dos santos, kelly karoline daniel, isabelle watanabe delabio, letícia carani da costa, manoella abrão dutra, júlia de paula ruginsk, bruna estelita nardin, jeanine marie campos, louryana padilha de moraes rego, fabiane gomes picheth, geraldo
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One of the major challenges of studying biomarkers in tumor samples is the low quantity and quality of isolated RNA, DNA, and proteins. Additionally, the extraction methods ideally should obtain macromolecules from the same tumor biopsy, allowing better-integrated data interpretation. In this work, an in-house, low-cost, mixed-type tissue crusher c...
Sufiyan, Nudrat Sharma, Anup Kumar
Published in
Semiconductor Science and Technology
In this work, AlGaN/AlN/GaN MOS-HEMTs were investigated with a biomolecule cavity between two oxide layers under the gate region to determine their sensitivity and viability as biosensors. The area between the two oxide layers located below the gate electrode was used to detect the SARS-CoV-2 virus through DNA proteins. Threshold voltage and drain ...
bourgès, anaïs c. garre, massimiliano dan, wu o’shea, donal f.
The endoplasmic reticulum and the internal nuclear compartments are intrinsically connected through the nuclear membrane, pores and lamina. High resolution imaging of each of these cellular features concurrently remains a significant challenge. To that end we have developed a new molecular nuclear membrane-endoplasmic reticulum (NM-ER) staining flu...
Zhao, Lei Henriksen, Rasmus Ramsøe, Abigail Nielsen, Rasmus Korneliussen, Thorfinn
One essential initial step in the analysis of ancient DNA is to authenticate that the DNA sequencing reads are actually from ancient DNA. This is done by assessing if the reads exhibit typical characteristics of post-mortem damage (PMD), including cytosine deamination and nicks. We present a novel statistical method implemented in a fast multithrea...
Lundin, Jessica I Peters, Ulrike Hu, Yao Ammous, Farah Avery, Christy L Benjamin, Emelia J Bis, Joshua C Brody, Jennifer A Carlson, Chris Cushman, Mary
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Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation is an epigenetic modification in the DNA which plays a pivotal role in gene expression. In th...
klabenkova, kristina zakhryamina, alyona burakova, ekaterina bizyaev, sergei fokina, alesya stetsenko, dmitry
Nowadays, nucleic acid derivatives capable of modulating gene expression at the RNA level have gained widespread recognition as promising therapeutic agents. A suitable degree of biological stability of oligonucleotide therapeutics is required for in vivo application; this can be most expeditiously achieved by the chemical modification of the inter...
chatgilialoglu, chryssostomos peluso, andrea
In this review, we focus on the one-electron oxidation of DNA, which is a multipart event controlled by several competing factors. We will discuss the oxidation free energies of the four nucleobases and the electron detachment from DNA, influenced by specific interactions like hydrogen bonding and stacking interactions with neighboring sites in the...
sbirkova-dimitrova, hristina rusew, rusi gerginov, hristo heroux, annie shivachev, boris l.
Recently, there have been numerous reports on the use of different fluorescent DNA stains for specific minor groove binding. The exploration of biological markers increases the safety of their use as diagnostic criteria. Single crystal analysis of DNA–ligand binding interactions is of essential importance to obtain the requirements for their usage ...
allysson, francisco pereira cavalcanti, raquel fragoso duvirgens vieira, cosmo isaias de oliveira, joao batista de lima, louíse mangueira alves, adriano francisco bezerra pessoa, matheus marley batista, leônia maria dejani, naiara naiana piuvezam, marcia regina
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Background/Objectives: Acute lung injury (ALI) is an inflammatory disorder affecting patients in intensive care with high mortality. No specific pharmacological treatment is available. Musa paradisiaca L. (banana) is a cosmopolitan plant, and homemade syrup from its inflorescence is used in many countries to treat pulmonary inflammation. Therefore,...
Suspène, Rodolphe Guardado-Calvo, Pablo Dairou, Julien Bonhomme, Frédéric Bonenfant, Christine Guyetant, Serge Lecomte, Thierry Pagès, Jean-Christophe Vartanian, Jean-Pierre
Perturbation of the deoxyribonucleotide triphosphate (dNTP) pool is recognized for contributing to the mutagenic processes involved in oncogenesis. The RAS gene family encodes well characterized oncoproteins whose structure and function are among the most frequently altered in several cancers. In this work, we show that fluctuation of the dNTP pool...
