Published in Pulmonary pharmacology & therapeutics
Nintedanib is an important drug for the treatment of idiopathic pulmonary fibrosis (IPF). However, the drug is discontinued in some patients who present with diarrhea. In this study, we aimed to assess the drug continuation rate in patients who developed diarrhea during nintedanib therapy and to evaluate if antidiarrheal drugs or nintedanib dose re...
Being a member of the serotonin receptor family, 5-HT4 receptor ties up the neurotransmitter-serotonin (5-hydroxytryptamine/ 5-HT) in the central nervous system (CNS) of mammals. Commonly 5-HT4 receptors (5-HTR4) are G-protein-coupled receptors (GPCRs), in which the G proteins cause the induction of adenylate cyclase, subsequently leading to cyclic...
Published in Journal of Animal Science and Biotechnology
BackgroundThe effects of dietary garcinol on diarrhea and intestinal barrier function associated with its modulation of gut microbiota in weaned piglets were investigated.MethodOne hundred forty four weaned piglets (Duroc × Yorkshire × Landrace) from 16 pens (9 piglets per pen) were randomly divided into four treatment groups: controls (CON) or tho...
Published in The Korean journal of internal medicine
Diagnostic stool multiplex polymerase chain reaction (PCR) testing has attracted considerable interest, because of its high sensitivity, short turnaround time, and ability to detect multiple organisms simultaneously. This study investigates the clinical usefulness of a stool multiplex bacterial PCR in patients with acute diarrhea. We retrospectivel...
Published in BMC Infectious Diseases
BackgroundDiarrhea is responsible for 525,000 children under-five deaths and 1.7 billion cases globally and is the second leading cause of death among children under-five every year. It is a major public health problem in low income countries like Ethiopia. The main aim of this study was to assess the prevalence of diarrhea and associated risk fact...
Published in BMC Gastroenterology
BackgroundNaldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, which can cause abdominal pain and often leads to treatment discontinuation. We aimed to identify risk factors and appropriate managem...
Published in Current Infectious Disease Reports
Purpose of ReviewWe aimed to summarize the most current evidence on the main aspects of the diarrheal diseases in children. The following key elements were addressed: definitions, etiology, pathogenesis, diagnosis, dietary management, pharmacological treatments, and prevention. We covered the following questions: What are the most important clinica...
Published in MMW - Fortschritte der Medizin
Ein 34-jähriger Familienvater stellt sich mit seit drei Tagen bestehenden abdominellen Krämpfen und unblutigen Durchfällen vor. Der Beginn sei schlagartig gewesen. Der Patient ist dem Hausarzt wegen eines Morbus Crohn bekannt. Die letzte Vorstellung liegt über sechs Monate zurück.
Published in Water, Air, & Soil Pollution
In Brazil, safe drinking water is not widely available, and consequently waterborne diseases are still associated with high morbidity and mortality rates. Among waterborne bacteria, diarrheagenic Escherichia coli (DEC) should be highlighted. This study targeted the evaluation of enteropathogenic (EPEC), enterotoxigenic (ETEC), and shiga toxin-produ...
Probiotic supplementation with different lactobacilli and bifidobacterial strains has demonstrated beneficial effects in infectious diarrhea caused by rotavirus (RV) in young children. Preclinical models of RV infection might be a good strategy to screen for the efficacy of new probiotic strains or to test their comparative efficacy. Neonatal Lewis...
