Wichmann, Anne B. Adang, Eddy M. M. Vissers, Kris C. P. Szczerbińska, Katarzyna Kylänen, Marika Payne, Sheila Gambassi, Giovanni Onwuteaka-Philipsen, Bregje D. Smets, Tinne Van den Block, Lieve
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Published in
BMC Medicine
BackgroundThe number of residents in long-term care facilities (LTCFs) in need of palliative care is growing in the Western world. Therefore, it is foreseen that significantly higher percentages of budgets will be spent on palliative care. However, cost-effectiveness analyses of palliative care interventions in these settings are lacking. Therefore...
Ebrahimpur, Mahbube Sharifi, Farshad Shadman, Zhaleh Payab, Moloud Mehraban, Saghar Shafiee, Gita Heshmat, Ramin Fahimfar, Noushin Mehrdad, Neda Khashayar, Patricia
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Published in
Archives of Osteoporosis
SummaryCognitive impairment and osteoporosis are frequently seen to coincide in clinical practice. Osteoporosis was higher in elderly populations with cognitive impairment, especially in postmenopausal women. Thus, prophylaxis for osteoporosis, falls, and fractures should be considered as part of the treatment of patients with cognitive impairment....
Ford, J Zheng, B Hurtado, B De Jager, CA Udeh-Momoh, C Middleton, L Price, G
Alzheimer's disease (AD) is the most common form of dementia, impacting global cognitive performance, including episodic memory. Semantic clustering is a learning strategy involving grouping words of similar meaning and can improve episodic memory performance, e.g., list learning. As the APOE ε4 allele is the most validated genetic risk factor for ...
Delva, Aline; 123327; Van Weehaeghe, Donatienne; 110770; Koole, Michel; 54596; Van Laere, Koen; 40740; Vandenberghe, Wim; 5312;
BACKGROUND: It has been hypothesized that the pathology of Parkinson's disease (PD) primarily affects presynaptic terminals and spreads trans-synaptically. OBJECTIVES: The main objective of this study was to assess the magnitude and anatomical extent of presynaptic terminal loss across the brain in early PD. A second objective was to compare loss o...
Popescu, SG Whittington, A Gunn, RN Matthews, PM Glocker, B Sharp, DJ Cole, JH
Multiple biomarkers can capture different facets of Alzheimer's disease. However, statistical models of biomarkers to predict outcomes in Alzheimer's rarely model nonlinear interactions between these measures. Here, we used Gaussian Processes to address this, modelling nonlinear interactions to predict progression from mild cognitive impairment (MC...
Hadjichrysanthou, C Evans, S Bajaj, S Siakallis, LC McRae-McKee, K De Wolf, F Anderson, RM
Background Quantifying changes in the levels of biological and cognitive markers prior to the clinical presentation of Alzheimer’s disease (AD) will provide a template for understanding the underlying aetiology of the clinical syndrome and, concomitantly, for improving early diagnosis, clinical trial recruitment and treatment assessment. This study...
Tome, Sandra O; Vandenberghe, Rik; 5277; Ospitalieri, Simona; Van Schoor, Evelien; 118823; Tousseyn, Thomas; 42009; Otto, Markus; von Arnim, Christine AF; Thal, Dietmar Rudolf; 97737;
The co-existence of multiple pathologies and proteins is a common feature in the brains of cognitively impaired elderly individuals. Transactive response DNA-binding protein (TDP-43) has been discovered to accumulate in limbic brain regions of a portion of late-onset Alzheimer's disease (AD) patients, in addition to amyloid-β and τ protein. However...
Collingridge Moore, Danni Payne, Sheila Keegan, Thomas Deliens, Luc Smets, Tinne Gambassi, Giovanni Kylänen, Marika Kijowska, Violetta Onwuteaka-Philipsen, Bregje Van den Block, Lieve
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Published in
International Journal of Environmental Research and Public Health
Long term care facilities (LTCFs) are increasingly a place of care at end of life in Europe. Longer residence in an LTCF prior to death has been associated with higher indicators of end of life care; however, the relationship has not been fully explored. The purpose of this analysis is to explore associations between length of stay and end of life ...
Lueningschror, Patrick; Wemer, Georg; Stroobants, Stijn; Kakuta, Soichiro; Dombert, Benjamin; Sinske, Daniela; Wanner, Renate; Luellmann-Rauch, Renate; Wefers, Benedikt; Wurst, Wolfgang;
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Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiological function of TMEM106B, we generated TMEM106B-deficient mice. These mice develop proximal axonal swellin...
Barańska, Ilona Kijowska, Violetta Engels, Yvonne Finne-Soveri, Harriet Froggatt, Katherine Gambassi, Giovanni Hammar, Teija Oosterveld-Vlug, Mariska Payne, Sheila Van Den Noortgate, Nele
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Published in
Journal of the American Medical Directors Association
To examine how relatives evaluate the quality of communication with the treating physician of a dying resident in long-term care facilities (LTCFs) and to assess its differences between countries. A cross-sectional retrospective study in a representative sample of LTCFs conducted in 2015. Relatives of residents who died during the previous 3 months...
