Yoon, Chang Ki Sagong, Min Shin, Jae Pil Lee, Sang Joon Lee, Joo Eun Lee, Ji Eun Chung, Inyoung Jeong, Woo Jin Pak, Kang Yeun Kim, Hyun Woong
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Published in
BMC Ophthalmology
BackgroundTo investigate the effect of intravitreal dexamethasone implant (DEX implant) on hard exudate (HE) accompanying diabetic macular edema (DME).MethodsThis study was a non-comparative non-randomized 1-year prospective interventional study. Patients with DME and HE were treated using DEX implant two or three times. Color fundus photography an...
Kumar, Raman Rathi, Himani Haq, Afrozul Wimalawansa, Sunil J Sharma, Alpana
Published in
Virus research
The first incidence of COVID-19 was reported in the Wuhan city of Hubei province in China in late December 2019. Because of failure in timely closing of borders of the affected region, COVID-19 spread across like a wildfire through air travel initiating a pandemic. It is a serious lower respiratory track viral infection caused by highly contagious,...
Minarik, Jiri Pika, Tomas Radocha, Jakub Jungova, Alexandra Straub, Jan Jelinek, Tomas Pour, Ludek Pavlicek, Petr Mistrik, Martin Brozova, Lucie
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Published in
BMC Cancer
BackgroundWe have performed a head to head comparison of all-oral triplet combination of ixazomib, lenalidomide and dexamethasone (IRD) versus lenalidomide and dexamethasone (RD) in patients with relapsed and refractory multiple myeloma (RRMM) in the routine clinical practice.MethodsA total of 344 patients treated with IRD (N = 127) or RD (N = 217)...
Ashoor, Tarek M. Hussien, Noha S. Anis, Sherif G. Esmat, Ibrahim M.
Published in
BMC Anesthesiology
BackgroundPost-spinal anesthesia (PSA) hypotension in elderly patients is challenging. Correction of PSA hypotension by fluids either colloids or crystalloids or by vasoconstrictors pose the risk of volume overload or compromising cardiac conditions. Dexamethasone is used to treat conditions manifested by decrease of peripheral vascular resistance....
Chen, Ye Zhang, Chao Xiao, Chang-xue Li, Xiao-dong Hu, Zhi-li He, Shou-di Xiao, Xiao-jun Xu, Feng
Published in
Journal of Inflammation
ObjectiveTo investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment.MethodsIL-1β (10 ng/mL) and LPS (1 μg/mL) was used to construct inflammatory cell models with A549 cells; IL-1β performed better against LPS. Different concentrations of Dex were used to attenuate the inflammation in...
Li, Tao Xu, Yingxing Wang, Yingzhen Jiang, Yaping
Published in
Stem Cell Research & Therapy
BackgroundAbnormalities in apoptosis, cell cycle, proliferation, and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, resulting in various skeletal disorders. Long-term exposure to a high dosage of dexamethasone (Dex) induces apoptosis and inhibits the proliferation of mesench...
Vasconcelos, Mateus Meira Pontes, João Paulo Jordão Rodrigues, Alexandre de Menezes Brito Neto, Demócrito Ribeiro de Alves, Rodrigo Rodrigues Silva, Fernando Cássio do Prado Souza, Denis Fabiano de
Abstract Background and objectives: In shoulder arthroscopy, on an outpatient basis, the patient needs a good control of the postoperative pain that can be achieved through regional blocks. Perineural dexamethasone may prolong the effect of these blocks. The aim of this study was to evaluate the effect of perineural dexamethasone on the prolongatio...
Zhang, Yongjing Hu, Shiling Wang, Jue Xue, Zhuoyin Wang, Cheng Wang, Nan
Published in
Virology
The SARS-CoV-2 outbreak, began in late 2019, has caused a worldwide pandemic and shows no signs of slowing. Glucocorticoids (GCs), including dexamethasone (DEX), have been widely used as effective anti-inflammatory and immunosuppressant drugs. In this study, seven GCs had no obvious effect on cell viability of angiotensin converting enzyme 2 (ACE2)...
Muraki, Masato Kita, Hirohito Gleich, Gerald J.
Published in
Clinical and Molecular Allergy
BackgroundEosinophils play an important role in allergic inflammation. Glucocorticosteroids have been used as an anti-inflammatory medication for inflammatory diseases involving eosinophil infiltration. Some effect of nebulized lidocaine has been reported when treating certain patients with asthma, which is also an inflammatory disease. The goal of...
Ye, Xiaolian Zou, Gang Hou, Jinxing Bi, Huiru Zhou, Cuihua Wang, Runmin Xu, Yun Wang, Chun Chen, Guiquan Yin, Zhenyu
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Published in
Biochemistry and biophysics reports
Prolonged neuroinflammation is a driving force for neurodegenerative disease, and agents against inflammatory responses are regarded as potential treatment strategies. Here we aimed to evaluate the prevention effects on gliosis by dexamethasone (DEX), an anti-inflammation drug. We used DEX to treat the nicastrin conditional knockout (cKO) mouse, a ...