Cabezón, M. Malinverni, R. Bargay, J. Xicoy, B. Marcé, S. Garrido, A. Tormo, M. Arenillas, L. Coll, R. Borras, J.
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Published in
Clinical Epigenetics
BackgroundEpigenetic therapy, using hypomethylating agents (HMA), is known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who are not suitable for intensive chemotherapy and/or allogeneic stem cell transplantation. However, response rates to HMA are low and there is an unmet n...
Robinson, N. Brown, H. Antoun, Elie Godfrey, Keith M. Hanson, Mark A. Lillycrop, Karen A. Crozier, Sarah R. Murray, Robert Pearce, M. S. Relton, C. L.
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Published in
Clinical Epigenetics
BackgroundHigh early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised mechanism linking early life exposures and subsequent disease. However, epigenetic changes associated with high early weight gain have not previously been investigated. Our aim was to inv...
Cox, Olivia H Song, Ha Young Garrison-Desany, Henri M Gadiwalla, Nuriya Carey, Jenny L Menzies, Julia Lee, Richard S
Published in
Epigenetics
Exposure to stress or glucocorticoids (GCs) is associated with epigenetic and transcriptional changes in genes that either mediate or are targets of GC signalling. FKBP5 (FK506 binding protein 5) is one such gene that also plays a central role in negative feedback regulation of GC signalling and several stress-related psychiatric disorders. In this...
Beck, Daniel Ben Maamar, Millissia Skinner, Michael K.
Published in
Epigenetics & Chromatin
BackgroundEnvironmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheritance is mediated through epigenetic alterations in the sperm and/or egg to subsequent generations. Although the combined regulatio...
Si, Yufeng He, Feng Wen, Haishen Li, Siping He, Huiwen
Published in
Journal of Ocean University of China
Pituitary adenylate cyclase activating polypeptide (PACAP) and growth hormone-releasing hormone (GHRH) play important roles in the GH/IGF growth axis in fishes. To determine whether epigenetic change is involved in the regulation of pacap and ghrh responses to low salinity stress in Cynoglossus semilaevis, the correlation between growth traits, DNA...
Wang, Xinyan Li, Zhenshu Zhu, Yun Yan, Jing Liu, Huan Huang, Guowei Li, Wen
Published in
Genes & Nutrition
BackgroundPericonceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive performances in offspring. However, the genes or pathways that are epigenetically regulated by FA in neurodevelopment were rarely reported.MethodsTo elucidate the underlying mechanism, the effect of FA on the...
Shao, Dongyan Ye, Linjie Zhu, Bobo Li, Qi Yang, Hui Shi, Junling Huang, Qingsheng Zhao, Wen
Published in
Microgravity Science and Technology
The inhibition of the cytotoxicity of NK cells by microgravity in space is of serious concern to the health of astronauts. However, there remains a lack of in-depth research into the mechanisms of action of this suppression. In the present study, the effects of simulated microgravity (SMG) on the morphology, survival rate and the ability of NK cell...
Liu, Xuanyi Liu, Xiaozhou Shi, Qiaoyu Fan, Xiuqin Qi, Kemin
Published in
BMC Pediatrics
BackgroundTelomeres play a crucial role in cellular survival and its length is a predictor for onset of chronic non-communicable diseases. Studies on association between telomeres and obesity in children have brought discrepant results and the underlying mechanisms and influential factors are to be elucidated. This study aimed to investigate change...
Lindner, Melanie Verhagen, Irene Viitaniemi, Heidi M. Laine, Veronika N. Visser, Marcel E. Husby, Arild van Oers, Kees
Published in
BMC Genomics
BackgroundDNA methylation is likely a key mechanism regulating changes in gene transcription in traits that show temporal fluctuations in response to environmental conditions. To understand the transcriptional role of DNA methylation we need simultaneous within-individual assessment of methylation changes and gene expression changes over time. With...
Yuan, Victor Hui, Desmond Yin, Yifan Peñaherrera, Maria S. Beristain, Alexander G. Robinson, Wendy P.
Published in
BMC Genomics
BackgroundDNA methylation (DNAm) profiling has emerged as a powerful tool for characterizing the placental methylome. However, previous studies have focused primarily on whole placental tissue, which is a mixture of epigenetically distinct cell populations. Here, we present the first methylome-wide analysis of first trimester (n = 9) and term (n = ...
