Štiavnická, Miriama Chaulot-Talmon, Aurélie Perrier, Jean-Philippe Hošek, Petr Kenny, David A. Lonergan, Patrick Kiefer, Hélène Fair, Sean
Published in
BMC Genomics
Background Despite a multifactorial approach being taken for the evaluation of bull semen quality in many animal breeding centres worldwide, reliable prediction of bull fertility is still a challenge. Recently, attention has turned to molecular mechanisms, which could uncover potential biomarkers of fertility. One of these mechanisms is DNA methyla...
Costes, Valentin Chaulot-Talmon, Aurélie Sellem, Eli Perrier, Jean-Philippe Aubert-Frambourg, Anne Jouneau, Luc Pontlevoy, Charline Hozé, Chris Fritz, Sébastien Boussaha, Mekki
...
Published in
Clinical epigenetics
Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial insemination represent a relevant model in this field, as the broad dissemination of bull semen considerably alleviates confounding factors a...
Uddin, Md Sahab Mamun, Abdullah Al Alghamdi, Badrah S Tewari, Devesh Jeandet, Philippe Sarwar, Md Shahid Ashraf, Ghulam Md
Published in
Seminars in cancer biology
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be mild and slowly aggravated, although other symptoms might demonstrate it as an acute ailment. However, the precise mechanisms of the development of GBM remain unknown. Due to the ...
He, Biqi Dong, Siyuan Chen, Qun Dong, Zhaoheng Chen, Chen
Published in
Biological trace element research
Fluorosis often causes female reproductive dysfunction. A rapid turnover of DNA methylation is a pathological change in many human diseases, including female reproductive dysfunction. The role of DNA methylation in fluorosis was unknown and investigated in this experiment. Fifty fluorosis women patients were selected as High F group and forty-six h...
Liu, Dongjing Zusman, Benjamin E Shaffer, John R Li, Yunqi Arockiaraj, Annie I Liu, Shuwei Weeks, Daniel E Desai, Shashvat M Kochanek, Patrick M Puccio, Ava M
...
Published in
Neurocritical care
Cerebral edema and intracranial hypertension are major contributors to unfavorable prognosis in traumatic brain injury (TBI). Local epigenetic changes, particularly in DNA methylation, may influence gene expression and thus host response/secondary injury after TBI. It remains unknown whether DNA methylation in the central nervous system is associat...
Khan, Parvez Siddiqui, Jawed Akhtar Maurya, Shailendra Kumar Lakshmanan, Imayavaramban Jain, Maneesh Ganti, Apar Kishor Salgia, Ravi Batra, Surinder Kumar Nasser, Mohd Wasim
Published in
Seminars in cancer biology
Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Most of the conventional drug disc...
Su, Riya Wu, Xinlin Tao, Liang Wang, Changshan
Published in
Clinical & experimental metastasis
Distant metastasis is the major contributor to the high mortality rate of colorectal cancer (CRC). To overcome the poor prognosis caused by distant metastasis, the mechanisms of CRC metastasis should be further explored. Epigenetic events are the main mediators of gene regulation and further affect tumor progression. Recent studies have found that ...
Akhtar, Sabah Hourani, Shireen Therachiyil, Lubna Al-Dhfyan, Abdullah Agouni, Abdelali Zeidan, Asad Uddin, Shahab Korashy, Hesham M
Published in
Seminars in cancer biology
Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that have been proposed as a strong sustainer and promoter of tumorigenesis and therapeutic resistance. These distinguished properties of CSCs have raised interest in understanding the molecular mechanisms that g...
Ortiz-Barahona, Vanessa Joshi, Ricky S Esteller, Manel
Published in
Seminars in cancer biology
DNA methylation is a highly regulated process that has a critical role in human development and homeostatic control of the cell. The number of genes affected by anomalous DNA methylation in cancer-associated pathways is swiftly accelerating and with the advancement of molecular technologies, new layers of complexity are opening up and refining our ...
Davalos, Veronica García-Prieto, Carlos A Ferrer, Gerardo Aguilera-Albesa, Sergio Valencia-Ramos, Juan Rodríguez-Palmero, Agustí Ruiz, Montserrat Planas-Serra, Laura Jordan, Iolanda Alegría, Iosune
...
Published in
EClinicalMedicine
Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syn...
