Rapamycin (or sirolimus) is a macrolide that has shown to be useful as an immunosuppressant and that was studied in metabolic, neurological, or genetic disorders. Rapamycin is a specific natural inhibitor of the mechanistic target of rapamycin (mTOR) that is a kinase protein playing a pivotal role in cell growth and proliferation by activation of s...
Causal reasoning can shed new light on the major challenges in ma-chine learning for medical imaging: scarcity of high-quality annotated data and mismatch between the development dataset and the target environment. A causal perspective on these issues allows decisions about data collection, annotation, preprocessing, and learning strategies to be m...
Phase transition in quantum many-body systems inevitably causes changes in certain physical properties which then serve as potential indicators of critical phenomena. Besides the traditional order parameters, characterization of quantum entanglement has proven to be a computationally efficient and successful method for detection of phase boundaries...
We report a discovery of shocked gas from the supernova remnant (SNR) G357.7+0.3. Our millimeter and submillimeter observations reveal broad molecular lines of CO(2-1), CO(3-2), CO(4-3), 13CO (2-1), and 13CO (3-2), HCO+, and HCN using the Heinrich Hertz Submillimeter Telescope, the Arizona 12 m Telescope, APEX, and the MOPRA Telescope. The widths o...
Regional frequency analysis based on L-moments was applied to assess the spatial extent of meteorological droughts in tandem with their return periods in Zambia. Weather station monthly rainfall data were screened to form homogeneous sub-regions-, validated by a homogeneity criterion and fitted by a generalized extreme value distribution using good...
Published in Information Systems and e-Business Management
The construction of business process models has become an important requisite in the analysis and optimization of processes. The success of the analysis and optimization efforts heavily depends on the quality of the models. Therefore, a research domain emerged that studies the process of process modeling. This paper contributes to this research by ...
Published in European Journal of Epidemiology
The current deconstruction of paradoxes is one among several signs that a profound renewal of methods for clinical and epidemiological research is taking place; perhaps for some basic life sciences as well. The new methodological approaches have already deconstructed and explained long puzzling apparent paradoxes, including the (non-existent) benef...
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In this paper we present a semiparametric test of goodness of fit which is based on the method of L-moments for the estimation of the nuisance parameters. This test is particularly useful for any distribution that has a convenient expression for its quantile function. The test proceeds by investigating equality of the first few L-moments of the tru...
