Loughland, Jessica R. Woodberry, Tonia Oyong, Damian Piera, Kim A. Amante, Fiona H. Barber, Bridget E. Grigg, Matthew J. William, Timothy Engwerda, Christian R. Anstey, Nicholas M.
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Published in
Malaria Journal
Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria. This study investigated circulating DC and Flt3L associati...
Liu, Shudong Wang, Jie Li, Wenyan Shi, Hui Zhou, Changlong Tang, Ge Zhang, Jiangwei Yang, Zhao
Published in
Journal of Inflammation
IntroductionTIPE-2 has been identified as a negative regulator of both innate and adaptive immunity and is involved in several inflammatory diseases. However, the role of immune suppression of dendritic cells (DCs) transduced with TIPE-2 has not been well studied.MethodsIn this study, DCs were transduced with TIPE-2 recombinant adenovirus, and then...
Mei, Yan Wang, Mingdian Lu, Guanming Li, Jiangchao Peng, Lixia Lang, Yanhong Yang, Mingming Jiang, Lingbi Li, Changzhi Zheng, Lisheng
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Published in
Cancer Cell International
BackgroundIt has been known for years that the same genetic defects drive breast cancer formation, yet, the onset of breast cancer in different individuals among the same population differs greatly in their life spans with unknown mechanisms.MethodsWe used a MMTV-PyMT mouse model with different genetic backgrounds (FVB/NJ vs. C57BL/6J) to generate ...
Wang, Yaping Liao, Kou Liu, Bo Niu, Chao Zou, Wenjing Yang, Lili Wang, Ting Tian, Daiyin Luo, Zhengxiu Dai, Jihong
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Published in
Respiratory Research
BackgroundGlucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathogenesis of allergic asthma. In this study, we investigated whether regulating GITRL expressed on dendritic cells (DCs) can prevent as...
Kim, Chae Won Kim, Kyun-Do Lee, Heung Kyu
Published in
BMB Reports
Dendritic cells (DC), which consist of several different subsets, specialize in antigen presentation and are critical for mediating the innate and adaptive immune responses. DC subsets can be classified into conventional, plasmacytoid, and monocyte-derived DC in the tumor microenvironment, and each subset plays a different role. Because of the role...
Papaioannou, Nikos E. Salei, Natallia Rambichler, Stephan Ravi, Kaushikk Popovic, Jelena Küntzel, Vanessa Lehmann, Christian H. K. Fiancette, Remi Salvermoser, Johanna Gajdasik, Dominika W.
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Published in
Nature Communications
Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper sti...
Turner, Triniti C. Arama, Charles Ongoiba, Aissata Doumbo, Safiatou Doumtabé, Didier Kayentao, Kassoum Skinner, Jeff Li, Shanping Traore, Boubacar Crompton, Peter D.
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Published in
Malaria Journal
BackgroundPlasmodium falciparum causes the majority of malaria cases worldwide and children in sub-Saharan Africa are the most vulnerable group affected. Non-sterile clinical immunity that protects from symptoms develops slowly and is relatively short-lived. Moreover, current malaria vaccine candidates fail to induce durable high-level protection i...
Wang, Haiting Teng, Xiangyu Abboud, Georges Li, Wei Ye, Shuang Morel, Laurence
Published in
BMC Immunology
BackgroundSystemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C− 2 epimer of glucose that exhibits immunoregulatory effects in models of autoimmune diseases, such as type 1 diabetes, induced rheumatoid arthritis, and air...
Srivastava, Niharika Bishnoi, Anuradha Parsad, Davinder Kumaran, Muthu Sendhil Vinay, Keshavamurthy Gupta, Sarika
Published in
Archives of dermatological research
In autoimmune onset of vitiligo, perilesional area shows inflammatory cells including T cytotoxic, helper cells and macrophages. Dendritic Cells (DCs) regulate immune activities by antigen presentation to T cells or cytokine production. It is evident that pro- and anti-inflammatory DCs are responsible for their respective cytokines release. However...
Yabe, Rikio Chung, Soo-Hyun Murayama, Masanori A. Kubo, Sachiko Shimizu, Kenji Akahori, Yukiko Maruhashi, Takumi Seno, Akimasa Kaifu, Tomonori Saijo, Shinobu
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Published in
Nature Communications
TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthritis in mice.
