Published in Cardiovascular Diabetology
BackgroundSince studies of the relationship between carotid disease and diabetic retinopathy (DR) have shown apparent inconsistencies, the aim of this study was to conduct a systematic review of available published data.MethodsElectronic databases were searched independently by two reviewers, according to an iterative protocol, for relevant article...
Published in Karger Kompass Ophthalmologie
Background: Diabetic retinopathy is characterised by morphological lesions in the retina secondary to disturbances in retinal blood flow. Previous studies have shown that the carbonic anhydrase inhibitor (CAI) dorzolamide can induce immediate dilatation of retinal arterioles and a sustained increase in retinal blood flow in primary open-angle glauc...
Published in Experimental eye research
Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways involved in their effects are currently unknown. To understand the role of diabetes-induced molecular al...
Published in Experimental eye research
Animal studies suggest that the retinal dysfunction in diabetic subjects that precedes overt clinical vasculopathy may be due to a retinal dopamine deficit. We analyzed levels of dopamine (DA) and its primary metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the vitreous of diabetic and non-diabetic human subjects. Adult patients undergoing pa...
Published in Bulletin of the National Research Centre
BackgroundDiabetic retinopathy is one of the common microvascular complications of diabetes. The formation of advanced glycation end products (AGE) exerts deleterious effects by acting directly to induce cross-linking of proteins promoting vascular damage. Hyperglycemia causes disturbance in glycogenesis pathway resulting in reduction of glucose to...
Published in BMC Public Health
BackgroundDiabetic Retinopathy is one of the serious complications patients’ diabetic patients suffer from. Little is known about which risk factors are associated with this complication. The aim of this study was therefore to identify determinants of Diabetic Retinopathy in Jimma University Medical Center.MethodsA facility-based case-control study...
Published in BMC Nephrology
BackgroundDiabetic nephropathy (DN) is the most prevalent cause of renal disease in type 2 diabetic patients and is usually diagnosed clinically. A kidney biopsy is considered when non-diabetic renal disease (NDRD) is suspected, such as rapid progression in renal function impairment and severe proteinuria. Still, there is yet no consensus on the ti...
Published in Bulletin of the National Research Centre
BackgroundDiabetic retinopathy is a multistage event, and the most important of it is angiogenesis. The possible association between vascular endothelial growth factor (VEGF) +405G/C gene polymorphism and various diseases, in which angiogenesis might be critical in disease development, encourages many investigators to study its role in diabetic ret...
Published in Eye and Vision
BackgroundEffective screening is a desirable method for the early detection and successful treatment for diabetic retinopathy, and fundus photography is currently the dominant medium for retinal imaging due to its convenience and accessibility. Manual screening using fundus photographs has however involved considerable costs for patients, clinician...
Published in Cost Effectiveness and Resource Allocation
BackgroundDiabetic retinopathy (DR) is a significant global public health and economic burden. DR accounts for approximately 15–17% of all cases of total blindness in the USA and Europe. Telemedicine is a new intervention for DR screening, however, there is not enough evidence to support its cost-effectiveness. The aim of this study is to review th...
