Timmermans, Steven Verhoog, Nicolette J D Van Looveren, Kelly Dewaele, Sylviane Hochepied, Tino Eggermont, Melanie Gilbert, Barbara Boerema-de Munck, Anne Vanderhaeghen, Tineke Vanden Berghe, Joke
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Published in
The Journal of biological chemistry
The glucocorticoid (GC) receptor (GR) is essential for normal development and in the initiation of inflammation. Healthy GRdim/dim mice with reduced dimerization propensity due to a point mutation (A465T) at the dimer interface of the GR DNA-binding domain (DBD) (here GRD/D) have previously helped to define the functions of GR monomers and dimers. ...
Liu, Tengyuan; 100891; Zhang, Tingting; Nicolas, Maya; Boussicault, Lydie; Rice, Heather; Soldano, Alessia; Claeys, Annelies; 24512; Petrova, Iveta; Fradkin, Lee; De Strooper, Bart; 12249;
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The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be. We show that APP binds the Wnt ligands Wnt3a and Wnt5a and that thi...
Chen, Jian Wang, Hongyan Deng, Lili Wang, Hui Li, Zengxi
Butene oligomerization followed by hydrogenation is regarded as a promising way to produce alkylate oil, and the challenge of this process is the oriented conversion of butene to octene, which closely relates to the alkylate quality. Ionic liquids (ILs) are a kind of promising catalyst for olefin oligomerization. In this study, a series of function...
Chen, Jian Wang, Hongyan Deng, Lili Wang, Hui Li, Zengxi
Butene oligomerization followed by hydrogenation is regarded as a promising way to produce alkylate oil, and the challenge of this process is the oriented conversion of butene to octene, which closely relates to the alkylate quality. Ionic liquids (ILs) are a kind of promising catalyst for olefin oligomerization. In this study, a series of function...
Lucey, M Ashik, T Marzook, A Wang, Y Goulding, J Oishi, A Broichhagen, J Hodson, D Minnion, J Elani, Y
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The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affects sustained glucose-stimulated insulin secretion through avoidance of desensitisation and downregulation. A num...
Brancart, Joost Van Damme, Jonas Du Prez, Filip Van Assche, Guy
The chemical structure and location of substituents on anthracene derivatives influence the electron balance of the aromatic system, thus determining the wavelengths at which light is absorbed, which results in the photochemically induced dimerization or monomerization. Here, the thermal dissociation kinetics of 7 photodimers of 9-substituted anthr...
Dumoleijn, Kim Van Den Broeck, Elias Stavinoha, J. Van Speybroeck, Veronique Moonen, K. Stevens, Christian
The first heterogeneously catalyzed process for the reductive coupling of imines and iminium ions is reported using precious metal catalysts in combination with hydrogen gas as the terminal reductant. The optimized method in terms of catalyst composition and reaction conditions allowed to produce aro-matic vicinal diamines without the use of stoich...
Ferraiolo, Mattia Atik, Hicham Ponthot, Romane Nascimento, Ines Belo do Beckers, Pauline Stove, Christophe Hermans, Emmanuel
Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we hypothesized that receptor density might influence constitutive and ligand-induced homodimerization. Using a nanoluciferase-based complementation assay to monitor dopa -mine D2L receptor homodimeriza...
Telford, Marco Hughes, David A Juan, David Stoneking, Mark Navarro, Arcadi Santpere, Gabriel
Published in
Microorganisms
The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation in incidence among global geographical regions. Genetic variants in EBV genomic sequences have been used to determine the geograph...
Leppanen, Veli-Matti; Brouillard, Pascal; Korhonen, Emilia A; Sipila, Tuomas; Jha, Sawan Kumar; Revencu, Nicole; Labarque, Veerle; 41869; Fastre, Elodie; Schlogel, Matthieu; Ravoet, Marie;
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Primary lymphedema is caused by developmental and functional defects of the lymphatic vascular system that result in accumulation of protein-rich fluid in tissues, resulting in edema. The 28 currently known genes causing primary lymphedema can explain
