Qi, Sha Han, Qiong Xing, Danmou Qian, Long Yu, Xiang Ren, Dong Wang, Huan Chen, Quan
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Diabetic wound (DW) treatment is a serious challenge for clinicians, and the underlying mechanisms of DWs remain elusive. We sought to identify the critical genes in the development of DWs and provide potential targets for DW therapies. Material/Methods Datasets of GSE38396 from the Gene Expression Omnibus (GEO) database were reviewed. P...
Niechciał, Elżbieta Acerini, Carlo L Chiesa, Scott T Stevens, Tracey Dalton, R Neil Daneman, Denis Deanfield, John E Jones, Timothy W Mahmud, Farid H Marshall, Sally M
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OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim was to assess adherence to ACE inhibitors and statins and explore potential determinants in adolescents with type 1 diabete...
Fei, Ji Ling, Yi-Ming Zeng, Man-Jie Zhang, Kai-Wei
Published in
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Background Shixiang plaster is a traditional Chinese medicine has been used to treat chronic ulcers, including diabetic ulcers. Aminoguanidine is a hydrazine derivative that inhibits the formation of advanced glycosylation end products (AGEs). This study aimed to investigate the effects of shixiang plaster and aminoguanidine on wound healing in the...
Ray, Kausik K Nicholls, Stephen J Ginsberg, Henry D Johansson, Jan O Kalantar-Zadeh, Kamyar Kulikowski, Ewelina Toth, Peter P Wong, Norman Cummings, Jeffrey L Sweeney, Michael
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After an acute coronary syndrome (ACS), patients with diabetes remain at high risk for additional cardiovascular events despite use of current therapies. Bromodomain and extra-terminal (BET) proteins are epigenetic modulators of inflammation, thrombogenesis, and lipoprotein metabolism implicated in atherothrombosis. The BETonMACE trial tests the hy...
Verma, Nirmal Liu, Miao Ly, Han Loria, Analia Campbell, Kenneth S Bush, Heather Kern, Philip A Jose, Pedro A Taegtmeyer, Heinrich Bers, Donald M
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In the setting of type-2 diabetes, there are declines of structural stability and functionality of blood capillaries and red blood cells (RBCs), increasing the risk for microcirculatory disturbances. Correcting hyperglycemia is not entirely effective at reestablishing normal cellular metabolism and function. Therefore, identification of pathologica...
Duprez, Daniel A Forbang, Nkete I Allison, Matthew A Peralta, Carmen A Shea, Steven Jacobs, David R
BackgroundAlthough microvascular dysfunction is known to result from diabetes, it might also lead to diabetes. Lower values of C2, a derivative of the radial artery pressure waveform, indicate microvascular dysfunction and predict hypertension and cardiovascular disease (CVD). We studied the association of C2 with incident diabetes in subjects free...
Mazarello Paes, Veena Barrett, Jessica K Taylor-Robinson, David C Chesters, Heather Charalampopoulos, Dimitrios Dunger, David B Viner, Russell M Stephenson, Terence J
OBJECTIVE: A systematic review and meta-analysis was conducted to investigate if glycemic control measured by glycated hemoglobin (HbA1c) levels near diagnosis are predictive of future glycemic outcomes and vascular complications in childhood onset type 1 diabetes (T1D). METHODS: Evidence was gathered using electronic databases (MEDLINE, EMBASE, We...
Owusu Adjah, Ebenezer S. Ray, Kausik K. Paul, Sanjoy K.
Published in
Acta Diabetologica
AimTo evaluate the risk of CVD and all-cause mortality at different BMI levels in conjunction with weight change prior to diagnosis of T2DM in a multi-ethnic population.MethodsLongitudinal study of 51,455 patients with T2DM and without a history of comorbid diseases at diagnosis. Weight changes prior to diagnosis of T2DM were evaluated, and the ris...
Webb, David Dales, Jolyon Zaccardi, Francesco Hill, Sian Moore, Corran Farooqi, Azhar Griffin, Simon Davies, Melanie Khunti, Kamlesh
AIMS: Diabetes treatment algorithms recommend intensive intervention in those with a shorter duration of disease. Screening provides opportunities for earlier multifactorial cardiovascular risk factor control. Using data from the ADDITION-Leicester study (NCT00318032), we estimated the effects of this approach on modelled risk of diabetes-related c...
Kim, Ung Leipsic, Jonathon A Sellers, Stephanie L Shao, Michael Blanke, Philipp Hadamitzky, Martin Kim, Yong-Jin Conte, Edoardo Andreini, Daniele Pontone, Gianluca
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ObjectivesThis study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM).BackgroundThe natural history of coronary PP in patients with DM is not well established.MethodsA total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median s...
