science
The research was conducted in 2024 at the Department of Horticulture and Landscape Design, College of Agriculture, University of Kirkuk, IRAQ, plant cell and tissue culture laboratory. The seeds of digitalis plants, which were procured from the Spanish firm Semill Asfitto, were utilized in an investigation into the impact of gibberellic acid (GA3) ...
Abstract Large-scale flank collapses are one of the main hazards associated with the evolution of volcanic islands. Precisely dating such events is critical to evaluate the frequency of destabilization episodes and further assess the triggering mechanism(s) associated with internal and/or external factors, such as volcano dynamics, regional tectoni...
Peer reviewed: True / Acknowledgements: We thank Peter Humphries and Darren Clements for assistance with microscopy, and Brian Hendrich, Nichola Reynolds, Masaki Kinoshita, Harry Leitch, Jenny Nichols and Lawrence Bates for discussions. Elena Corujo-Simon provided TS cells for positive control RT-qPCR. Pre-conjugated pA-Tn5 was a kind gift from the...
BACKGROUND: The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potential modulator of the immune response in most cancers, Keratin 17 (K17), a biomarker of the most aggressive (...
Published in In vitro cellular & developmental biology. Animal
The notion of using pluripotent stem cells (PSCs) as a source of differentiated cell types for replacement of disease or damaged tissues in regenerative medicine is now an active area of research, with approaches to treating eye diseases such as age-related macular degeneration or Parkinson's disease now on the horizon. But the foundations for this...
Published in Asian journal of surgery
Published in Biochemical and biophysical research communications
Atopic dermatitis (AD) is a chronic inflammatory skin disease where Th2-type immune responses are dominant. In the lesional skin of AD, keratinocytes show differentiation defects and secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. We previously reported that inducible loss of B-cell lymphoma 6 (Bcl6), a transc...
Published in Scientific reports
Biophysical cues from the cell microenvironment are detected by mechanosensitive components at the cell surface. Such machineries convert physical information into biochemical signaling cascades within cells, subsequently leading to various cellular responses in a stimulus-dependent manner. At the surface of extracellular environment and cell cytop...
