Dendrobium Nobile Lindl. Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity
Published in Frontiers in Pharmacology
Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine...
Published in Current neuropharmacology
High methionine-diet (HMD) causes Alzheimer's disease (AD)-like symptoms. Previous studies have shown that Dendrobium nobile Lindle. alkaloids (DNLA) have potential benefits for AD Object: The objective of this study has been to explore whether DNLA can improve AD-like symptoms induced by HMD. Mice were fed with 2% HMD diet for 11 weeks; the DNLA20...
Dendrobium nobile Lindl. alkaloids alleviate Mn-induced neurotoxicity via PINK1/Parkin-mediated mitophagy in PC12 cells
Published in Biochemistry and Biophysics Reports
• Dendrobium nobile Lindl. alkaloids (DNLA) significantly alleviate cytotoxicity of PC12 cells induced by manganese (Mn) and improve mitochondrial function. • Activation of PINK1/Parkin-mediated autophagic flux is involved in the protective action of DNLA on Mn-induced neurotoxicity. • DNLA reduces Mn-induced ROS generation and suppresses Mn-induce...
