Published in Parasites & Vectors
BackgroundTsetse-transmitted trypanosomosis is a deadly, neglected tropical disease and a major challenge for mixed crop-livestock agriculture in sub-Saharan Africa. It is caused by several species of the genus Trypanosoma. Information on the occurrence of tsetse flies and African animal trypanosomosis (AAT) is available for different areas of Mali...
Published in Network Modeling Analysis in Health Informatics and Bioinformatics
Numerous unbearable chronic illnesses are characterised by the presence of fatigue, the extreme exhaustion that does not improve with rest. Chronic fatigue syndromes (CFS) is one of the most commonly reported medical complaint that demand patients to seek medical care. This fatigue becomes complex to describe being a lifelong condition and even ple...
Published in Orphanet Journal of Rare Diseases
BackgroundThe dysfunction of OPA1, a dynamin GTPase involved in mitochondrial fusion, is responsible for a large spectrum of neurological disorders, each of which includes optic neuropathy. The database dedicated to OPA1 (https://www.lovd.nl/OPA1), created in 2005, has now evolved towards a centralized and more reliable database using the Global Va...
Published in 3 Biotech
Alzheimer’s disease (AD) is an age-related, non-reversible, and progressive brain disorder. Memory loss, confusion, and personality changes are major symptoms noticed. AD ultimately leads to a severe loss of mental function. Due to lack of effective biomarkers, no effective medication was available for the complete treatment of AD. There is a need ...
Published in Journal of Translational Medicine
BackgroundDiabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) all over the world, especially in high- and middle-income countries. Most DN has been present for years before it is diagnosed. Currently, the treatment of DN is mainly ...
This paper will present the results of an ongoing research on video game tutorials. Although being a widespread feature of video games, tutorials have been little studied in the field of game studies so far. The few research works on that topic address it indirectly, either as a game design issue (how to design a good tutorial? See Schell, 2008 or ...
Published in Journal of Cheminformatics
Natural products (NPs), often also referred to as secondary metabolites, are small molecules synthesised by living organisms. Natural products are of interest due to their bioactivity and in this context as starting points for the development of drugs and other bioactive synthetic products. In order to select compounds from virtual libraries, Ertl ...
AbstractIn order to provide a global overview of genotypic, epidemiologic, demographic, phylogeographical, and drug resistance characteristics related to the prevailing tuberculosis (TB) epidemic, we hereby report an update of the 6th version of the international genotyping database SITVIT2. We also make all the available information accessible thr...
Published in Earth, Planets and Space
The extensive lava piles of Iceland contain a unique record of geomagnetic field variations spanning the past ~ 16 Ma. Since the 1950s, palaeomagnetic data have been obtained from over 9400 Icelandic lavas. We have compiled all palaeomagnetic data currently available and developed a publicly accessible database (http://www.icepmag.org). The data wi...
Matrix multiplication is a mathematical brick for solving many real life problems. We consider the Strassen-Winograd algorithm (SW), one of the most efficient matrix multiplication algorithms. Our first contribution is to redesign SW with the MapReduce programming model that allows to process big data sets in parallel on a cluster. Moreover, our ma...
