Infective endocarditis in patients after percutaneous pulmonary valve implantation with the stent-mounted bovine jugular...
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Features and outcome of chronic myeloid leukemia at very young age: Data from the International Pediatric Chronic Myeloi...
Introduction Chronic myeloid leukemia (CML) is rare in the first two decades of life comprising only 3% of newly diagnosed pediatric and adolescent leukemias. We studied the epidemiologic and clinical features of patients with CML diagnosed at younger than 3 years of age and evaluated treatment and long-term outcome. Method Data from the Internatio...
A BBS1 SVA F retrotransposon insertion is a frequent cause of Bardet-Biedl syndrome
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Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinitis pigmentosa, obesity, polydactyly, cognitive impairment and renal failure. Pathogenic variants in 24 genes account for the molecular basis of >80% of cases. Toward saturated discovery of the mutational basis of the disorder, we carefully explored our cohorts and identified a homi...
Reactive attachment disorder symptoms and prosocial behavior in middle childhood: the role of Secure Base Script knowled...
BACKGROUND: Children with attachment disorder show prosocial behavior problems. Children with a reactive attachment disorder show inhibited and emotionally withdrawn behavior. Consequently, these children typically display prosocial behavior problems. However, the underlying mechanism between reactive attachment disorder and prosocial behavior prob...
One-year efficacy and safety of ravulizumab in adults with paroxysmal nocturnal hemoglobinuria naive to complement inhib...
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Background: Ravulizumab, the only long-acting complement C5 inhibitor for adults with paroxysmal nocturnal hemoglobinuria (PNH), demonstrated non-inferiority to eculizumab after 26 weeks of treatment in complement inhibitor-naïve patients during a phase III randomized controlled trial. We present open-label extension results with up to 52 weeks of ...
Community-acquired bacterial meningitis in adults: emergency department management protocol
Acute bacterial meningitis (ABM) is a rare but disabling infectious condition that requires a performant multidisciplinary management approach. Between 70 and 90 adult patients are diagnosed with community-acquired ABM in Belgium annually, and reported case fatality rates range from 17 to 40%. The currently available guidelines provide evidence-bas...
A retrospective long-term pulpal, periodontal, and esthetic, follow-up of palatally impacted canines treated with an ope...
INTRODUCTION: The primary objective of this study was to compare the aesthetic outcome of palatally impacted canines treated with an open or closed surgical exposure technique using the Maxillary Canine Aesthetic Index (MCAI) at least 1 year after debonding. Secondary objectives were set on the periodontal outcome, tooth color, pulpal status, and s...
Clinical management, ethics and informed consent related to multi-gene panel-based high throughput sequencing testing fo...
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Molecular diagnostics of inherited platelet disorders (IPD) has been revolutionized by the implementation of high-throughput sequencing (HTS) approaches. A conclusive diagnosis using HTS tests can be obtained quickly and cost-effectively in many, but not all patients. The expanding use of HTS tests has raised concerns regarding complex variant inte...
Angiosarcoma in an arteriovenous fistula after kidney transplantation: Case report and review of treatment options.
Published in Hemodialysis international. International Symposium on Home Hemodialysis
We present a patient with an angiosarcoma in an arteriovenous fistula and we reviewed current treatments for angiosarcomas. We extended the systematic review by Oskrochi et al. on this topic in 2015, using the same search query. We searched systematically OVID, EMBASE and PubMed from April 2015 until January 2020 with the aim to update the state of...
Impact of an extended audit on identifying heart failure patients in general practice: baseline results of the OSCAR-HF ...
AIMS: Identifying heart failure (HF) patients in general practice is challenging, and little is known about the current quality of care. We implemented an extended audit from the electronic health records (EHRs) of general practitioners (GPs) to identify HF patients and investigate patient characteristics and quality of care. METHODS AND RESULTS: T...
