Han, Jiaochan Li, Xing Luo, Xiaoqing He, Juan Huang, Xuechan Zhou, Qingyou Han, Yanping Jie, Hongyu Zhuang, Jian Li, Yehao
...
Published in
Biomedicine & Pharmacotherapy
Hydroxychloroquine (HCQ) is one of the most commonly prescribed immune-suppressants in treating rheumatoid arthritis (RA). Our previous research showed that HCQ suppressed RA development by inhibiting T follicular helper (Tfh) cells directly. Dendritic cells (DCs) serve as the link between innate and acquired immunity. Whether HCQ suppressed Tfh ce...
Pérez-Rodríguez, Leticia Martínez-Blanco, Mónica Lozano-Ojalvo, Daniel Molina, Elena López-Fandiño, Rosina
Published in
European journal of nutrition
Egg yolk (EY) may play a role during the sensitizing phase of egg allergy by exerting intestinal type 2-biasing effects. We aimed to identify the mechanism and role of EY in the induction of allergy to egg white (EW). BALB/c mice were exposed intragastrically to EW, EY, or the mixture of EW:EY. In addition in vitro experiments were conducted with i...
Scalavino, Viviana Liso, Marina Cavalcanti, Elisabetta Gigante, Isabella Lippolis, Antonio Mastronardi, Mauro Chieppa, Marcello Serino, Grazia
Published in
Scientific Reports
Dendritic cells are the most important antigen-presenting cells that link the innate and acquired immune system. In our previous study, we identified that the upregulation of miR-369-3p suppresses the LPS-induced inflammatory response, reducing C/EBP-β, TNFα and IL-6 production. With the aim of gaining further insight into the biological function o...
Jia, Jia Zheng, Kai Shen, Hong Yu, Jiangyi Zhu, Ping Yan, Shihai Xu, Yi Zhu, Lei Lu, Yuelin Gu, Peiqing
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Published in
BMC Complementary Medicine and Therapies
BackgroundThe balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is involved in immunological tolerance. Destruction of immunological tolerance by dendritic cell (DC)-mediated T cells is involved in the pathogenesis of ulcerative colitis (UC). Qingchang Huashi granule (QCHS) has been confirmed in the treatment of UC involved by...
Ramos, Maria Ines Garcia, Samuel Helder, Boy Aarrass, Saida Reedquist, Kris. A. Jacobsen, Sten E. Tak, Paul Peter Lebre, Maria Cristina
Published in
Journal of Translational Autoimmunity
• Flt3L independent DCs present in Flt3L−/− mice are functional but are not sufficient to induce arthritis. • BATF3−/− mice lacking cDC1 are protected from arthritis development indicating that cDC1 are necessary for disease induction. • Treatment with a Flt3L inhibitor, CEP701, reduced cDC1 populations and prevented arthritis induction.
Alesci, Alessio Lauriano, Eugenia Rita Aragona, Marialuisa Capillo, Gioele Pergolizzi, Simona
Published in
Acta Histochemica
Langerhans cells (LCs) are specialized dendritic cells (DCs) that play a defense role in recognizing foreign antigens, in tissue where antigenic exposures occur, as in the skin and mucous membranes. LCs are able to continuously move within the tissues thanks to dendritic contraction and distension performing their surveillance and/or phagocytosis r...
Delaunay, Tiphaine Achard, Carole Grégoire, Marc Tangy, Frédéric Boisgerault, Nicolas Fonteneau, Jean-François
Published in
Methods in molecular biology (Clifton, N.J.)
Oncolytic immunotherapy efficacy relies partially on the induction of immunogenic tumor cell death following infection with oncolytic viruses (OV) to induce an antitumor immune response. Here, we describe a method to determine if an OV is able to induce such an immunogenic tumor cell death. This method consists in testing whether tumor cells lysed ...
Kwon, Yong-Rim Kim, Hye Joung Sohn, Min-Jung Lim, Ji-Young Park, Kyung-Shin Lee, Seok Chung, Nack-Gyun Jeong, Dae-Chul Min, Chang-Ki Kim, Yoo-Jin
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Published in
Experimental Hematology & Oncology
BackgroundSuccessful prevention of post-transplantation relapse after donor lymphocyte infusion (DLI) depends on its capability to mediate an effective graft-versus-leukemia (GVL) response while minimizing DLI-related toxicity, including graft-versus-host disease (GVHD).MethodsWe assessed the effects of decitabine (DEC), a hypomethylating agent, up...
Piperno, Giulia Maria Naseem, Asma Silvestrelli, Giulia Amadio, Roberto Caronni, Nicoletta Cervantes-Luevano, Karla Evelia Liv, Nalan Klumperman, Judith Colliva, Andrea Ali, Hashim
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Published in
JCI Insight
Excessive innate cell responses in WASp-null cells depend on activation of the cGAS/STING pathway.
Pointner, Lisa Bethanis, Athanasios Thaler, Michael Traidl-Hoffmann, Claudia Gilles, Stefanie Ferreira, Fatima Aglas, Lorenz
Published in
Clinical and Translational Allergy
The mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the a...
