Ahuja, Sukriti Saxena, Sandeep Akduman, Levent Meyer, Carsten H. Kruzliak, Peter Khanna, Vinay K.
Published in
International Journal of Retina and Vitreous
BackgroundElevated serum vascular endothelial growth factor (VEGF) levels are associated with diabetic retinopathy (DR). Serum VEGF levels correlate with vitreous levels. Neuroretinal changes occur even before the appearance of vascular signs in DR. Role of VEGF as a biomarker for DR has not been assessed. Serum VEGF as a biomarker for severity of ...
Özmen, Sedat Ağca, Sümeyra Doğan, Emine Aksoy, Nilgün Özkan Çakır, Burçin Sonalcan, Vildan Alagöz, Gürsoy
ABSTRACT Purpose: To evaluate the usefulness of fundus autofluorescence imaging of diabetic patients without retinopathy to investigate early retinal damage. Methods: Fundus autofluorescence images of patients with type 2 diabetes mellitus without retinopathy (diabetic group) and age-sex matched healthy patients (control group) were recorded with a...
youngblood, hannah robinson, rebekah sharma, ashok sharma, shruti
Diabetic retinopathy (DR), a sight-threatening neurovasculopathy, is the leading cause of irreversible blindness in the developed world. DR arises as the result of prolonged hyperglycemia and is characterized by leaky retinal vasculature, retinal ischemia, retinal inflammation, angiogenesis, and neovascularization. The number of DR patients is grow...
Berrocal, Maria H. Acaba, Luis A. Chenworth, Megan L.
Published in
Current Diabetes Reports
Purpose of ReviewDiabetic macular edema (DME) and complications of proliferative diabetic retinopathy (PDR) are the primary causes of vision loss in patients with diabetic retinopathy. As the incidence of diabetes increases worldwide, new, cost-effective treatments for DME and PDR will become paramount. Currently, anti-vascular endothelial growth f...
Honasoge, Avinash Nudleman, Eric Smith, Morton Rajagopal, Rithwick
Published in
Current Diabetes Reports
Purpose of ReviewTo introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss.Recent FindingsAdvances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies exist long before the development o...
Ho, Kam Chun Stapleton, Fiona Wiles, Louise Hibbert, Peter Alkhawajah, Sally White, Andrew Jalbert, Isabelle
Published in
BMC Health Services Research
BackgroundHealth care systems are continually being reformed, however care improvement and intervention effectiveness are often assumed, not measured. This paper aimed to review findings from published studies about the appropriateness of eye care delivery, using existing published evidence and/or experts’ practice and to describe the methods used ...
Kwan, Changyow C. Fawzi, Amani A.
Published in
Current Diabetes Reports
Purpose of ReviewDiabetic retinopathy (DR) is the leading cause of acquired vision loss in adults across the globe. Early identification and treatment of patients with DR is paramount for vision preservation. The aim of this review paper is to outline current and new imaging techniques and biomarkers that are valuable for clinical diagnosis and man...
Xiao, Qing Zhao, Yinu Xu, Jia Li, Wen-Jie Chen, Yu Sun, Hong-Jing
Published in
BMC Molecular and Cell Biology
BackgroundA study has shown that miR-423-5p is highly expressed in proliferative diabetic retinopathy. However, the exact biological functions and mechanisms of miR-423-5p in diabetic retinopathy (DR) progression are currently unclear. This study aimed to investigate the role of miR-423-5p in DR and the underlying mechanism.ResultsOur data demonstr...
Hu, Yuxiang Cheng, Yi Xu, Xiaoxuan Yang, Bo Mei, Feng Zhou, Qiong Yan, Li Wang, Jun Wu, Xiaorong
Published in
BMC Ophthalmology
BackgroundTo investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab.MethodsWe retrospectively analyzed the medical records of all patients who received intravitreal ranibizumab (IVR) treatment for DME at the First Affiliated Hospital of Nanchang Uni...
Zhang, Lan Yu, Jie Ye, Mingxia Zhao, Hailan
Published in
Cell & Bioscience
PurposeThe aim of this study was to investigate the underlying mechanisms of diabetic retinopathy (DR) development.MethodsReal-Time qPCR was used to detect Casein kinase 2 interacting protein-1 (CKIP-1) and Nuclear factor E2-related factor 2 (Nrf2) mRNA levels. Western Blot was employed to detect protein levels. Malondialdehyde (MDA) assay kit, sup...
