Tsurugizawa, Tomokazu
Published in
Frontiers in Neuroscience
Autism spectrum disorder (ASD) is a heterogeneous syndrome characterized by behavioral features such as impaired social communication, repetitive behavior patterns, and a lack of interest in novel objects. A multimodal neuroimaging using magnetic resonance imaging (MRI) in patients with ASD shows highly heterogeneous abnormalities in function and s...
Kornaropoulos, Evgenios N. Winzeck, Stefan Rumetshofer, Theodor Wikstrom, Anna Knutsson, Linda Correia, Marta M. Sundgren, Pia C. Nilsson, Markus
Published in
Frontiers in Neurology
There are many ways to acquire and process diffusion MRI (dMRI) data for group studies, but it is unknown which maximizes the sensitivity to white matter (WM) pathology. Inspired by this question, we analyzed data acquired for diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) at 3T (3T-DTI and 3T-DKI) and DTI at 7T in patients wit...
Hsieh, Shulan Yang, Meng-Heng
Published in
Frontiers in Aging Neuroscience
Cognitive aging, especially cognitive control, and processing speed aging have been well-documented in the literature. Most of the evidence was reported based on cross-sectional data, in which inter-individual age effects were shown. However, there have been some studies pointing out the possibility of overlooking intra-individual changes in cognit...
Lee, Wha Jin Brown, Jesse A Kim, Hye Ryun La Joie, Renaud Cho, Hanna Lyoo, Chul Hyoung Rabinovici, Gil D Seong, Joon-Kyung Seeley, William W
Published in
Neuron
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it remains unclear how these proteins interact to promote disease. Here, by combining cross-sectional and longitudinal molecular imaging and network connectivity analyses in living humans, we identified two amyloid-beta/tau interactions associated with the onset ...
Sihvonen, Aleksi J Siponkoski, Sini-Tuuli Martínez-Molina, Noelia Laitinen, Sari Holma, Milla Ahlfors, Mirja Kuusela, Linda Pekkola, Johanna Koskinen, Sanna Särkämö, Teppo
...
Published in
Journal of clinical medicine
Traumatic brain injury (TBI) is a common and devastating neurological condition, associated often with poor functional outcome and deficits in executive function. Due to the neuropathology of TBI, neuroimaging plays a crucial role in its assessment, and while diffusion MRI has been proposed as a sensitive biomarker, longitudinal studies evaluating ...
Chen, Senlin Wang, Ying Wu, Xianyong Chang, Jianchao Jin, Weiming Li, Wei Song, Peiwen Wu, Yuanyuan Zhu, Jiajia Qian, Yinfeng
...
Published in
Frontiers in Aging Neuroscience
Degenerative cervical myelopathy is a progressive neurodegenerative disease, that has become increasingly prevalent in the aging population worldwide. The current study determined the factors affecting degeneration in the sensorimotor tract with degenerative cervical myelopathy and its relationship with brain structure. We divided patients into hyp...
Elliott, Blake L D'Ardenne, Kimberlee Mukherjee, Prerona Schweitzer, Julie B McClure, Samuel M
Published in
Biological psychiatry. Cognitive neuroscience and neuroimaging
Impulsivity is a defining characteristic of attention-deficit/hyperactivity disorder (ADHD), which has been associated with substance use disorders, higher accident rates, and lower educational and occupational outcomes. The meso- and nigrostriatal pathways of the dopamine system are hypothesized to be functionally heterogeneous, supporting diverse...
Langley, Jason Hussain, Sana Huddleston, Daniel E Bennett, Ilana J Hu, Xiaoping P
Published in
Brain connectivity
Introduction: Locus coeruleus (LC) is the primary source of norepinephrine to the brain and its efferent projections innervate many brain regions, including the thalamus. The LC degrades with normal aging, but not much is known regarding whether its structural connectivity evolves with age or predicts aspects of cognition. Methods: Here, we use hig...
Geli, Janos Capoccia, Massimo Maybauer, Dirk M Maybauer, Marc O
Published in
Journal of intensive care medicine
Heparin is the widely used anti-coagulation strategy for patients on extracorporeal membrane oxygenation (ECMO). Nevertheless, heparin-induced thrombocytopenia (HIT) and acquired anti-thrombin (AT) deficiency preclude the use of heparin requiring utilization of an alternative anticoagulant agent. Direct thrombin inhibitors are being proposed as pot...
Klistorner, Samuel Barnett, Michael H Yiannikas, Con Barton, Joshua Parratt, John You, Yuyi Graham, Stuart L Klistorner, Alexander
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Expansion of chronic multiple sclerosis (MS) lesion is associated with slow-burning inflammation at lesion rim. However, the underlying mechanisms leading to expansion are not fully understood. To investigate the relationship between diffusivity markers of demyelination and axonal loss in perilesional white matter and lesion expansion in relapsing-...