Khoma, Vira Martinyuk, Viktoria Matskiv, Tetyana Gnatyshyna, Lesya Baranovsky, Vitaliy Gladiuk, Mykola Gylytė, Brigita Manusadžianas, Levonas Stoliar, Oksana
Published in
Environmental Science and Pollution Research International
Bivalve molluscs represent the most recognized bioindicators of freshwater pollution. However, their ability to indicate specific xenobiotics in complex exposures is unclear. In this study, we aimed to track the particular effects of the pesticide Roundup (Rnd) and the antipsychotic drug chlorpromazine (Cpz) on the mussel Unio tumidus at the simple...
Johari, Seyed Ali Sarkheil, Mehrdad Veisi, Shakila
Published in
Environmental science and pollution research international
Zinc (zeolitic) imidazolate framework 8 (ZIF-8) has been widely considered in the literature as an ideal candidate for drug delivery especially anti-cancer drugs. However, the available information on the biocompatibility and cytotoxicity of ZIF-8 nanoparticles is contradictory. Therefore, in the present study, the ZIF-8 particles were synthetized,...
Bitchagno, Gabin Thierry M Schüffler, Anja Simo, Ingrid K Krumb, Matthias Tane, Pierre Opatz, Till
Published in
Natural product research
Two hitherto unknown neo-clerodane-type diterpenoids along with twelve known compounds have been isolated from Conyza pyrrhopappa Sch.Bip. ex A.Rich, a medicinal plant traditionally used across tropical Africa to relieve fever. The structures of isolates have been elucidated by a combination of spectroscopic techniques. The crude extract and the is...
Ncube, Sibonokuhle F. McGaw, Lyndy J. Njoya, Emmanuel Mfotie Ndagurwa, Hilton G. T. Mundy, Peter J. Sibanda, Samson
Published in
BMC Complementary Medicine and Therapies
Background This study evaluated the in vitro antioxidant activity and comparison of anti-inflammatory and cytotoxic activity of Harpagopytum zeyheri with diclofenac. Methods In vitro assays were conducted using water, ethanol, and ethyl acetate extracts of H.zeyheri . The antioxidant activity was evaluated using the 2,2′-diphenyl-1-picrylhydrazy (D...
Amaya, Celina Luo, Shihua Baigorri, Julio Baucells, Rogelio Smith, Elizabeth R. Xu, Xiang-Xi
Published in
BMC Cancer
Background Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemotherapy using paclitaxel in combination with carboplatin as a frontline agent, and paclitaxel is also used in salvage treatment as...
Gordeeva, Olga Safandeev, Vitaliy
Published in
Neuropharmacology
Biogenic monoamines are involved in the regulation of various processes in both neural and non-neural cells during development. The present study aimed to identify the regulatory effects of serotonin (5-HT) and its precursors (l-tryptophan and 5-hydroxytryptophan, 5-HTP) on proliferation and cell death in mouse embryonic stem cells (ESCs) and embry...
Jabłońska-Trypuć, Agata Wydro, Urszula Wołejko, Elżbieta Pietryczuk, Anna Cudowski, Adam Leszczyński, Jacek Rodziewicz, Joanna Janczukowicz, Wojciech Butarewicz, Andrzej
Published in
Environmental geochemistry and health
Leachate from landfills is a product of complex biological and physicochemical processes occurring during waste storage. In the present study, the toxicity of landfill leachate (LL) to human and bacterial cells was investigated for better understanding of LL environmental toxicity. Studies regarding LL physicochemical properties and cytotoxicity an...
Kaennakam, Sutin Sukandar, Edwin Risky Juntagoot, Thanawan Siripong, Pongpun Tip-Pyang, Santi
Published in
Journal of natural medicines
Four new xanthones, named schomburgones C-F (1‒4), along with six known xanthones (5‒10) were isolated from the stems of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines. Furan...
Celik, Neslihan Binnetoglu, Damla Ozakar Ilday, Nurcan Hacimuftuoglu, Ahmet Seven, Nilgun
Published in
Drug and chemical toxicology
The aim of this study was to evaluate the cytotoxic and oxidative effects of the most commonly used dental restorative materials on human gingival fibroblast cells (HGFCs). HGFCs were obtained from healthy individuals. The tested restorative materials were a microhybrid resin based composite, a compomer resin, a glass ionomer cement, and an amalgam...
Agha, Amani Parker, Sandra Parkinson, Eric Kenneth Patel, Mangala
Published in
Dental materials : official publication of the Academy of Dental Materials
Resin-modified glass ionomer cements (RMGICs) present several advantages (e.g. fluoride release), but their reported cytotoxicity has been associated with hydroxyethyl methacrylate (HEMA) monomer release. Therefore, different monomers were tested for use in RMGICs in order to improve their biocompatibility and reduce monomer release. Eight experime...
